Literature DB >> 24934509

Germinal center reaction: antigen affinity and presentation explain it all.

Michael A Oropallo1, Andrea Cerutti2.   

Abstract

The selection and expansion of B cells undergoing affinity maturation in the germinal center is a hallmark of humoral immunity. A recent paper in Nature provides new insights into the relationships between the affinity of the immunoglobulin receptor for antigen, the ability of B cells to present antigen to T cells, and the processes of selection, mutation, and clonal expansion in the germinal center.
Copyright © 2014 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Tfh cells; affinity maturation; antigen presentation; germinal center

Mesh：

Year:  2014        PMID： 24934509      PMCID： PMC4174395          DOI： 10.1016/j.it.2014.06.001

Source DB:  PubMed          Journal:  Trends Immunol        ISSN： 1471-4906            Impact factor:   16.687


  10 in total

1.  VARIATIONS IN AFFINITIES OF ANTIBODIES DURING THE IMMUNE RESPONSE.

Authors:  H N EISEN; G W SISKIND
Journal:  Biochemistry       Date:  1964-07       Impact factor: 3.162

Review 2.  Germinal centers.

Authors:  Gabriel D Victora; Michel C Nussenzweig
Journal:  Annu Rev Immunol       Date:  2012-01-03       Impact factor: 28.527

3.  Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter.

Authors:  Gabriel D Victora; Tanja A Schwickert; David R Fooksman; Alice O Kamphorst; Michael Meyer-Hermann; Michael L Dustin; Michel C Nussenzweig
Journal:  Cell       Date:  2010-11-12       Impact factor: 41.582

4.  Imaging of germinal center selection events during affinity maturation.

Authors:  Christopher D C Allen; Takaharu Okada; H Lucy Tang; Jason G Cyster
Journal:  Science       Date:  2006-12-21       Impact factor: 47.728

5.  In vivo imaging of germinal centres reveals a dynamic open structure.

Authors:  Tanja A Schwickert; Randall L Lindquist; Guy Shakhar; Geulah Livshits; Dimitris Skokos; Marie H Kosco-Vilbois; Michael L Dustin; Michel C Nussenzweig
Journal:  Nature       Date:  2007-01-31       Impact factor: 49.962

6.  Definition of germinal-center B cell migration in vivo reveals predominant intrazonal circulation patterns.

Authors:  Anja E Hauser; Tobias Junt; Thorsten R Mempel; Michael W Sneddon; Steven H Kleinstein; Sarah E Henrickson; Ulrich H von Andrian; Mark J Shlomchik; Ann M Haberman
Journal:  Immunity       Date:  2007-05       Impact factor: 31.745

Review 7.  Germinal-center organization and cellular dynamics.

Authors:  Christopher D C Allen; Takaharu Okada; Jason G Cyster
Journal:  Immunity       Date:  2007-08       Impact factor: 31.745

8.  Somatic mutation leads to efficient affinity maturation when centrocytes recycle back to centroblasts.

Authors:  M Oprea; A S Perelson
Journal:  J Immunol       Date:  1997-06-01       Impact factor: 5.422

Review 9.  Germinal centers.

Authors:  I C MacLennan
Journal:  Annu Rev Immunol       Date:  1994       Impact factor: 28.527

10.  Clonal selection in the germinal centre by regulated proliferation and hypermutation.

Authors:  Alexander D Gitlin; Ziv Shulman; Michel C Nussenzweig
Journal:  Nature       Date:  2014-05-04       Impact factor: 49.962
  10 in total
  18 in total

Review 1.  Checkpoints that control B cell development.

Authors:  Fritz Melchers
Journal:  J Clin Invest       Date:  2015-05-04       Impact factor: 14.808

2.  The Quantitative Assessment of the Secreted IgG Repertoire after Recall to Evaluate the Quality of Immunizations.

Authors:  Klaus Eyer; Carlos Castrillon; Guilhem Chenon; Jérôme Bibette; Pierre Bruhns; Andrew D Griffiths; Jean Baudry
Journal:  J Immunol       Date:  2020-07-15       Impact factor: 5.422

3.  Early T Follicular Helper Cell Responses and Germinal Center Reactions Are Associated with Viremia Control in Immunized Rhesus Macaques.

Authors:  Sabrina Helmold Hait; Diego A Vargas-Inchaustegui; Thomas Musich; Venkatramanan Mohanram; Iskra Tuero; David J Venzon; Jenifer Bear; Margherita Rosati; Monica Vaccari; Genoveffa Franchini; Barbara K Felber; George N Pavlakis; Marjorie Robert-Guroff
Journal:  J Virol       Date:  2019-02-05       Impact factor: 5.103

4.  HIV infection Worsens Age-Associated Defects in Antibody Responses to Influenza Vaccine.

Authors:  Varghese K George; Suresh Pallikkuth; Anita Parmigiani; Maria Alcaide; Margaret Fischl; Kristopher L Arheart; Savita Pahwa
Journal:  J Infect Dis       Date:  2015-01-02       Impact factor: 5.226

5.  Evaluation of Protective Efficacy of Selected Immunodominant B-Cell Epitopes within Virulent Surface Proteins of Streptococcus pneumoniae.

Authors:  Theodora Papastamatiou; John G Routsias; Olga Koutsoni; Eleni Dotsika; Athanassios Tsakris; Vana Spoulou
Journal:  Infect Immun       Date:  2018-02-20       Impact factor: 3.441

Review 6.  The Transcriptional Regulation of Germinal Center Formation.

Authors:  Shuang Song; Patrick D Matthias
Journal:  Front Immunol       Date:  2018-09-05       Impact factor: 7.561

7.  EAF2 mediates germinal centre B-cell apoptosis to suppress excessive immune responses and prevent autoimmunity.

Authors:  Yingqian Li; Yoshimasa Takahashi; Shin-ichiro Fujii; Yang Zhou; Rongjian Hong; Akari Suzuki; Takeshi Tsubata; Koji Hase; Ji-Yang Wang
Journal:  Nat Commun       Date:  2016-03-03       Impact factor: 14.919

Review 8.  Role of Bruton's tyrosine kinase in B cells and malignancies.

Authors:  Simar Pal Singh; Floris Dammeijer; Rudi W Hendriks
Journal:  Mol Cancer       Date:  2018-02-19       Impact factor: 27.401

Review 9.  The Complex Interplay between DNA Injury and Repair in Enzymatically Induced Mutagenesis and DNA Damage in B Lymphocytes.

Authors:  Mahnoush Bahjat; Jeroen E J Guikema
Journal:  Int J Mol Sci       Date:  2017-08-30       Impact factor: 5.923

Review 10.  Tertiary Lymphoid Structures: Autoimmunity Goes Local.

Authors:  Elena Pipi; Saba Nayar; David H Gardner; Serena Colafrancesco; Charlotte Smith; Francesca Barone
Journal:  Front Immunol       Date:  2018-09-12       Impact factor: 7.561
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