BACKGROUND & AIMS: Rapid onset of resistance to insulin is a prominent component of stress metabolism in multiple trauma patients. Recent studies have clarified the role of amino acids (especially glutamine) in glucose transportation and the benefits of parenteral alanyl-glutamine supplementation (0.3-0.6 g/kg/day) in glucose homeostasis. The aims of this study are to evaluate the incidence of hyperglycemic episodes and the need for exogenous insulin to maintain stable glucose levels in critically ill polytrauma patients supplemented withparenteral glutamine dipeptide (Dipeptiven(®)) versus standard nutritional support. METHODS: This was an open-label randomized-controlled trial of 82 polytrauma patients aged 20-60 years old, randomly assigned into two equal groups independent of sex, age and Injury Severity Score. We excluded patients with diabetes mellitus, or renal or hepatic failure. One group received parenteral Dipeptiven(®) supplementation of 0.5 g/kg/day and the other received standard isocaloric isoproteinic nutritional support. RESULTS: We found that 63% of patients in the glutamine-supplemented group had no hyperglycemic episodes; only 37% required exogenous insulin (mean daily requirement of 44 units/day). In the control group, 51% of patients required insulin (mean daily requirement 63 unit/day; p = 0.0407). CONCLUSIONS: The effect of glutamine supplementation on glucose homeostasis is associated with a lower incidence of hyperglycemia among critically ill polytrauma patients, and leads to a lower mean daily dose of insulin. Controlled-trials.com Identifier: ISRCTN71592366 (http://www.controlled-trials.com/ISRCTN71592366/ISRCTN71592366).
RCT Entities:
BACKGROUND & AIMS: Rapid onset of resistance to insulin is a prominent component of stress metabolism in multiple traumapatients. Recent studies have clarified the role of amino acids (especially glutamine) in glucose transportation and the benefits of parenteral alanyl-glutamine supplementation (0.3-0.6 g/kg/day) in glucose homeostasis. The aims of this study are to evaluate the incidence of hyperglycemic episodes and the need for exogenous insulin to maintain stable glucose levels in critically ill polytraumapatients supplemented with parenteral glutaminedipeptide (Dipeptiven(®)) versus standard nutritional support. METHODS: This was an open-label randomized-controlled trial of 82 polytraumapatients aged 20-60 years old, randomly assigned into two equal groups independent of sex, age and Injury Severity Score. We excluded patients with diabetes mellitus, or renal or hepatic failure. One group received parenteral Dipeptiven(®) supplementation of 0.5 g/kg/day and the other received standard isocaloric isoproteinic nutritional support. RESULTS: We found that 63% of patients in the glutamine-supplemented group had no hyperglycemic episodes; only 37% required exogenous insulin (mean daily requirement of 44 units/day). In the control group, 51% of patients required insulin (mean daily requirement 63 unit/day; p = 0.0407). CONCLUSIONS: The effect of glutamine supplementation on glucose homeostasis is associated with a lower incidence of hyperglycemia among critically ill polytraumapatients, and leads to a lower mean daily dose of insulin. Controlled-trials.com Identifier: ISRCTN71592366 (http://www.controlled-trials.com/ISRCTN71592366/ISRCTN71592366).
Authors: Roland N Dickerson; Vanessa J Kumpf; Allison B Blackmer; Angela L Bingham; Anne M Tucker; Joseph V Ybarra; Michael D Kraft; Todd W Canada Journal: Hosp Pharm Date: 2016-07
Authors: Angelo D'Alessandro; Hunter B Moore; Ernest E Moore; Matthew J Wither; Travis Nemkov; Alexander P Morton; Eduardo Gonzalez; Michael P Chapman; Miguel Fragoso; Anne Slaughter; Angela Sauaia; Christopher C Silliman; Kirk C Hansen; Anirban Banerjee Journal: Shock Date: 2016-08 Impact factor: 3.454