| Literature DB >> 24939217 |
Guilin Tang1, Sa A Wang2, Victoria Lu2, Hans Chulhee Lee3, Muzaffar H Qazilbash3, Xiaohong I Wang2, C Cameron Yin2, Robert Orlowski4, Yaping Wang5, Ankita Patel6, L Jeffrey Medeiros2, Gary Lu2.
Abstract
Newly emerged clonal cytogenetic abnormalities (CCA) in patients with prior cytotoxic therapy are highly concerning for therapy-related myeloid neoplasms (t-MN). In some patients, however, CCA appeared to be clinically "silent". In this study, we describe 25 patients who developed CCA after they received cytotoxic therapies for lymphoid neoplasms but never developed t-MN. These clinically "silent" CCA were always present as single abnormalities, often detected in a small subset of cells, and tended to disappear over time. We conclude that the occurrence of CCA is not always associated with t-MN. Clinical correlation is essential to guide a proper management of these patients.Entities:
Keywords: Bone marrow; Clonal cytogenetic abnormalities; Cytotoxic therapy; Silent; Therapy-related myeloid neoplasms
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Year: 2014 PMID： 24939217 DOI： 10.1016/j.leukres.2014.05.015
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156