| Literature DB >> 24935955 |
Charlene Wang1, Mohamed Abdel-Mohsen2, Matthew C Strain3, Steven M Lada3, Steven Yukl4, Leslie R Cockerham5, Christopher D Pilcher5, Frederick M Hecht5, Elizabeth Sinclair5, Teri Liegler5, Douglas D Richman3, Steven G Deeks5, Satish K Pillai2.
Abstract
Individuals who are heterozygous for the CCR5-Δ32 mutation provide a natural model to examine the effects of reduced CCR5 expression on human immunodeficiency virus (HIV) persistence. We evaluated the HIV reservoir in 18 CCR5-Δ32 heterozygotes and 54 CCR5 wild-type individuals during suppressive antiretroviral therapy. Cell-associated HIV RNA levels (P=.035), RNA to DNA transcriptional ratios (P=.013), and frequency of detectable HIV 2-long terminal repeat circular DNA (P=.013) were significantly lower in CD4+ T cells from CCR5-Δ32 heterozygotes. Cell-associated HIV RNA was significantly correlated with CCR5 surface expression on CD4+ T cells (r2=0.136; P=.002). Our findings suggest that curative strategies should further explore manipulation of CCR5.Entities:
Keywords: CCR5; HIV; HIV replication; HIV transcription; NF-κB; coreceptor; eradication; latency; reservoir; Δ32
Mesh：
Substances：
Year: 2014 PMID： 24935955 PMCID： PMC4271057 DOI： 10.1093/infdis/jiu338
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226