Sunila Tashfeen1, Nuzhat Salamat2, Saleem Ahmed2. 1. Armed Forces Institute of Pathology, Rawalpindi, Pakistan. Electronic address: sunila.tashfeen@yahoo.com. 2. Armed Forces Institute of Transfusion, Rawalpindi, Pakistan.
Abstract
OBJECTIVE: Find the allele frequencies of Duffy blood group antigens in donor population from northern Pakistan. DESIGN: Cross sectional study. PLACE AND DURATION OF STUDY: Armed Forces Institute of Transfusion (AFIT), Rawalpindi in year 2012. PATIENTS AND METHODS: A total of 1000 healthy, adult blood donors were included in the study. Blood samples were collected in ethylenediamine tetra aceticacid (EDTA) tube and then tested with anti sera Fy(a) and Fy(b) by the tube method. RESULTS: The allele frequencies of Duffy blood group antigens were calculated. The most common phenotype was Fy(a+b+) which was present in 552 (55.2%) donors followed by the Fy(a+b-) phenotype in 228 (22.8%) donors, while 178 (17.8%) were Fy(a-b+) and the least prevalent phenotype was Fy(a-b-) which was present in 42 (4.2%) of donors. CONCLUSION: The majority of our population is heterozygous for Duffy antigens a and b.
OBJECTIVE: Find the allele frequencies of Duffy blood group antigens in donor population from northern Pakistan. DESIGN: Cross sectional study. PLACE AND DURATION OF STUDY: Armed Forces Institute of Transfusion (AFIT), Rawalpindi in year 2012. PATIENTS AND METHODS: A total of 1000 healthy, adult blood donors were included in the study. Blood samples were collected in ethylenediamine tetra aceticacid (EDTA) tube and then tested with anti sera Fy(a) and Fy(b) by the tube method. RESULTS: The allele frequencies of Duffy blood group antigens were calculated. The most common phenotype was Fy(a+b+) which was present in 552 (55.2%) donors followed by the Fy(a+b-) phenotype in 228 (22.8%) donors, while 178 (17.8%) were Fy(a-b+) and the least prevalent phenotype was Fy(a-b-) which was present in 42 (4.2%) of donors. CONCLUSION: The majority of our population is heterozygous for Duffy antigens a and b.
Authors: I Tsintsadze; L AKhvlediani; R Khukhunaishvili; M Koridze; S Tskvitinidze; I NakaShidze; K Dolidze; Rusudan Loria; M Nagervadze Journal: Indian J Hematol Blood Transfus Date: 2019-10-04 Impact factor: 0.900