Ju-Han Lee1, Younghye Kim1, Jung-Woo Choi1, Young-Sik Kim2. 1. Department of Pathology, Korea University Ansan Hospital, Ansan, Republic of Korea. 2. Department of Pathology, Korea University Ansan Hospital, Ansan, Republic of Korea. Electronic address: apysk@korea.ac.kr.
Abstract
BACKGROUND AND AIMS: The prevalence and prognostic significance of Epstein-Barr virus (EBV) infection in classical Hodgkin's lymphomas (cHLs) remain elusive. To examine the epidemiological and prognostic differences between EBV-positive and -negative cHLs, we conducted a meta-analysis of 119 published studies including 13,045 cases. METHODS: We pooled the results of relevant published studies identified using the PubMed and Embase. The effect sizes of outcome parameters were calculated by prevalence, odds ratio (OR), or hazard ratio using a random-effects model. RESULTS: The pooled prevalence of EBV infection in cHL was 47.9%, which was significantly higher in Africa and Central and South America than other regions. EBV-positive cHL showed higher incidence in children than in adults (69.7 vs. 41.1%). EBV-positive cHL was significantly related to male (OR = 1.8, 95% CI: 1.510-2.038; p <0.001), mixed cellularity subtype (OR = 3.8, 95% CI: 3.243-4.451; p <0.001), and advanced clinical stages (OR = 1.2, 95% CI: 1.072-1.369; p = 0.002). However, the presence of EBV in cHL was not associated with overall or event-free survival. CONCLUSIONS: The prevalence of EBV differs according to age, sex, region, histologic subtype, and clinical stage of cHL. However, the presence of EBV has little effects on cHL patient's survival.
BACKGROUND AND AIMS: The prevalence and prognostic significance of Epstein-Barr virus (EBV) infection in classical Hodgkin's lymphomas (cHLs) remain elusive. To examine the epidemiological and prognostic differences between EBV-positive and -negative cHLs, we conducted a meta-analysis of 119 published studies including 13,045 cases. METHODS: We pooled the results of relevant published studies identified using the PubMed and Embase. The effect sizes of outcome parameters were calculated by prevalence, odds ratio (OR), or hazard ratio using a random-effects model. RESULTS: The pooled prevalence of EBV infection in cHL was 47.9%, which was significantly higher in Africa and Central and South America than other regions. EBV-positive cHL showed higher incidence in children than in adults (69.7 vs. 41.1%). EBV-positive cHL was significantly related to male (OR = 1.8, 95% CI: 1.510-2.038; p <0.001), mixed cellularity subtype (OR = 3.8, 95% CI: 3.243-4.451; p <0.001), and advanced clinical stages (OR = 1.2, 95% CI: 1.072-1.369; p = 0.002). However, the presence of EBV in cHL was not associated with overall or event-free survival. CONCLUSIONS: The prevalence of EBV differs according to age, sex, region, histologic subtype, and clinical stage of cHL. However, the presence of EBV has little effects on cHL patient's survival.
Authors: Mara M Epstein; Ellen T Chang; Yawei Zhang; Teresa T Fung; Julie L Batista; Richard F Ambinder; Tongzhang Zheng; Nancy E Mueller; Brenda M Birmann Journal: Am J Epidemiol Date: 2015-07-15 Impact factor: 4.897
Authors: Katherine D Westmoreland; Christopher C Stanley; Nathan D Montgomery; Bongani Kaimila; Edwards Kasonkanji; Nader Kim El-Mallawany; Peter Wasswa; Idah Mtete; Mercy Butia; Salama Itimu; Mary Chasela; Mary Mtunda; Maria Chikasema; Victor Makwakwa; Coxcilly Kampani; Bal M Dhungel; Marcia K Sanders; Robert Krysiak; Tamiwe Tomoka; N George Liomba; Dirk P Dittmer; Yuri Fedoriw; Satish Gopal Journal: Pediatr Blood Cancer Date: 2016-10-26 Impact factor: 3.167