Almir G V Bitencourt1, Eduardo N P Lima2, Rubens Chojniak3, Elvira F Marques4, Juliana A Souza5, Wesley P Andrade6, Marcos D Guimarães7. 1. Department of Diagnostic Imaging, Hospital A.C. Camargo, Fundação Antônio Prudente, R. Professor Antônio Prudente, 211, CEP: 01509-010 São Paulo, Brazil. Electronic address: almirgvb@yahoo.com.br. 2. Department of Diagnostic Imaging, Hospital A.C. Camargo, Fundação Antônio Prudente, R. Professor Antônio Prudente, 211, CEP: 01509-010 São Paulo, Brazil. Electronic address: e.lima-nuclear2@uol.com.br. 3. Department of Diagnostic Imaging, Hospital A.C. Camargo, Fundação Antônio Prudente, R. Professor Antônio Prudente, 211, CEP: 01509-010 São Paulo, Brazil. Electronic address: chojniak@uol.com.br. 4. Department of Diagnostic Imaging, Hospital A.C. Camargo, Fundação Antônio Prudente, R. Professor Antônio Prudente, 211, CEP: 01509-010 São Paulo, Brazil. Electronic address: elvira.marques@ig.com.br. 5. Department of Diagnostic Imaging, Hospital A.C. Camargo, Fundação Antônio Prudente, R. Professor Antônio Prudente, 211, CEP: 01509-010 São Paulo, Brazil. Electronic address: julianaalves79@hotmail.com. 6. Department of Mastology, Hospital A.C. Camargo, Fundação Antônio Prudente, R. Professor Antônio Prudente, 211, CEP: 01509-010 São Paulo, Brazil. Electronic address: wesley.andrade@hotmail.com. 7. Department of Diagnostic Imaging, Hospital A.C. Camargo, Fundação Antônio Prudente, R. Professor Antônio Prudente, 211, CEP: 01509-010 São Paulo, Brazil. Electronic address: marcosduarte500@gmail.com.
Abstract
OBJECTIVE: To evaluate the impact of adding 18F-fluorine-2-deoxy-d-glucose (FDG) positron emission tomography (PET) in the evaluation of suspicious breast lesions on magnetic resonance imaging (MRI). METHODS: Sixty patients with suspicious breast lesions on MRI were selected to perform a PET-CT in prone position, dedicated to the evaluation of the breasts. The areas with increased 18F-FDG concentration relative to normal parenchyma were considered positive on PET-CT. Fusion of PET and MRI images (PET-MRI) was performed on a dedicated workstation to better locate corresponding lesions, and its findings were compared with histological results. RESULTS: 76 lesions were evaluated, including 64 mass lesions (84.2%) and 12 non-mass lesions (15.8%). Lesions' mean diameter on MRI was 29.6 ± 19.2 mm (range 6-94 mm). PET-CT showed increased metabolically activity on 57 lesions (75.0%), with mean maximum SUV of 5.7 ± 5.0 (range 0.8-23.1). On histopathology, there were 17 (22.4%) benign and 59 (79.7%) malignant lesions. Considering all lesions, PET-MRI fusion provided 89.8% sensitivity, 76.5% specificity and 86.8% accuracy. Considering only mass lesions higher than 10mm, PET-MRI fusion provided 95.8% sensitivity, 83.3% specificity and 93.3% accuracy. CONCLUSION: The inclusion of 18F-FDG PET on the evaluation of suspicious breast lesions on MRI helped to differentiate benign from malignant breast lesions, especially for mass lesions with a diameter higher than 10 mm.
OBJECTIVE: To evaluate the impact of adding 18F-fluorine-2-deoxy-d-glucose (FDG) positron emission tomography (PET) in the evaluation of suspicious breast lesions on magnetic resonance imaging (MRI). METHODS: Sixty patients with suspicious breast lesions on MRI were selected to perform a PET-CT in prone position, dedicated to the evaluation of the breasts. The areas with increased 18F-FDG concentration relative to normal parenchyma were considered positive on PET-CT. Fusion of PET and MRI images (PET-MRI) was performed on a dedicated workstation to better locate corresponding lesions, and its findings were compared with histological results. RESULTS: 76 lesions were evaluated, including 64 mass lesions (84.2%) and 12 non-mass lesions (15.8%). Lesions' mean diameter on MRI was 29.6 ± 19.2 mm (range 6-94 mm). PET-CT showed increased metabolically activity on 57 lesions (75.0%), with mean maximum SUV of 5.7 ± 5.0 (range 0.8-23.1). On histopathology, there were 17 (22.4%) benign and 59 (79.7%) malignant lesions. Considering all lesions, PET-MRI fusion provided 89.8% sensitivity, 76.5% specificity and 86.8% accuracy. Considering only mass lesions higher than 10mm, PET-MRI fusion provided 95.8% sensitivity, 83.3% specificity and 93.3% accuracy. CONCLUSION: The inclusion of 18F-FDG PET on the evaluation of suspicious breast lesions on MRI helped to differentiate benign from malignant breast lesions, especially for mass lesions with a diameter higher than 10 mm.
Authors: Maria J Garcia-Velloso; Maria J Ribelles; Macarena Rodriguez; Alejandro Fernandez-Montero; Lidia Sancho; Elena Prieto; Marta Santisteban; Natalia Rodriguez-Spiteri; Miguel A Idoate; Fernando Martinez-Regueira; Arlette Elizalde; Luis J Pina Journal: Eur Radiol Date: 2016-12-21 Impact factor: 5.315
Authors: Amy M Fowler; Manoj Kumar; Leah Henze Bancroft; Kelley Salem; Jacob M Johnson; Jillian Karow; Scott B Perlman; Tyler J Bradshaw; Samuel A Hurley; Alan B McMillan; Roberta M Strigel Journal: Radiol Imaging Cancer Date: 2021-01-15
Authors: Almir G V Bitencourt; Eduardo N P Lima; Rubens Chojniak; Elvira F Marques; Juliana A Souza; Wesley P Andrade; Marcos D Guimarães Journal: Medicine (Baltimore) Date: 2014-11 Impact factor: 1.889