S R Kholoud1, M K A Iman2, E H Rasha3, S S A Soha3. 1. Department of Biochemistry, Faculty of Girls Science, King Abdulaziz University, Jeddah, Saudi Arabia ; Biochemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt. 2. Department of hydrobiology, National Research Center, Cairo, Egypt. 3. Biochemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.
Abstract
BACKGROUND: Myocarditis is an uncommon disease that presents with a wide range of symptoms in children and adults. It is histologically characterized by varying degrees of myocardialnecrosis, edema and cellular infiltration myocardial inflammation is a nonspecificresponse to many triggers such as bacterial infection, cardio toxic agents, ormechanical injury. OBJECTIVE: This study was carried out to investigate the experimental Streptococcus faecalis induction of myocarditis and its effect on some blood parameters, inflammatory markers and histopathological changes in male albino rats. METHODS: Rats were infected by intraperitoneal injection of 10 8 CFU/ml of Streptococcus faecalis and sacrificed after one, two and seven days post infection. Biochemical analyses of blood were carried out to investigate the serum biomarkers of inflammation, liver function tests, cardiac enzymes & kidney function tests. RESULTS: All biochemical analyses showed statistically significant increase in the measured parameters due to bacterial infections except for blood urea which appear to be normal. A significant positive correlation was observed between lactate dehydrogenase enzyme (LDH) with creatinine (r =0.778, P<0.01). In the 7 days group, there were significant positive correlations between aspartate aminotransferase (AST) and alanine aminotransferase (ALT) (r=0.675, P<0.05), erythrocyte sedimentation rate (ESR) with Urea (r=0.659, P<0.05) and alkaline phosphatase (ALP) with C-reactive protein (CRP) (r=0.765, p<0.01). CONCLUSION: Many of these biomarkers will provide important new insights into pathophysiology and aid in the diagnosis and management of cardiovascular patients.
BACKGROUND:Myocarditis is an uncommon disease that presents with a wide range of symptoms in children and adults. It is histologically characterized by varying degrees of myocardialnecrosis, edema and cellular infiltration myocardial inflammation is a nonspecificresponse to many triggers such as bacterial infection, cardio toxic agents, ormechanical injury. OBJECTIVE: This study was carried out to investigate the experimental Streptococcus faecalis induction of myocarditis and its effect on some blood parameters, inflammatory markers and histopathological changes in male albino rats. METHODS:Rats were infected by intraperitoneal injection of 10 8 CFU/ml of Streptococcus faecalis and sacrificed after one, two and seven days post infection. Biochemical analyses of blood were carried out to investigate the serum biomarkers of inflammation, liver function tests, cardiac enzymes & kidney function tests. RESULTS: All biochemical analyses showed statistically significant increase in the measured parameters due to bacterial infections except for blood urea which appear to be normal. A significant positive correlation was observed between lactate dehydrogenase enzyme (LDH) with creatinine (r =0.778, P<0.01). In the 7 days group, there were significant positive correlations between aspartate aminotransferase (AST) and alanine aminotransferase (ALT) (r=0.675, P<0.05), erythrocyte sedimentation rate (ESR) with Urea (r=0.659, P<0.05) and alkaline phosphatase (ALP) with C-reactive protein (CRP) (r=0.765, p<0.01). CONCLUSION: Many of these biomarkers will provide important new insights into pathophysiology and aid in the diagnosis and management of cardiovascularpatients.
Authors: Nguyen Hoan Phu; Tran Tinh Hien; Nguyen Thi Hoang Mai; Tran Thi Hong Chau; Ly Van Chuong; Pham Phu Loc; Christopher Winearls; Jeremy Farrar; Nicholas White; Nicholas Day Journal: N Engl J Med Date: 2002-09-19 Impact factor: 91.245
Authors: Michael G Shlipak; Paul A Heidenreich; Haruko Noguchi; Glenn M Chertow; Warren S Browner; Mark B McClellan Journal: Ann Intern Med Date: 2002-10-01 Impact factor: 25.391