4-Phenyl-1,2,4-tri-aza-spiro-[4.6]undec-1-ene-3-thione.

In the title compound, C14H17N3S, the plane of the phenyl ring makes a dihedral angle of 74.90 (4)° with that of the tri-aza-thione ring (r.m.s. deviation = 0.001 Å), while the seven-membered ring adopts a twist-chair conformation. No specific intermolecular interactions are discerned in the crystal packing.

Related literature

For various pharmaceutical properties of spiro compounds, see: Chin et al. (2008 ▶); Thadhaney et al. (2010 ▶). For industrial uses of heterocyclic spiro compounds, see: Sarma et al. (2010 ▶). For the crystal structures of two similar compounds, see: Akkurt et al. (2013 ▶); Mague et al. (2014 ▶). For ring-puckering parameters, see: Cremer & Pople (1975 ▶).

Experimental

Crystal data

C14H17N3S

M = 259.36

Triclinic,

a = 9.0578 (5) Å

b = 9.1324 (5) Å

c = 9.4637 (5) Å

α = 88.2940 (8)°

β = 79.0690 (7)°

γ = 61.6640 (6)°

V = 674.89 (6) Å3

Z = 2

Mo Kα radiation

μ = 0.23 mm−1

T = 150 K

0.28 × 0.23 × 0.06 mm

Data collection

Bruker SMART APEX CCD diffractometer

Absorption correction: multi-scan (SADABS; Bruker, 2013 ▶) T min = 0.85, T max = 0.98

12510 measured reflections

3508 independent reflections

3125 reflections with I > 2σ(I)

R int = 0.032

Refinement

R[F 2 > 2σ(F 2)] = 0.036

wR(F 2) = 0.096

S = 1.04

3508 reflections

163 parameters

H-atom parameters constrained

Δρmax = 0.44 e Å−3

Δρmin = −0.20 e Å−3

Data collection: APEX2 (Bruker, 2013 ▶); cell refinement: SAINT (Bruker, 2013 ▶); data reduction: SAINT; program(s) used to solve structure: SHELXT (Bruker, 2013 ▶); program(s) used to refine structure: SHELXL2014 (Sheldrick, 2008 ▶); molecular graphics: DIAMOND (Brandenburg & Putz, 2012 ▶); software used to prepare material for publication: SHELXTL (Sheldrick, 2008 ▶).

Crystal structure: contains datablock(s) global, I. DOI: 10.1107/S1600536814009817/hg5394sup1.cif

Structure factors: contains datablock(s) I. DOI: 10.1107/S1600536814009817/hg5394Isup2.hkl

Click here for additional data file.

Supporting information file. DOI: 10.1107/S1600536814009817/hg5394Isup3.cml

CCDC reference: 1000439

Additional supporting information: crystallographic information; 3D view; checkCIF report

C14H17N3S	Z = 2
Mr = 259.36	F(000) = 276
Triclinic, P1	Dx = 1.276 Mg m−3
Hall symbol: -P 1	Mo Kα radiation, λ = 0.71073 Å
a = 9.0578 (5) Å	Cell parameters from 9063 reflections
b = 9.1324 (5) Å	θ = 2.2–29.1°
c = 9.4637 (5) Å	µ = 0.23 mm−1
α = 88.2940 (8)°	T = 150 K
β = 79.0690 (7)°	Plate, orange
γ = 61.6640 (6)°	0.28 × 0.23 × 0.06 mm
V = 674.89 (6) Å3

Bruker SMART APEX CCD diffractometer	3508 independent reflections
Radiation source: fine-focus sealed tube	3125 reflections with I > 2σ(I)
Graphite monochromator	Rint = 0.032
Detector resolution: 8.3660 pixels mm-1	θmax = 29.1°, θmin = 2.2°
φ and ω scans	h = −12→12
Absorption correction: multi-scan (SADABS; Bruker, 2013)	k = −12→12
Tmin = 0.85, Tmax = 0.98	l = −12→12
12510 measured reflections

Refinement on F2	Primary atom site location: structure-invariant direct methods
Least-squares matrix: full	Secondary atom site location: difference Fourier map
R[F2 > 2σ(F2)] = 0.036	Hydrogen site location: inferred from neighbouring sites
wR(F2) = 0.096	H-atom parameters constrained
S = 1.04	w = 1/[σ2(Fo2) + (0.0469P)2 + 0.2315P] where P = (Fo2 + 2Fc2)/3
3508 reflections	(Δ/σ)max < 0.001
163 parameters	Δρmax = 0.44 e Å−3
0 restraints	Δρmin = −0.20 e Å−3

Geometry. Bond distances, angles etc. have been calculated using the rounded fractional coordinates. All su's are estimated from the variances of the (full) variance-covariance matrix. The cell e.s.d.'s are taken into account in the estimation of distances, angles and torsion angles

Refinement. Refinement on F2 for ALL reflections except those flagged by the user for potential systematic errors. Weighted R-factors wR and all goodnesses of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The observed criterion of F2 > σ(F2) is used only for calculating -R-factor-obs etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R-factors based on ALL data will be even larger.

	x	y	z	Uiso*/Ueq
S1	1.18135 (4)	0.44697 (4)	0.80140 (3)	0.0246 (1)
N1	0.85249 (12)	0.58855 (11)	0.76728 (10)	0.0161 (2)
N2	0.75975 (13)	0.84504 (12)	0.87544 (11)	0.0222 (3)
N3	0.91495 (13)	0.75963 (13)	0.87953 (11)	0.0223 (3)
C1	0.98219 (14)	0.59098 (14)	0.81285 (12)	0.0180 (3)
C2	0.69598 (14)	0.75078 (13)	0.80402 (12)	0.0169 (3)
C3	0.85298 (13)	0.44117 (13)	0.71782 (12)	0.0165 (3)
C4	0.85413 (15)	0.32566 (14)	0.81669 (13)	0.0205 (3)
C5	0.84438 (16)	0.18734 (15)	0.77211 (14)	0.0255 (3)
C6	0.83537 (18)	0.16576 (16)	0.63011 (15)	0.0292 (4)
C7	0.83794 (18)	0.28004 (17)	0.53131 (14)	0.0294 (4)
C8	0.84735 (15)	0.41916 (15)	0.57489 (12)	0.0219 (3)
C9	0.55281 (15)	0.73871 (14)	0.91260 (12)	0.0202 (3)
C10	0.42376 (16)	0.71324 (16)	0.84612 (13)	0.0238 (3)
C11	0.27415 (16)	0.87693 (17)	0.81639 (14)	0.0267 (3)
C12	0.31779 (16)	0.96808 (17)	0.69115 (14)	0.0273 (3)
C13	0.46872 (15)	0.99887 (15)	0.69690 (13)	0.0232 (3)
C14	0.64134 (14)	0.83880 (14)	0.66771 (12)	0.0192 (3)
H4	0.86150	0.34080	0.91350	0.0250*
H5	0.84390	0.10770	0.83880	0.0310*
H6	0.82740	0.07180	0.60030	0.0350*
H7	0.83330	0.26350	0.43400	0.0350*
H8	0.84990	0.49780	0.50780	0.0260*
H9A	0.60640	0.64490	0.97310	0.0240*
H9B	0.48930	0.84220	0.97700	0.0240*
H10A	0.48410	0.64340	0.75450	0.0280*
H10B	0.37790	0.65200	0.91250	0.0280*
H11A	0.18390	0.85290	0.79680	0.0320*
H11B	0.22550	0.95280	0.90490	0.0320*
H12A	0.21550	1.07700	0.68880	0.0330*
H12B	0.34380	0.90240	0.59990	0.0330*
H13A	0.45120	1.05050	0.79330	0.0280*
H13B	0.47140	1.07860	0.62450	0.0280*
H14A	0.73050	0.86640	0.61770	0.0230*
H14B	0.63500	0.76060	0.60190	0.0230*

	U11	U22	U33	U12	U13	U23
S1	0.0207 (2)	0.0261 (2)	0.0266 (2)	−0.0094 (1)	−0.0087 (1)	0.0025 (1)
N1	0.0189 (4)	0.0140 (4)	0.0172 (4)	−0.0087 (3)	−0.0049 (3)	0.0000 (3)
N2	0.0285 (5)	0.0188 (5)	0.0241 (5)	−0.0141 (4)	−0.0079 (4)	−0.0009 (4)
N3	0.0278 (5)	0.0208 (5)	0.0241 (5)	−0.0148 (4)	−0.0090 (4)	0.0004 (4)
C1	0.0234 (5)	0.0190 (5)	0.0158 (5)	−0.0129 (4)	−0.0058 (4)	0.0023 (4)
C2	0.0203 (5)	0.0136 (5)	0.0185 (5)	−0.0089 (4)	−0.0049 (4)	−0.0011 (4)
C3	0.0177 (5)	0.0148 (5)	0.0185 (5)	−0.0092 (4)	−0.0026 (4)	−0.0023 (4)
C4	0.0234 (5)	0.0192 (5)	0.0199 (5)	−0.0112 (4)	−0.0037 (4)	0.0006 (4)
C5	0.0301 (6)	0.0187 (5)	0.0303 (6)	−0.0149 (5)	−0.0033 (5)	0.0030 (5)
C6	0.0374 (7)	0.0225 (6)	0.0336 (7)	−0.0193 (5)	−0.0051 (5)	−0.0056 (5)
C7	0.0412 (7)	0.0293 (7)	0.0226 (6)	−0.0205 (6)	−0.0059 (5)	−0.0058 (5)
C8	0.0290 (6)	0.0212 (5)	0.0176 (5)	−0.0141 (5)	−0.0033 (4)	−0.0003 (4)
C9	0.0230 (5)	0.0207 (5)	0.0161 (5)	−0.0102 (4)	−0.0024 (4)	0.0002 (4)
C10	0.0254 (6)	0.0265 (6)	0.0236 (6)	−0.0168 (5)	−0.0015 (5)	−0.0014 (5)
C11	0.0209 (5)	0.0338 (7)	0.0259 (6)	−0.0137 (5)	−0.0034 (5)	−0.0030 (5)
C12	0.0221 (6)	0.0311 (6)	0.0259 (6)	−0.0093 (5)	−0.0082 (5)	0.0009 (5)
C13	0.0248 (6)	0.0188 (5)	0.0246 (6)	−0.0085 (4)	−0.0076 (5)	0.0031 (4)
C14	0.0214 (5)	0.0182 (5)	0.0191 (5)	−0.0100 (4)	−0.0050 (4)	0.0032 (4)

S1—C1	1.6364 (13)	C13—C14	1.5325 (18)
N1—C1	1.3357 (18)	C4—H4	0.9500
N1—C2	1.4750 (15)	C5—H5	0.9500
N1—C3	1.4359 (15)	C6—H6	0.9500
N2—N3	1.2506 (17)	C7—H7	0.9500
N2—C2	1.4786 (17)	C8—H8	0.9500
N3—C1	1.4707 (15)	C9—H9A	0.9900
C2—C9	1.5406 (19)	C9—H9B	0.9900
C2—C14	1.5356 (16)	C10—H10A	0.9900
C3—C4	1.3867 (16)	C10—H10B	0.9900
C3—C8	1.3874 (16)	C11—H11A	0.9900
C4—C5	1.3904 (18)	C11—H11B	0.9900
C5—C6	1.387 (2)	C12—H12A	0.9900
C6—C7	1.3859 (19)	C12—H12B	0.9900
C7—C8	1.392 (2)	C13—H13A	0.9900
C9—C10	1.537 (2)	C13—H13B	0.9900
C10—C11	1.532 (2)	C14—H14A	0.9900
C11—C12	1.5264 (19)	C14—H14B	0.9900
C12—C13	1.531 (2)
C1—N1—C2	110.52 (10)	C6—C7—H7	120.00
C1—N1—C3	124.94 (10)	C8—C7—H7	120.00
C2—N1—C3	123.30 (11)	C3—C8—H8	120.00
N3—N2—C2	112.14 (10)	C7—C8—H8	121.00
N2—N3—C1	110.00 (11)	C2—C9—H9A	108.00
S1—C1—N1	131.05 (9)	C2—C9—H9B	108.00
S1—C1—N3	122.55 (10)	C10—C9—H9A	108.00
N1—C1—N3	106.39 (10)	C10—C9—H9B	108.00
N1—C2—N2	100.93 (10)	H9A—C9—H9B	107.00
N1—C2—C9	112.71 (9)	C9—C10—H10A	109.00
N1—C2—C14	111.24 (9)	C9—C10—H10B	109.00
N2—C2—C9	108.93 (9)	C11—C10—H10A	109.00
N2—C2—C14	107.14 (9)	C11—C10—H10B	109.00
C9—C2—C14	114.78 (11)	H10A—C10—H10B	108.00
N1—C3—C4	118.50 (10)	C10—C11—H11A	108.00
N1—C3—C8	120.00 (10)	C10—C11—H11B	108.00
C4—C3—C8	121.47 (11)	C12—C11—H11A	108.00
C3—C4—C5	119.06 (11)	C12—C11—H11B	108.00
C4—C5—C6	119.93 (12)	H11A—C11—H11B	107.00
C5—C6—C7	120.60 (13)	C11—C12—H12A	109.00
C6—C7—C8	119.93 (12)	C11—C12—H12B	109.00
C3—C8—C7	118.98 (11)	C13—C12—H12A	108.00
C2—C9—C10	115.55 (10)	C13—C12—H12B	108.00
C9—C10—C11	113.31 (11)	H12A—C12—H12B	108.00
C10—C11—C12	115.62 (12)	C12—C13—H13A	109.00
C11—C12—C13	115.09 (12)	C12—C13—H13B	109.00
C12—C13—C14	112.85 (11)	C14—C13—H13A	109.00
C2—C14—C13	114.07 (9)	C14—C13—H13B	109.00
C3—C4—H4	120.00	H13A—C13—H13B	108.00
C5—C4—H4	120.00	C2—C14—H14A	109.00
C4—C5—H5	120.00	C2—C14—H14B	109.00
C6—C5—H5	120.00	C13—C14—H14A	109.00
C5—C6—H6	120.00	C13—C14—H14B	109.00
C7—C6—H6	120.00	H14A—C14—H14B	108.00
C2—N1—C1—S1	179.77 (9)	N1—C2—C9—C10	−93.43 (12)
C2—N1—C1—N3	−1.29 (12)	N2—C2—C9—C10	155.42 (10)
C3—N1—C1—S1	12.16 (18)	C14—C2—C9—C10	35.32 (14)
C3—N1—C1—N3	−168.90 (10)	N1—C2—C14—C13	173.50 (11)
C1—N1—C2—N2	0.83 (12)	N2—C2—C14—C13	−77.06 (14)
C1—N1—C2—C9	−115.21 (11)	C9—C2—C14—C13	44.03 (14)
C1—N1—C2—C14	114.23 (11)	N1—C3—C4—C5	176.23 (12)
C3—N1—C2—N2	168.68 (9)	C8—C3—C4—C5	−1.9 (2)
C3—N1—C2—C9	52.64 (14)	N1—C3—C8—C7	−176.32 (13)
C3—N1—C2—C14	−77.92 (14)	C4—C3—C8—C7	1.8 (2)
C1—N1—C3—C4	67.68 (16)	C3—C4—C5—C6	0.6 (2)
C1—N1—C3—C8	−114.17 (14)	C4—C5—C6—C7	0.7 (2)
C2—N1—C3—C4	−98.41 (14)	C5—C6—C7—C8	−0.9 (2)
C2—N1—C3—C8	79.74 (15)	C6—C7—C8—C3	−0.4 (2)
C2—N2—N3—C1	−0.83 (13)	C2—C9—C10—C11	−87.16 (13)
N3—N2—C2—N1	0.05 (13)	C9—C10—C11—C12	71.74 (14)
N3—N2—C2—C9	118.86 (11)	C10—C11—C12—C13	−52.16 (16)
N3—N2—C2—C14	−116.42 (11)	C11—C12—C13—C14	70.85 (14)
N2—N3—C1—S1	−179.60 (9)	C12—C13—C14—C2	−91.21 (13)
N2—N3—C1—N1	1.35 (13)