Literature DB >> 24929047

Asterosaponins from the Far Eastern starfish Leptasterias ochotensis and their anticancer activity.

Timofey V Malyarenko1, Alla A Kicha1, Natalia V Ivanchina1, Anatoly I Kalinovsky1, Roman S Popov1, Olesya S Vishchuk1, Valentin A Stonik2.   

Abstract

Six new asterosaponins, leptasteriosides A-F (3-8), one new and one previously known asterogenins (1, 2) were isolated from the alcoholic extract of the Far Eastern starfish Leptasterias ochotensis. The structures of 1-8 were elucidated by extensive NMR and ESI-MS techniques. Compounds 2-8 showed slight or moderate cytotoxic activities against cancer cell lines RPMI-7951 and T-47D. The asterosaponins 3-5 demonstrated a significant inhibition of RPMI-7951 and T-47D cell colony formation in soft agar clonogenic assay in nontoxic doses.
Copyright © 2014 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Asterosaponins; Clonogenic assay; Cytotoxicity; Leptasterias ochotensis; Starfish

Mesh：

Substances：

Year:  2014        PMID： 24929047     DOI： 10.1016/j.steroids.2014.05.027

Source DB:  PubMed          Journal:  Steroids        ISSN： 0039-128X            Impact factor:   2.668


  9 in total

1.  Four New Sulfated Polar Steroids from the Far Eastern Starfish Leptasterias ochotensis: Structures and Activities.

Authors:  Timofey V Malyarenko; Olesya S Malyarenko Vishchuk; Natalia V Ivanchina; Anatoly I Kalinovsky; Roman S Popov; Alla A Kicha
Journal:  Mar Drugs       Date:  2015-07-16       Impact factor: 5.118

2.  The Inhibitory Activity of Luzonicosides from the Starfish Echinaster luzonicus against Human Melanoma Cells.

Authors:  Olesya S Malyarenko; Sergey A Dyshlovoy; Alla A Kicha; Natalia V Ivanchina; Timofey V Malyarenko; Bokemeyer Carsten; von Amsberg Gunhild; Valentin A Stonik; Svetlana P Ermakova
Journal:  Mar Drugs       Date:  2017-07-18       Impact factor: 5.118

3.  Three New Cytotoxic Steroidal Glycosides Isolated from Conus pulicarius Collected in Kosrae, Micronesia.

Authors:  Yeon-Ju Lee; Saem Han; Su Hyun Kim; Hyi-Seung Lee; Hee Jae Shin; Jong Seok Lee; Jihoon Lee
Journal:  Mar Drugs       Date:  2017-12-04       Impact factor: 5.118

4.  Evaluation of the Cytotoxic Effect of the Brittle Star (Ophiocoma Erinaceus) Dichloromethane Extract and Doxorubicin on EL4 Cell Line.

Authors:  Mahbubeh Afzali; Javad Baharara; Khadijeh Nezhad Shahrokhabadi; Elaheh Amini
Journal:  Iran J Pharm Res       Date:  2017       Impact factor: 1.696

Review 5.  The Anticancer Drug Discovery Potential of Marine Invertebrates from Russian Pacific.

Authors:  Vladimir L Katanaev; Salvatore Di Falco; Yuri Khotimchenko
Journal:  Mar Drugs       Date:  2019-08-16       Impact factor: 5.118

Review 6.  Asterosaponins: Structures, Taxonomic Distribution, Biogenesis and Biological Activities.

Authors:  Valentin A Stonik; Alla A Kicha; Timofey V Malyarenko; Natalia V Ivanchina
Journal:  Mar Drugs       Date:  2020-11-24       Impact factor: 5.118

7.  Two New Steroidal Monoglycosides, Anthenosides A₁ and A₂, and Revision of the Structure of Known Anthenoside A with Unusual Monosaccharide Residue from the Starfish Anthenea aspera.

Authors:  Timofey V Malyarenko; Natalia V Ivanchina; Olesya S Malyarenko; Anatoly I Kalinovsky; Pavel S Dmitrenok; Evgeny V Evtushenko; Chau Van Minh; Alla A Kicha
Journal:  Molecules       Date:  2018-05-03       Impact factor: 4.411

8.  In Vitro Anticancer and Proapoptotic Activities of Steroidal Glycosides from the Starfish Anthenea aspera.

Authors:  Timofey V Malyarenko; Olesya S Malyarenko; Alla A Kicha; Natalia V Ivanchina; Anatoly I Kalinovsky; Pavel S Dmitrenok; Svetlana P Ermakova; Valentin A Stonik
Journal:  Mar Drugs       Date:  2018-11-01       Impact factor: 5.118

Review 9.  Bright Spots in The Darkness of Cancer: A Review of Starfishes-Derived Compounds and Their Anti-Tumor Action.

Authors:  Valentina Lazzara; Vincenzo Arizza; Claudio Luparello; Manuela Mauro; Mirella Vazzana
Journal:  Mar Drugs       Date:  2019-10-29       Impact factor: 5.118
  9 in total

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