OBJECTIVE: The purpose of this study was to perform clinicopathological evaluations of patients with pure influenza A virus pneumonia. METHODS: We performed clinicopathological analyses of four cases of pure influenza A virus pneumonia. Patients Among the four cases, three were caused by the pandemic (H1N1) 2009 virus. Three patients were analyzed during autopsy, and one underwent transbronchial lung biopsy. RESULTS: We suggest that the interval between influenza virus A pneumonia onset and our analysis affected the pathological findings. Diffuse alveolar damage was observed during the acute phase. After ten days, organizing pneumonia and marked proliferation of premature type II alveolar epithelium were observed. Clinically, intra-alveolar hemorrhage was observed in two patients. Pathologically, hyaline membrane formation and intra-alveolar hemorrhage were observed in all cases. CONCLUSION: Severe epithelial damage was determined as the main mechanism of respiratory failure caused by influenza A virus pneumonia.
OBJECTIVE: The purpose of this study was to perform clinicopathological evaluations of patients with pure influenza A virus pneumonia. METHODS: We performed clinicopathological analyses of four cases of pure influenza A virus pneumonia. Patients Among the four cases, three were caused by the pandemic (H1N1) 2009 virus. Three patients were analyzed during autopsy, and one underwent transbronchial lung biopsy. RESULTS: We suggest that the interval between influenza virus A pneumonia onset and our analysis affected the pathological findings. Diffuse alveolar damage was observed during the acute phase. After ten days, organizing pneumonia and marked proliferation of premature type II alveolar epithelium were observed. Clinically, intra-alveolar hemorrhage was observed in two patients. Pathologically, hyaline membrane formation and intra-alveolar hemorrhage were observed in all cases. CONCLUSION: Severe epithelial damage was determined as the main mechanism of respiratory failure caused by influenza A virus pneumonia.
Authors: S Antoniak; K Tatsumi; Y Hisada; J J Milner; S D Neidich; C M Shaver; R Pawlinski; M A Beck; J A Bastarache; N Mackman Journal: J Thromb Haemost Date: 2016-04-05 Impact factor: 5.824
Authors: Lida P Hariri; Crystal M North; Angela R Shih; Rebecca A Israel; Jason H Maley; Julian A Villalba; Vladimir Vinarsky; Jonah Rubin; Daniel A Okin; Alyssa Sclafani; Jehan W Alladina; Jason W Griffith; Michael A Gillette; Yuval Raz; Christopher J Richards; Alexandra K Wong; Amy Ly; Yin P Hung; Raghu R Chivukula; Camille R Petri; Tiara F Calhoun; Laura N Brenner; Kathryn A Hibbert; Benjamin D Medoff; C Corey Hardin; James R Stone; Mari Mino-Kenudson Journal: Chest Date: 2020-10-07 Impact factor: 9.410
Authors: Qingqing Dai; Ming Ye; Zhiqiang Tang; Kaijiang Yu; Yang Gao; Zhenyu Yang; Junbo Zheng; Shu Zuo; Yan Liu; Fengjie Xie; Qiuyuan Han; Hua He; Hongliang Wang Journal: Ann Transl Med Date: 2021-09