Literature DB >> 24937456

GNAQ/11 mutations in uveal melanoma: is YAP the key to targeted therapy?

Matthew G Field1, J William Harbour2.   

Abstract

GNAQ and GNA11 are frequently mutated in uveal melanoma, but they remain difficult therapeutic targets. In this issue of Cancer Cell, Feng and colleagues and Yu and colleagues demonstrate that the oncogenic activity of mutant GNAQ/11 is mediated at least in part through YAP, potentially uncovering a new therapeutic strategy.
Copyright © 2014 Elsevier Inc. All rights reserved.

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Year:  2014        PMID： 24937456      PMCID： PMC4966161          DOI： 10.1016/j.ccr.2014.05.028

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  11 in total

Review 1.  The genetics of uveal melanoma: an emerging framework for targeted therapy.

Authors:  J William Harbour
Journal:  Pigment Cell Melanoma Res       Date:  2012-02-13       Impact factor: 4.693

2.  Frequent mutation of BAP1 in metastasizing uveal melanomas.

Authors:  J William Harbour; Michael D Onken; Elisha D O Roberson; Shenghui Duan; Li Cao; Lori A Worley; M Laurin Council; Katie A Matatall; Cynthia Helms; Anne M Bowcock
Journal:  Science       Date:  2010-11-04       Impact factor: 47.728

3.  Identification of unique MEK-dependent genes in GNAQ mutant uveal melanoma involved in cell growth, tumor cell invasion, and MEK resistance.

Authors:  Grazia Ambrosini; Christine A Pratilas; Li-Xuan Qin; Madhavi Tadi; Oliver Surriga; Richard D Carvajal; Gary K Schwartz
Journal:  Clin Cancer Res       Date:  2012-05-01       Impact factor: 12.531

4.  Mutations in GNA11 in uveal melanoma.

Authors:  Catherine D Van Raamsdonk; Klaus G Griewank; Michelle B Crosby; Maria C Garrido; Swapna Vemula; Thomas Wiesner; Anna C Obenauf; Werner Wackernagel; Gary Green; Nancy Bouvier; M Mert Sozen; Gail Baimukanova; Ritu Roy; Adriana Heguy; Igor Dolgalev; Raya Khanin; Klaus Busam; Michael R Speicher; Joan O'Brien; Boris C Bastian
Journal:  N Engl J Med       Date:  2010-11-17       Impact factor: 91.245

5.  Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP.

Authors:  Yi Liu-Chittenden; Bo Huang; Joong Sup Shim; Qian Chen; Se-Jin Lee; Robert A Anders; Jun O Liu; Duojia Pan
Journal:  Genes Dev       Date:  2012-06-07       Impact factor: 11.361

6.  A genome-wide RNAi screen reveals a Trio-regulated Rho GTPase circuitry transducing mitogenic signals initiated by G protein-coupled receptors.

Authors:  Jose P Vaqué; Robert T Dorsam; Xiaodong Feng; Ramiro Iglesias-Bartolome; David J Forsthoefel; Qianming Chen; Anne Debant; Mark A Seeger; Bruce R Ksander; Hidemi Teramoto; J Silvio Gutkind
Journal:  Mol Cell       Date:  2012-11-21       Impact factor: 17.970

7.  Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry.

Authors:  Xiaodong Feng; Maria Sol Degese; Ramiro Iglesias-Bartolome; Jose P Vaque; Alfredo A Molinolo; Murilo Rodrigues; M Raza Zaidi; Bruce R Ksander; Glenn Merlino; Akrit Sodhi; Qianming Chen; J Silvio Gutkind
Journal:  Cancer Cell       Date:  2014-05-29       Impact factor: 31.743

8.  Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP.

Authors:  Fa-Xing Yu; Jing Luo; Jung-Soon Mo; Guangbo Liu; Young Chul Kim; Zhipeng Meng; Ling Zhao; Gholam Peyman; Hong Ouyang; Wei Jiang; Jiagang Zhao; Xu Chen; Liangfang Zhang; Cun-Yu Wang; Boris C Bastian; Kang Zhang; Kun-Liang Guan
Journal:  Cancer Cell       Date:  2014-05-29       Impact factor: 31.743

9.  The protein kinase C inhibitor enzastaurin exhibits antitumor activity against uveal melanoma.

Authors:  Xinqi Wu; Meijun Zhu; Jonathan A Fletcher; Anita Giobbie-Hurder; F Stephen Hodi
Journal:  PLoS One       Date:  2012-01-12       Impact factor: 3.240

10.  Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi.

Authors:  Catherine D Van Raamsdonk; Vladimir Bezrookove; Gary Green; Jürgen Bauer; Lona Gaugler; Joan M O'Brien; Elizabeth M Simpson; Gregory S Barsh; Boris C Bastian
Journal:  Nature       Date:  2008-12-10       Impact factor: 49.962
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  10 in total

1.  Verteporfin induces apoptosis and eliminates cancer stem-like cells in uveal melanoma in the absence of light activation.

Authors:  Ya-Wen Ma; Yi-Zhi Liu; Jing-Xuan Pan
Journal:  Am J Cancer Res       Date:  2016-12-01       Impact factor: 6.166

2.  Gα13 mediates human cytomegalovirus-encoded chemokine receptor US28-induced cell death in melanoma.

Authors:  Shripad Joshi; Christian Wels; Christine Beham-Schmid; Mizuho Fukunaga-Kalabis; Sheri L Holmen; Marcus Otte; Meenhard Herlyn; Maria Waldhoer; Helmut Schaider
Journal:  Int J Cancer       Date:  2015-03-16       Impact factor: 7.396

Review 3.  Emerging strategies to treat rare and intractable subtypes of melanoma.

Authors:  Gretchen M Alicea; Vito W Rebecca
Journal:  Pigment Cell Melanoma Res       Date:  2020-04-24       Impact factor: 4.693

Review 4.  Embryonic Zebrafish: Different Phenotypes after Injection of Human Uveal Melanoma Cells.

Authors:  Wietske van der Ent; Claudia Burrello; Mark J de Lange; Pieter A van der Velden; Aart G Jochemsen; Martine J Jager; B Ewa Snaar-Jagalska
Journal:  Ocul Oncol Pathol       Date:  2015-04-09

5.  An insight into the molecular genetics of a uveal melanoma patient cohort.

Authors:  Susan Kennedy; Michael Rice; Sinead Toomey; Noel Horgan; Bryan T Hennessey; Annemarie Larkin
Journal:  J Cancer Res Clin Oncol       Date:  2018-07-14       Impact factor: 4.553

6.  Yes-Associated Protein (YAP) Promotes Tumorigenesis in Melanoma Cells Through Stimulation of Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1).

Authors:  Huizi Xiong; Qian Yu; Yu Gong; Wenjuan Chen; Yunlei Tong; Yao Wang; Hui Xu; Yuling Shi
Journal:  Sci Rep       Date:  2017-11-14       Impact factor: 4.379

7.  An Ensemble Method to Predict Target Genes and Pathways in Uveal Melanoma.

Authors:  Chao Wei; Lei Wang; Han Zhang
Journal:  Open Life Sci       Date:  2018-04-10       Impact factor: 0.938

Review 8.  Context-dependent transcriptional regulations of YAP/TAZ in stem cell and differentiation.

Authors:  Juan Luo; Peng Li
Journal:  Stem Cell Res Ther       Date:  2022-01-10       Impact factor: 6.832

9.  A Subset of Nuclear Receptors are Uniquely Expressed in Uveal Melanoma Cells.

Authors:  Kenneth Edward Huffman; Ryan Carstens; Elisabeth D Martinez
Journal:  Front Endocrinol (Lausanne)       Date:  2015-07-07       Impact factor: 5.555

10.  Class III-specific HDAC inhibitor Tenovin-6 induces apoptosis, suppresses migration and eliminates cancer stem cells in uveal melanoma.

Authors:  Wei Dai; Jingfeng Zhou; Bei Jin; Jingxuan Pan
Journal:  Sci Rep       Date:  2016-03-04       Impact factor: 4.379
  10 in total

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