Eun-Jae Chung1, Sang-Hyo Lee1, So-Hye Baek1, Woo-Jin Bae1, Yong-Joon Chang2, Young-Soo Rho3. 1. Department of Otorhinolaryngology-Head and Neck Surgery, Ilsong Memorial Institute of Head and Neck Cancer, Hallym University, College of Medicine, Seoul, Korea. 2. Department of Plastic and Reconstructive Surgery, Ilsong Memorial Institute of Head and Neck Cancer, Hallym University, College of Medicine, Seoul, Korea. 3. Department of Otorhinolaryngology-Head and Neck Surgery, Ewha Womans University, College of Medicine, Seoul, Korea.
Abstract
BACKGROUND: The purpose of this study was to evaluate the outcome and predictive factors for salvage surgery of isolated regional recurrences of head and neck squamous cell carcinoma. METHODS: A retrospective study was conducted with 55 patients who were treated with surgery-based treatment. RESULTS: The 5-year overall survival (OS) and disease-free survival (DFS) rates were 61.8% and 60%, respectively. Extracapsular spread (ECS) was an independent factor associated with worse disease-specific survival. The patients who had advanced N classification, ECS, and in-field recurrence had a significantly worse OS rate, whereas those with an initial DFS time of 6 months or more experienced better outcomes. CONCLUSION: Salvage surgery for isolated regional recurrence resulted in an acceptable oncologic outcome and mortality. Successful surgical salvage is most probable in late recurrence (≥6 months) patients with recurrent N1 stage tumors (no evidence of ECS) outside of the previous treatment field.
BACKGROUND: The purpose of this study was to evaluate the outcome and predictive factors for salvage surgery of isolated regional recurrences of head and neck squamous cell carcinoma. METHODS: A retrospective study was conducted with 55 patients who were treated with surgery-based treatment. RESULTS: The 5-year overall survival (OS) and disease-free survival (DFS) rates were 61.8% and 60%, respectively. Extracapsular spread (ECS) was an independent factor associated with worse disease-specific survival. The patients who had advanced N classification, ECS, and in-field recurrence had a significantly worse OS rate, whereas those with an initial DFS time of 6 months or more experienced better outcomes. CONCLUSION: Salvage surgery for isolated regional recurrence resulted in an acceptable oncologic outcome and mortality. Successful surgical salvage is most probable in late recurrence (≥6 months) patients with recurrent N1 stage tumors (no evidence of ECS) outside of the previous treatment field.
Authors: Teresa Bernadette Steinbichler; L Golm; D Dejaco; D Riedl; B Kofler; C Url; D Wolfram; H Riechelmann Journal: Eur Arch Otorhinolaryngol Date: 2020-01-25 Impact factor: 2.503