BACKGROUND: Binge alcohol drinking is among the most common pattern of alcohol consumption in our society. Binge alcohol consumption has serious negative consequence on mental and physical health. Although alcohol consumption is known to have profound impact on sleep, it is yet unknown as to how binge alcohol affects/alters sleep-wakefulness. The objective of this study was to examine the effect of acute binge alcohol administration on sleep-wakefulness. METHODS: Male Sprague Dawley rats were used in the study. Under standard aseptic surgical conditions, rats (N = 7) were implanted with sleep-recording electrodes. After postoperative recovery and habituation, baseline sleep-wakefulness was recorded. Subsequently, rats were exposed to binge alcohol treatment as follows: One hour before light onset, a priming dose of 5 g/kg of alcohol was administered followed by 2 subsequent doses (adjusted based on the intoxication level of the rat) approximately 8 hours apart. Sleep-wakefulness was continuously recorded for 3 days post-binge. RESULTS: Acute binge alcohol administration had no significant effect on sleep-wakefulness on post-binge Day 1. However, on post-binge Day 2, after blood alcohol concentration (BAC) was 0, sleep disruptions were observed manifested by a reversal of sleep-wakefulness as evident from insomnia-like symptoms (significant increase in wakefulness; significant reduction in nonrapid eye movement [NREM] sleep) during the normal sleep (light) period and excessive sleep (significant increase in NREM sleep) during the normal active (dark) period similar to excessive daytime sleepiness in humans. All sleep-wakefulness changes were normalized on Day 3 post-binge. CONCLUSIONS: Alcohol hangover is defined as the presence of unpleasant symptoms that peak when BAC is 0. Our results suggest that the reversal of sleep-wakefulness accompanies alcohol hangover after binge alcohol administration. Published 2014. This article is a U.S. Government work and is in the public domain in the U.S.A.
BACKGROUND:Binge alcohol drinking is among the most common pattern of alcohol consumption in our society. Binge alcohol consumption has serious negative consequence on mental and physical health. Although alcohol consumption is known to have profound impact on sleep, it is yet unknown as to how binge alcohol affects/alters sleep-wakefulness. The objective of this study was to examine the effect of acute binge alcohol administration on sleep-wakefulness. METHODS: Male Sprague Dawley rats were used in the study. Under standard aseptic surgical conditions, rats (N = 7) were implanted with sleep-recording electrodes. After postoperative recovery and habituation, baseline sleep-wakefulness was recorded. Subsequently, rats were exposed to binge alcohol treatment as follows: One hour before light onset, a priming dose of 5 g/kg of alcohol was administered followed by 2 subsequent doses (adjusted based on the intoxication level of the rat) approximately 8 hours apart. Sleep-wakefulness was continuously recorded for 3 days post-binge. RESULTS: Acute binge alcohol administration had no significant effect on sleep-wakefulness on post-binge Day 1. However, on post-binge Day 2, after blood alcohol concentration (BAC) was 0, sleep disruptions were observed manifested by a reversal of sleep-wakefulness as evident from insomnia-like symptoms (significant increase in wakefulness; significant reduction in nonrapid eye movement [NREM] sleep) during the normal sleep (light) period and excessive sleep (significant increase in NREM sleep) during the normal active (dark) period similar to excessive daytime sleepiness in humans. All sleep-wakefulness changes were normalized on Day 3 post-binge. CONCLUSIONS:Alcohol hangover is defined as the presence of unpleasant symptoms that peak when BAC is 0. Our results suggest that the reversal of sleep-wakefulness accompanies alcohol hangover after binge alcohol administration. Published 2014. This article is a U.S. Government work and is in the public domain in the U.S.A.
Authors: Joris C Verster; Richard Stephens; Renske Penning; Damaris Rohsenow; John McGeary; Dan Levy; Adele McKinney; Frances Finnigan; Thomas M Piasecki; Ana Adan; G David Batty; Lies A L Fliervoet; Thomas Heffernan; Jonathan Howland; Dai-Jin Kim; L Darren Kruisselbrink; Jonathan Ling; Neil McGregor; René J L Murphy; Merel van Nuland; Marieke Oudelaar; Andrew Parkes; Gemma Prat; Nick Reed; Wendy S Slutske; Gordon Smith; Mark Young Journal: Curr Drug Abuse Rev Date: 2010-06
Authors: Fulton T Crews; Michael A Collins; Cynthia Dlugos; John Littleton; Lincoln Wilkins; Edward J Neafsey; Roberta Pentney; Lawrence D Snell; Boris Tabakoff; Jian Zou; Antonio Noronha Journal: Alcohol Clin Exp Res Date: 2004-02 Impact factor: 3.455
Authors: Kevin D Shield; Gerrit Gmel; Tara Kehoe-Chan; Deborah A Dawson; Bridget F Grant; Jürgen Rehm Journal: PLoS One Date: 2013-01-02 Impact factor: 3.240