Hoon-Ki Min1,2,3, Erika K Ross1, Kendall H Lee1,2, Kendall Dennis3, Seong Rok Han1,4, Ju Ho Jeong1,5, Michael P Marsh1, Bryan Striemer6, Joel P Felmlee6, J Luis Lujan1,2,3, Steve Goerss1, Penelope S Duffy1, Charles Blaha7, Su-Youne Chang1,2, Kevin E Bennet1,3. 1. Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, USA. 2. Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA. 3. Division of Engineering, Mayo Clinic, Rochester, Minnesota, USA. 4. Department of Neurosurgery, Ilsan Paik Hospital, College of Medicine, Inje University, Goyang, Republic of Korea. 5. Department of Neurosurgery, Kosin University Gospel Hospital, Busan, Republic of Korea. 6. Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA. 7. Department of Psychology, University of Memphis, Memphis, Tennessee, USA.
Abstract
BACKGROUND: Functional magnetic resonance imaging (fMRI) is a powerful method for identifying in vivo network activation evoked by deep brain stimulation (DBS). OBJECTIVE: Identify the global neural circuitry effect of subthalamic nucleus (STN) DBS in nonhuman primates (NHP). METHOD: An in-house developed MR image-guided stereotactic targeting system delivered a mini-DBS stimulating electrode, and blood oxygenation level-dependent (BOLD) activation during STN DBS in healthy NHP was measured by combining fMRI with a normalized functional activation map and general linear modeling. RESULTS: STN DBS significantly increased BOLD activation in the sensorimotor cortex, supplementary motor area, caudate nucleus, pedunculopontine nucleus, cingulate, insular cortex, and cerebellum (FDR < 0.001). CONCLUSION: Our results demonstrate that STN DBS evokes neural network grouping within the motor network and the basal ganglia. Taken together, these data highlight the importance and specificity of neural circuitry activation patterns and functional connectivity.
BACKGROUND: Functional magnetic resonance imaging (fMRI) is a powerful method for identifying in vivo network activation evoked by deep brain stimulation (DBS). OBJECTIVE: Identify the global neural circuitry effect of subthalamic nucleus (STN) DBS in nonhuman primates (NHP). METHOD: An in-house developed MR image-guided stereotactic targeting system delivered a mini-DBS stimulating electrode, and blood oxygenation level-dependent (BOLD) activation during STN DBS in healthy NHP was measured by combining fMRI with a normalized functional activation map and general linear modeling. RESULTS:STN DBS significantly increased BOLD activation in the sensorimotor cortex, supplementary motor area, caudate nucleus, pedunculopontine nucleus, cingulate, insular cortex, and cerebellum (FDR < 0.001). CONCLUSION: Our results demonstrate that STN DBS evokes neural network grouping within the motor network and the basal ganglia. Taken together, these data highlight the importance and specificity of neural circuitry activation patterns and functional connectivity.
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