Literature DB >> 2493801

Influence of BCG-induced immunity on the bactericidal activity of isoniazid and rifampicin in experimental tuberculosis of the mouse and guinea-pig.

J Dhillon1, D A Mitchison.   

Abstract

The influence of previous BCG vaccination on the bactericidal activity of isoniazid and rifampicin has been studied using serial counts of viable tubercle bacilli in the spleens and lungs of mice and guinea-pigs infected intravenously with M. tuberculosis, strain H37Rv. In mice, BCG vaccination decreased the bactericidal activity of isoniazid in the spleen, but did not affect its activity in the lungs, where immunity is less strongly expressed. BCG did not influence the bactericidal activity of rifampicin in either organ. In contrast, previous BCG vaccination in the guinea-pig increased the bactericidal activity of isoniazid and rifampicin in the spleen and lungs. The differences between the animal species might result from the immune response being mainly bacteriostatic in the mouse but bactericidal in the guinea-pig.

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Year:  1989        PMID： 2493801      PMCID： PMC2040531     

Source DB:  PubMed          Journal:  Br J Exp Pathol        ISSN： 0007-1021


  8 in total

1.  VIRULENCE IN THE GUINEA-PIG, SUSCEPTIBILITY TO HYDROGEN PEROXIDE, AND CATALASE ACTIVITY OF ISONIAZID-SENSITIVE TUBERCLE BACILLI FROM SOUTH INDIAN AND BRITISH PATIENTS.

Authors:  D A MITCHISON; J B SELKON; J LLOYD
Journal:  J Pathol Bacteriol       Date:  1963-10

2.  THE VIRULENCE OF TUBERCLE BACILLI FROM PATIENTS WITH PULMONARY TUBERCULOSIS IN INDIA AND OTHER COUNTRIES.

Authors:  D A MITCHISON
Journal:  Bull Int Union Tuberc       Date:  1964-09

3.  Analysis of the host-parasite equilibrium in chronic murine tuberculosis by total and viable bacillary counts.

Authors:  R J REES; P D HART
Journal:  Br J Exp Pathol       Date:  1961-02

4.  The in vitro action of antituberculous agents against multiplying and non-multiplying microbial cells.

Authors:  G L HOBBY; T F LENERT
Journal:  Am Rev Tuberc       Date:  1957-12

5.  The effects of some sulfhydryl compounds on growth of catalase-positive and catalase-negative tubercle bacilli.

Authors:  C M COLEMAN; G MIDDLEBROOK
Journal:  Am Rev Tuberc       Date:  1956-07

6.  The virulence in the guinea-pig of tubercle bacilli isolated before treatment from South Indian patients with pulmonary tuberculosis. 3. Virulence related to pretreatment status of disease and to response to chemotherapy.

Authors:  C V RAMAKRISHNAN; A L BHATIA; W FOX; D A MITCHISON; S RADHAKRISHNA; J B SELKON; J B SELKON; T V SUBBAIAH; S VELU; J G WALLACE
Journal:  Bull World Health Organ       Date:  1961       Impact factor: 9.408

Review 7.  Macrophage antimycobacterial mechanisms.

Authors:  D B Lowrie; P W Andrew
Journal:  Br Med Bull       Date:  1988-07       Impact factor: 4.291

8.  Experimental models to explain the high sterilizing activity of rifampin in the chemotherapy of tuberculosis.

Authors:  J M Dickinson; D A Mitchison
Journal:  Am Rev Respir Dis       Date:  1981-04
  8 in total
  5 in total

1.  Drug treatment combined with BCG vaccination reduces disease reactivation in guinea pigs infected with Mycobacterium tuberculosis.

Authors:  Shaobin Shang; Crystal A Shanley; Megan L Caraway; Eileen A Orme; Marcela Henao-Tamayo; Laurel Hascall-Dove; David Ackart; Ian M Orme; Diane J Ordway; Randall J Basaraba
Journal:  Vaccine       Date:  2012-01-11       Impact factor: 3.641

2.  Rifampin increases cytokine-induced expression of the CD1b molecule in human peripheral blood monocytes.

Authors:  L Tentori; G Graziani; S A Porcelli; M Sugita; M B Brenner; R Madaio; E Bonmassar; A Giuliani; A Aquino
Journal:  Antimicrob Agents Chemother       Date:  1998-03       Impact factor: 5.191

3.  Increased expression of host iron-binding proteins precedes iron accumulation and calcification of primary lung lesions in experimental tuberculosis in the guinea pig.

Authors:  Randall J Basaraba; Helle Bielefeldt-Ohmann; Ellie K Eschelbach; Claire Reisenhauer; Airn E Tolnay; Lauren C Taraba; Crystal A Shanley; Erin A Smith; Cathy L Bedwell; Elizabeth A Chlipala; Ian M Orme
Journal:  Tuberculosis (Edinb)       Date:  2007-10-17       Impact factor: 3.131

4.  Historical BCG vaccination combined with drug treatment enhances inhibition of mycobacterial growth ex vivo in human peripheral blood cells.

Authors:  Satria A Prabowo; Andrea Zelmer; Lisa Stockdale; Utkarsh Ojha; Steven G Smith; Karin Seifert; Helen A Fletcher
Journal:  Sci Rep       Date:  2019-03-19       Impact factor: 4.379

Review 5.  Therapeutic Vaccines for Tuberculosis: An Overview.

Authors:  Rania Bouzeyen; Babak Javid
Journal:  Front Immunol       Date:  2022-06-24       Impact factor: 8.786
  5 in total

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