| Literature DB >> 24931918 |
D van Duin1, E D Cober, S S Richter, F Perez, M Cline, K S Kaye, R C Kalayjian, R A Salata, S R Evans, V G Fowler, R A Bonomo.
Abstract
Carbapenem-resistant Klebsiella pneumoniae (CRKP) is an increasing global threat. Here, we describe the prevalence and impact of tigecycline use in a cohort of patients with CRKP bacteriuria nested within a multicentre, prospective study. In the 21-month study period, 260 unique patients were included. Tigecycline was given to 80 (31%) patients. The use of tigecycline during the index hospitalization was significantly associated with the subsequent development of tigecycline resistance in the same patient (OR, 6.13; 95% CI, 1.15-48.65; p 0.03). In conclusion, the use of tigecycline with CRKP bacteriuria is common, and is associated with the subsequent development of tigecycline resistance.Entities:
Keywords: Carbapenem-resistant Enterobacteriaceae; multidrug resistance; urinary tract infection
Mesh:
Substances:
Year: 2014 PMID: 24931918 PMCID: PMC4265572 DOI: 10.1111/1469-0691.12714
Source DB: PubMed Journal: Clin Microbiol Infect ISSN: 1198-743X Impact factor: 8.067