Omar Choudhri1, Abdullah Feroze1, Peter Hwang2, Hannes Vogel3, Abdulrazag Ajlan1, Griffith Harsh4. 1. Department of Neurosurgery, Division of Neuropathology, Stanford University School of Medicine, Stanford, California, USA. 2. Department of Otolaryngology, Head & Neck Surgery, Division of Neuropathology, Stanford University School of Medicine, Stanford, California, USA. 3. Department of Pathology, Division of Neuropathology, Stanford University School of Medicine, Stanford, California, USA. 4. Department of Neurosurgery, Division of Neuropathology, Stanford University School of Medicine, Stanford, California, USA; Department of Otolaryngology, Head & Neck Surgery, Division of Neuropathology, Stanford University School of Medicine, Stanford, California, USA. Electronic address: gharsh@stanford.edu.
Abstract
OBJECTIVE: To report the first complete resection of a giant ecchordosis physaliphora using an endoscopic transclival approach and to provide a current review of the literature. METHODS: This rare benign lesion, originating from embryonic notochordal remnants, was located in the prepontine cistern of a 63-year-old man presenting with progressive tremor and imbalance. Preoperative imaging demonstrated a 2.1-cm intradural lesion abutting the pons and basilar artery and extending through the dura mater. RESULTS: A gross total resection was successfully achieved endoscopically without neurovascular compromise or additional complications. Postoperative histopathologic examination was consistent with a diagnosis of giant ecchordosis physaliphora. CONCLUSIONS: An endoscopic endonasal transclival approach provided a direct, minimally invasive route for safe and complete resection of this rare prepontine tumor, as it has for similarly located skull base chordomas. Our experience highlights the utility of endoscopy in visualization of both pathologic entities and nearby critical neurovascular structures in the management of ecchordosis physaliphora and other cranial base neoplasms.
OBJECTIVE: To report the first complete resection of a giant ecchordosis physaliphora using an endoscopic transclival approach and to provide a current review of the literature. METHODS: This rare benign lesion, originating from embryonic notochordal remnants, was located in the prepontine cistern of a 63-year-old man presenting with progressive tremor and imbalance. Preoperative imaging demonstrated a 2.1-cm intradural lesion abutting the pons and basilar artery and extending through the dura mater. RESULTS: A gross total resection was successfully achieved endoscopically without neurovascular compromise or additional complications. Postoperative histopathologic examination was consistent with a diagnosis of giant ecchordosis physaliphora. CONCLUSIONS: An endoscopic endonasal transclival approach provided a direct, minimally invasive route for safe and complete resection of this rare prepontine tumor, as it has for similarly located skull base chordomas. Our experience highlights the utility of endoscopy in visualization of both pathologic entities and nearby critical neurovascular structures in the management of ecchordosis physaliphora and other cranial base neoplasms.