Literature DB >> 24933481

NOTCH and PTEN in prostate cancer.

Fred E Bertrand1, James A McCubrey2, C William Angus3, Jennifer M Nutter3, George Sigounas3.   

Abstract

Over the past decade, our understanding of the role that Notch-signaling has in tumorigenesis has shifted from leukemogenesis into cancers of solid tumors. Emerging data suggests that in addition to direct effects mediated through the canonical Notch pathway, Notch may participate in epithelial tumor development through regulation of pathways such as PTEN/PI3K/Akt. Prostate cancer is a disease for which PTEN gene expression is especially essential. This review will summarize a role for Notch in prostate development and cancer with an emphasis on how the Notch pathway may intersect with PTEN/PI3K/Akt and mTOR signaling.
Copyright © 2014 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  EMT; Epithelial; Mesenchymal; Metabolism; Microenvironment; Tumor; mTOR

Mesh：

Substances：

Year:  2014        PMID： 24933481     DOI： 10.1016/j.jbior.2014.05.002

Source DB:  PubMed          Journal:  Adv Biol Regul        ISSN： 2212-4926


  12 in total

Review 1.  The therapeutic potential of mTOR inhibitors in breast cancer.

Authors:  Linda S Steelman; Alberto M Martelli; Lucio Cocco; Massimo Libra; Ferdinando Nicoletti; Stephen L Abrams; James A McCubrey
Journal:  Br J Clin Pharmacol       Date:  2016-05-10       Impact factor: 4.335

2.  Regulation of PTEN degradation and NEDD4-1 E3 ligase activity by Numb.

Authors:  Chen Shao; Zhiguo Li; Nihal Ahmad; Xiaoqi Liu
Journal:  Cell Cycle       Date:  2017-04-24       Impact factor: 4.534

Review 3.  The role of GATA2 in lethal prostate cancer aggressiveness.

Authors:  Veronica Rodriguez-Bravo; Marc Carceles-Cordon; Yujin Hoshida; Carlos Cordon-Cardo; Matthew D Galsky; Josep Domingo-Domenech
Journal:  Nat Rev Urol       Date:  2016-11-22       Impact factor: 14.432

4.  The Y-located proto-oncogene TSPY exacerbates and its X-homologue TSPX inhibits transactivation functions of androgen receptor and its constitutively active variants.

Authors:  Yunmin Li; Dong Ji Zhang; Yun Qiu; Tatsuo Kido; Yun-Fai Chris Lau
Journal:  Hum Mol Genet       Date:  2017-03-01       Impact factor: 6.150

5.  MicroRNA-21 promotes cell proliferation, migration, and resistance to apoptosis through PTEN/PI3K/AKT signaling pathway in esophageal cancer.

Authors:  Yan-Ran Wu; Hai-Jun Qi; Dan-Fang Deng; Ying-Ying Luo; Sheng-Lan Yang
Journal:  Tumour Biol       Date:  2016-05-17

Review 6.  Notch signaling in prostate cancer: refining a therapeutic opportunity.

Authors:  Qingtai Su; Li Xin
Journal:  Histol Histopathol       Date:  2015-11-02       Impact factor: 2.303

7.  NUMB and NUMBL differences in gene regulation.

Authors:  José Manuel García-Heredia; Amancio Carnero
Journal:  Oncotarget       Date:  2018-01-11

8.  Piwi-interacting RNA-651 promotes cell proliferation and migration and inhibits apoptosis in breast cancer by facilitating DNMT1-mediated PTEN promoter methylation.

Authors:  Ting Liu; Juan Wang; Lei Sun; Miao Li; Xin He; Jue Jiang; Qi Zhou
Journal:  Cell Cycle       Date:  2021-07-27       Impact factor: 5.173

9.  Palmitoylated claudin7 captured in glycolipid-enriched membrane microdomains promotes metastasis via associated transmembrane and cytosolic molecules.

Authors:  Florian Thuma; Sarah Heiler; Martina Schnölzer; Margot Zöller
Journal:  Oncotarget       Date:  2016-05-24

10.  PTEN mediates Notch-dependent stalk cell arrest in angiogenesis.

Authors:  Helena Serra; Iñigo Chivite; Ana Angulo-Urarte; Adriana Soler; James D Sutherland; Amaia Arruabarrena-Aristorena; Anan Ragab; Radiance Lim; Marcos Malumbres; Marcus Fruttiger; Michael Potente; Manuel Serrano; Àngels Fabra; Francesc Viñals; Oriol Casanovas; Pier Paolo Pandolfi; Anna Bigas; Arkaitz Carracedo; Holger Gerhardt; Mariona Graupera
Journal:  Nat Commun       Date:  2015-07-31       Impact factor: 14.919
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