R J Hassing1, A A van der Eijk2, V Baptista Lopes3, I J Snijdewind4, R A de Man5, S D Pas6, M E van der Ende7. 1. Department of Internal Medicine and Infectious Diseases, Erasmus Medical Center, Rotterdam, The Netherlands; Inspectorate of Health Care, The Hague, The Netherlands. Electronic address: r.hassing@erasmusmc.nl. 2. Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands. Electronic address: a.vandereijk@erasmusmc.nl. 3. Department of Internal Medicine and Infectious Diseases, Erasmus Medical Center, Rotterdam, The Netherlands. Electronic address: VBaptistaLopes@amphia.nl. 4. Department of Internal Medicine and Infectious Diseases, Erasmus Medical Center, Rotterdam, The Netherlands. Electronic address: isnijdewind@gmail.com. 5. Department of Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, The Netherlands. Electronic address: r.deman@erasmusmc.nl. 6. Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands. Electronic address: s.pas@erasmusmc.nl. 7. Department of Internal Medicine and Infectious Diseases, Erasmus Medical Center, Rotterdam, The Netherlands. Electronic address: m.vanderende@erasmusmc.nl.
Abstract
BACKGROUND: In recent years chronic hepatitis E virus (HEV) infections have been reported in immunosuppressed patients, including HIV-positive patients with low CD4 cell counts. Because of delayed anti-HEV seroconversion in patients with CD4 cell count<200 cells/ml it is difficult to draw firm conclusions on HEV-seroprevalence in a population of HIV positive patients. OBJECTIVES: To determine the HEV seroprevalence in a population of HIV infected patients. STUDY DESIGN: We retrospectively analysed the HEV prevalence in a population of 256 HIV infected patients with liver enzyme elevations (LEEs), using HEV specific antibody testing and HEV-RNA detection. RESULTS: Within this cohort we observed a HEV-seroprevalence of 11.7%, without any anti-HEV IgM positive or HEV-RNA positive cases. HEV seropositivity was equally prevalent among different CD4(+) cell count groups. CONCLUSION: Although HIV infected patients in the Netherlands are at risk of acquiring HEV, the number of acute infections is low and no chronic cases were found.
BACKGROUND: In recent years chronic hepatitis E virus (HEV) infections have been reported in immunosuppressed patients, including HIV-positivepatients with low CD4 cell counts. Because of delayed anti-HEV seroconversion in patients with CD4 cell count<200 cells/ml it is difficult to draw firm conclusions on HEV-seroprevalence in a population of HIV positive patients. OBJECTIVES: To determine the HEV seroprevalence in a population of HIV infectedpatients. STUDY DESIGN: We retrospectively analysed the HEV prevalence in a population of 256 HIV infectedpatients with liver enzyme elevations (LEEs), using HEV specific antibody testing and HEV-RNA detection. RESULTS: Within this cohort we observed a HEV-seroprevalence of 11.7%, without any anti-HEV IgM positive or HEV-RNA positive cases. HEV seropositivity was equally prevalent among different CD4(+) cell count groups. CONCLUSION: Although HIV infectedpatients in the Netherlands are at risk of acquiring HEV, the number of acute infections is low and no chronic cases were found.
Authors: Jose D Debes; Suzan D Pas; Zwier M A Groothuismink; Marchina E van der Ende; Robert A de Man; Andre Boonstra Journal: Liver Int Date: 2018-01-19 Impact factor: 5.828
Authors: Mark H Kuniholm; Edgar Ong; Boris M Hogema; Marco Koppelman; Kathryn Anastos; Marion G Peters; Eric C Seaberg; Yue Chen; Kenrad E Nelson; Jeffrey M Linnen Journal: Hepatology Date: 2016-01-16 Impact factor: 17.425
Authors: Ana Maria Passos-Castilho; Anne de Sena; Ana Lucia Coutinho Domingues; Edmundo Pessoa Lopes-Neto; Tibério Batista Medeiros; Celso Francisco Hernandez Granato; Maria Lúcia Ferraz Journal: Braz J Infect Dis Date: 2016-03-26 Impact factor: 3.257