Vincent P W Scholtes1, Wouter Peeters1, Guus W van Lammeren1, Dominic P J Howard2, Jean-Paul P M de Vries3, Gert Jan de Borst4, Jessica N Redgrave2, Hans Kemperman5, Casper G Schalkwijk6, Hester M den Ruijter7, Dominique P V de Kleijn1, Frans L Moll4, Peter M Rothwell2, Gerard Pasterkamp8. 1. Experimental Cardiology Laboratory, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands. 2. Department of Clinical Neurology, Stroke Prevention Research Unit, Radcliffe Infirmary, Oxford, UK. 3. Department of Vascular Surgery, St Antonius Hospital, Nieuwegein, The Netherlands. 4. Department of Vascular Surgery, University Medical Center Utrecht, Utrecht, The Netherlands. 5. Department of Clinical Chemistry, University Medical Center Utrecht, Utrecht, The Netherlands. 6. Department of Internal Medicine, Laboratory of Metabolism and Vascular Medicine, Maastricht, The Netherlands; Cardiovascular Research Institute, Maastricht University Medical Center, Maastricht, The Netherlands. 7. Experimental Cardiology Laboratory, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands. 8. Experimental Cardiology Laboratory, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands. Electronic address: g.pasterkamp@umcutrecht.nl.
Abstract
AIMS: Diabetes accelerates progression of atherosclerotic disease, but data on associations between diabetes and advanced atherosclerotic plaque composition are scarce. METHODS AND RESULTS: We used one of the largest biobanks, the Athero-Express study (n=1455) at carotid endarterectomy (CEA). All plaques were subjected to histological analysis to assess lipid core size, collagen, macrophages, smooth muscle cells, micro-vessel density and calcifications. In addition, within a subset of patients cytokines and chemokines were assessed. The 295 patients (20%) with type-2 diabetes showed a higher proportion of previous cardiovascular interventions and more stringent treatment for hypertension and hypercholesterolaemia compared with patients without type-2 diabetes. Surprisingly, no associations between diabetes and histological plaque characteristics were observed. In addition, no differences were observed in the expression of inflammatory chemokines, cytokines or advanced glycation end products in plaques of diabetic and non-diabetic patients. CONCLUSION: In patients suffering from significant carotid artery disease, diabetes does not appear to be associated with specific atherosclerotic plaque characteristics.
AIMS: Diabetes accelerates progression of atherosclerotic disease, but data on associations between diabetes and advanced atherosclerotic plaque composition are scarce. METHODS AND RESULTS: We used one of the largest biobanks, the Athero-Express study (n=1455) at carotid endarterectomy (CEA). All plaques were subjected to histological analysis to assess lipid core size, collagen, macrophages, smooth muscle cells, micro-vessel density and calcifications. In addition, within a subset of patients cytokines and chemokines were assessed. The 295 patients (20%) with type-2 diabetes showed a higher proportion of previous cardiovascular interventions and more stringent treatment for hypertension and hypercholesterolaemia compared with patients without type-2 diabetes. Surprisingly, no associations between diabetes and histological plaque characteristics were observed. In addition, no differences were observed in the expression of inflammatory chemokines, cytokines or advanced glycation end products in plaques of diabetic and non-diabeticpatients. CONCLUSION: In patients suffering from significant carotid artery disease, diabetes does not appear to be associated with specific atherosclerotic plaque characteristics.
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