Literature DB >> 24930119

Enabling membrane protein structure and dynamics with X-ray free electron lasers.

Geoffrey K Feld1, Matthias Frank2.   

Abstract

Determining the three-dimensional structures and dynamics of membrane proteins remains one of the great challenges of modern biology. The recent availability of X-ray free electron laser (XFEL) light sources has opened the door to a new and revolutionary approach to performing X-ray analysis of these important biomolecules. Recent advances in sample delivery, data reduction, and phasing have enabled the high-resolution structural probing of membrane proteins at room temperature. While considerable challenges remain, the recent developments described in this review may ultimately provide structural biologists with powerful tools for obtaining unprecedented atomic-scale and dynamic visualization of membrane proteins at near-physiological conditions.
Copyright © 2014 Elsevier Ltd. All rights reserved.

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Year:  2014        PMID： 24930119     DOI： 10.1016/j.sbi.2014.05.002

Source DB:  PubMed          Journal:  Curr Opin Struct Biol        ISSN： 0959-440X            Impact factor:   6.809


  7 in total

Review 1.  New approaches towards the understanding of integral membrane proteins: A structural perspective on G protein-coupled receptors.

Authors:  Reinhard Grisshammer
Journal:  Protein Sci       Date:  2017-06-07       Impact factor: 6.725

2.  Ultrafast isomerization initiated by X-ray core ionization.

Authors:  Chelsea E Liekhus-Schmaltz; Ian Tenney; Timur Osipov; Alvaro Sanchez-Gonzalez; Nora Berrah; Rebecca Boll; Cedric Bomme; Christoph Bostedt; John D Bozek; Sebastian Carron; Ryan Coffee; Julien Devin; Benjamin Erk; Ken R Ferguson; Robert W Field; Lutz Foucar; Leszek J Frasinski; James M Glownia; Markus Gühr; Andrei Kamalov; Jacek Krzywinski; Heng Li; Jonathan P Marangos; Todd J Martinez; Brian K McFarland; Shungo Miyabe; Brendan Murphy; Adi Natan; Daniel Rolles; Artem Rudenko; Marco Siano; Emma R Simpson; Limor Spector; Michele Swiggers; Daniel Walke; Song Wang; Thorsten Weber; Philip H Bucksbaum; Vladimir S Petrovic
Journal:  Nat Commun       Date:  2015-09-10       Impact factor: 14.919

Review 3.  Metalloprotein structures at ambient conditions and in real-time: biological crystallography and spectroscopy using X-ray free electron lasers.

Authors:  Jan Kern; Vittal K Yachandra; Junko Yano
Journal:  Curr Opin Struct Biol       Date:  2015-09-02       Impact factor: 6.809

4.  Determination of crystallographic intensities from sparse data.

Authors:  Kartik Ayyer; Hugh T Philipp; Mark W Tate; Jennifer L Wierman; Veit Elser; Sol M Gruner
Journal:  IUCrJ       Date:  2015-01-01       Impact factor: 4.769

5.  Serial femtosecond crystallography of soluble proteins in lipidic cubic phase.

Authors:  Raimund Fromme; Andrii Ishchenko; Markus Metz; Shatabdi Roy Chowdhury; Shibom Basu; Sébastien Boutet; Petra Fromme; Thomas A White; Anton Barty; John C H Spence; Uwe Weierstall; Wei Liu; Vadim Cherezov
Journal:  IUCrJ       Date:  2015-08-04       Impact factor: 4.769

6.  A high-transparency, micro-patternable chip for X-ray diffraction analysis of microcrystals under native growth conditions.

Authors:  Thomas D Murray; Artem Y Lyubimov; Craig M Ogata; Huy Vo; Monarin Uervirojnangkoorn; Axel T Brunger; James M Berger
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2015-09-26

7.  A fixed-target platform for serial femtosecond crystallography in a hydrated environment.

Authors:  M L Shelby; D Gilbile; T D Grant; C Seuring; B W Segelke; W He; A C Evans; T Pakendorf; P Fischer; M S Hunter; A Batyuk; M Barthelmess; A Meents; M A Coleman; T L Kuhl; M Frank
Journal:  IUCrJ       Date:  2020-01-01       Impact factor: 4.769
  7 in total

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