Literature DB >> 24934968

Biosynthesis of gold nanoparticles using Sargassum swartzii and its cytotoxicity effect on HeLa cells.

T Stalin Dhas1, V Ganesh Kumar2, V Karthick1, K Govindaraju1, T Shankara Narayana3.   

Abstract

In this investigation, biological synthesis of gold nanoparticles (AuNPs) using Sargassum swartzii and its cytotoxicity against human cervical carcinoma (HeLa) cells is reported. The biological synthesis involved the reduction of chloroauric acid led to the formation of AuNPs within 5min at 60°C and the formation of AuNPs was confirmed using UV-vis spectrophotometer. The AuNPs were stable; spherical in shape with well-defined dimensions, and the average size of the particle is 35nm. A zeta potential value of -27.6mV revealed synthesized AuNPs were highly stable. The synthesized AuNPs exhibited a dose-dependent cytotoxicity against human cervical carcinoma (HeLa) cells. Furthermore, induction of apoptosis was measured by DAPI (4',6-Diamidino-2-phenylindole dihydrochloride) staining.
Copyright © 2014 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Anticancer; Apoptosis; Gold nanoparticles; HeLa; Sargassum swartzii

Mesh：

Substances：

Year:  2014        PMID： 24934968     DOI： 10.1016/j.saa.2014.05.042

Source DB:  PubMed          Journal:  Spectrochim Acta A Mol Biomol Spectrosc        ISSN： 1386-1425            Impact factor:   4.098


  14 in total

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