Wael M Samy1, Asser I Ghoneim, Nazik A Elgindy. 1. Alexandria University, Department of Industrial Pharmacy, Faculty of Pharmacy , Alexandria , Egypt +2 03 3630 815 ; +2 03 4873 273 ; wsamy73@yahoo.com , w.sami@bau.edu.lb.
Abstract
PURPOSE: Study the possible benefit of combining biodegradable polymers with sildenafil citrate (SC) in wound healing. METHOD: Biodegradable micronized powdered formulations of SC were prepared by spray drying using chitosan (P₁) or chitosan/gum Arabic (P₂). Powders were characterized by differential scanning calorimetry, Scanning electron microscope, particle size analysis, flow and swelling behavior. The powders were also incorporated into microstructured gels and in vitro SC release from powders and gels was tested. In vivo wound healing acceleration was tested by measuring area contraction of excision wounds and histologically. Post-healing tensile strength (TS) for incision wounds in rats receiving powder formulations was tested. RESULTS: The powders were in the micron-size range showing no SC-polymers interaction. Powders had poor flow with angle of repose (θ) of 41 - 48°, and high moisture uptake reaching 107% for placebo powder P₁. Good excision wound healing was seen with P1 and G1 formulations showing 98.4 and 98.5% reduction in wound area, respectively, compared with 83% for the control. Incision wounds were improved with P1 showing TS value of 6.9 compared with 3.7 kg/cm² for control. Histological examinations supported. CONCLUSION: Spray-dried chitosan/SC powder (P₁) and its gel form (G₁) could be promising wound healing promoters as supported by the histological examinations.
PURPOSE: Study the possible benefit of combining biodegradable polymers with sildenafil citrate (SC) in wound healing. METHOD: Biodegradable micronized powdered formulations of SC were prepared by spray drying using chitosan (P₁) or chitosan/gum Arabic (P₂). Powders were characterized by differential scanning calorimetry, Scanning electron microscope, particle size analysis, flow and swelling behavior. The powders were also incorporated into microstructured gels and in vitro SC release from powders and gels was tested. In vivo wound healing acceleration was tested by measuring area contraction of excision wounds and histologically. Post-healing tensile strength (TS) for incision wounds in rats receiving powder formulations was tested. RESULTS: The powders were in the micron-size range showing no SC-polymers interaction. Powders had poor flow with angle of repose (θ) of 41 - 48°, and high moisture uptake reaching 107% for placebo powder P₁. Good excision wound healing was seen with P1 and G1 formulations showing 98.4 and 98.5% reduction in wound area, respectively, compared with 83% for the control. Incision wounds were improved with P1 showing TS value of 6.9 compared with 3.7 kg/cm² for control. Histological examinations supported. CONCLUSION: Spray-dried chitosan/SC powder (P₁) and its gel form (G₁) could be promising wound healing promoters as supported by the histological examinations.
Authors: Mohamed A Ashour; Waseem Fatima; Mohd Imran; Mohammed M Ghoneim; Sultan Alshehri; Faiyaz Shakeel Journal: Molecules Date: 2022-02-09 Impact factor: 4.411
Authors: Sarah A El-Lakany; Ahmed I Abd-Elhamid; Elbadawy A Kamoun; Esmail M El-Fakharany; Wael M Samy; Nazik A Elgindy Journal: Int J Nanomedicine Date: 2019-10-16