| Literature DB >> 24938636 |
Kristen M Williams1, Danielle Dietzen, Abeer A Hassoun, Ilene Fennoy, Monica Bhatia.
Abstract
Allogenic hematopoietic cell transplantation (alloHCT) is currently the only curative treatment option for patients with sickle cell disease. Alemtuzumab is a monoclonal antibody directed against CD52 positive cells used in myeloablative conditioning regimens for alloHCT. Its use has been associated with development of autoimmune disease in adult patients with rheumatologic conditions. We report on three cases of new onset autoimmune thyroid disease after alloHCT treatment with alemtuzumab in pediatric patients with sickle cell disease.Entities:
Keywords: alemtuzumab; autoimmunity; sickle cell disease; stem cell transplant; thyroid dysfunction
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Year: 2014 PMID: 24938636 PMCID: PMC4440678 DOI: 10.1002/pbc.25102
Source DB: PubMed Journal: Pediatr Blood Cancer ISSN: 1545-5009 Impact factor: 3.167