Literature DB >> 24930834

Halogenated diarylacetylenes repress c-myc expression in cancer cells.

Vitaliy M Sviripa1, Wen Zhang2, Liliia M Kril1, Alice X Liu1, Yaxia Yuan3, Chang-Guo Zhan4, Chunming Liu5, David S Watt6.   

Abstract

Halogenated diarylacetylenes that possess fluorine or chlorine substituents in one aryl ring and N-methylamino or N,N-dimethylamino in the other aryl ring inhibit the proliferation of LS174T colon cancer cells through the repression of c-myc expression and induction of the cyclin-dependent kinase inhibitor-1 (i.e., p21(Wif1/Cip1)) and represent potentially useful antineoplastic agents.
Copyright © 2014 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Antineoplastic agents; Colon cancer; Diarylacetylenes; c-myc

Mesh：

Substances：

Year:  2014        PMID： 24930834      PMCID： PMC4096707          DOI： 10.1016/j.bmcl.2014.04.113

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  7 in total

1.  Changes in S-adenosylmethionine synthetase in human liver cancer: molecular characterization and significance.

Authors:  J Cai; W M Sun; J J Hwang; S C Stain; S C Lu
Journal:  Hepatology       Date:  1996-11       Impact factor: 17.425

2.  Correlation between the expression of methionine adenosyltransferase and the stages of human colorectal carcinoma.

Authors:  K Ito; S Ikeda; N Kojima; M Miura; K Shimizu-Saito; I Yamaguchi; I Katsuyama; K Sanada; T Iwai; H Senoo; S Horikawa
Journal:  Surg Today       Date:  2000       Impact factor: 2.549

3.  Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression.

Authors:  Wen Zhang; Vitaliy Sviripa; Liliia M Kril; Xi Chen; Tianxin Yu; Jiandang Shi; Piotr Rychahou; B Mark Evers; David S Watt; Chunming Liu
Journal:  J Med Chem       Date:  2011-02-03       Impact factor: 7.446

4.  c-Myc and cancer metabolism.

Authors:  Donald M Miller; Shelia D Thomas; Ashraful Islam; David Muench; Kara Sedoris
Journal:  Clin Cancer Res       Date:  2012-10-15       Impact factor: 12.531

5.  Fluorinated N,N-dialkylaminostilbenes repress colon cancer by targeting methionine S-adenosyltransferase 2A.

Authors:  Wen Zhang; Vitaliy Sviripa; Xi Chen; Jiandang Shi; Tianxin Yu; Adel Hamza; Nicholas D Ward; Liliia M Kril; Craig W Vander Kooi; Chang-Guo Zhan; B Mark Evers; David S Watt; Chunming Liu
Journal:  ACS Chem Biol       Date:  2013-02-06       Impact factor: 5.100

6.  Role of methionine adenosyltransferase 2A and S-adenosylmethionine in mitogen-induced growth of human colon cancer cells.

Authors:  Hui Chen; Meng Xia; Mark Lin; Heping Yang; John Kuhlenkamp; Tony Li; Nicole M Sodir; Yong-Heng Chen; Heinz Josef-Lenz; Peter W Laird; Steven Clarke; José M Mato; Shelly C Lu
Journal:  Gastroenterology       Date:  2007-04-11       Impact factor: 22.682

7.  The X protein of hepatitis B virus inhibits apoptosis in hepatoma cells through enhancing the methionine adenosyltransferase 2A gene expression and reducing S-adenosylmethionine production.

Authors:  Quanyan Liu; Jiwei Chen; Li Liu; Jun Zhang; Dongfeng Wang; Lu Ma; Yueming He; Yingle Liu; Zhisu Liu; Jianguo Wu
Journal:  J Biol Chem       Date:  2011-01-19       Impact factor: 5.157
  7 in total
  3 in total

1.  Phenylethynyl-substituted Heterocycles Inhibit Cyclin D1 and Induce the Expression of Cyclin-dependent Kinase Inhibitor p21Wif1/Cip1 in Colorectal Cancer Cells.

Authors:  Vitaliy M Sviripa; Liliia M Kril; Wen Zhang; Yanqi Xie; Przemyslaw Wyrebek; Larissa Ponomareva; Xifu Liu; Yaxia Yuan; Chang-Guo Zhan; David S Watt; Chunming Liu
Journal:  Medchemcomm       Date:  2017-11-03       Impact factor: 3.597

2.  Palladium-catalyzed highly regioselective mono and double Sonogashira cross-coupling reactions of 5-substituted-1,2,3-triiodobenzene under ambient conditions.

Authors:  Raed M Al-Zoubi; Mothana K Al-Omari; Walid K Al-Jammal; Michael J Ferguson
Journal:  RSC Adv       Date:  2020-04-24       Impact factor: 3.361

3.  SIRT3 inhibits prostate cancer by destabilizing oncoprotein c-MYC through regulation of the PI3K/Akt pathway.

Authors:  Yizhou Quan; Naitao Wang; Qianqian Chen; Jin Xu; Wei Cheng; Meijuan Di; Weiliang Xia; Wei-Qiang Gao
Journal:  Oncotarget       Date:  2015-09-22
  3 in total

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