Literature DB >> 24928907

The KCl-cotransporter KCC2 linked to epilepsy.

Christian A Hübner1.   

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Year:  2014        PMID： 24928907      PMCID： PMC4196972          DOI： 10.15252/embr.201439039

Source DB:  PubMed          Journal:  EMBO Rep        ISSN： 1469-221X            Impact factor:   8.807


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  10 in total

1.  Disruption of KCC2 reveals an essential role of K-Cl cotransport already in early synaptic inhibition.

Authors:  C A Hübner; V Stein; I Hermans-Borgmeyer; T Meyer; K Ballanyi; T J Jentsch
Journal:  Neuron       Date:  2001-05       Impact factor: 17.173

2.  Expression of the KCl cotransporter KCC2 parallels neuronal maturation and the emergence of low intracellular chloride.

Authors:  Valentin Stein; Irm Hermans-Borgmeyer; Thomas J Jentsch; Christian A Hübner
Journal:  J Comp Neurol       Date:  2004-01-01       Impact factor: 3.215

3.  NKCC1-dependent GABAergic excitation drives synaptic network maturation during early hippocampal development.

Authors:  Carsten K Pfeffer; Valentin Stein; Damien J Keating; Hannes Maier; Ilka Rinke; York Rudhard; Moritz Hentschke; Gabriele M Rune; Thomas J Jentsch; Christian A Hübner
Journal:  J Neurosci       Date:  2009-03-18       Impact factor: 6.167

4.  The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation.

Authors:  C Rivera; J Voipio; J A Payne; E Ruusuvuori; H Lahtinen; K Lamsa; U Pirvola; M Saarma; K Kaila
Journal:  Nature       Date:  1999-01-21       Impact factor: 49.962

5.  Genetically encoded impairment of neuronal KCC2 cotransporter function in human idiopathic generalized epilepsy.

Authors:  Kristopher T Kahle; Nancy D Merner; Perrine Friedel; Liliya Silayeva; Bo Liang; Arjun Khanna; Yuze Shang; Pamela Lachance-Touchette; Cynthia Bourassa; Annie Levert; Patrick A Dion; Brian Walcott; Dan Spiegelman; Alexandre Dionne-Laporte; Alan Hodgkinson; Philip Awadalla; Hamid Nikbakht; Jacek Majewski; Patrick Cossette; Tarek Z Deeb; Stephen J Moss; Igor Medina; Guy A Rouleau
Journal:  EMBO Rep       Date:  2014-06-13       Impact factor: 8.807

6.  Exome sequencing of ion channel genes reveals complex profiles confounding personal risk assessment in epilepsy.

Authors:  Tara Klassen; Caleb Davis; Alica Goldman; Dan Burgess; Tim Chen; David Wheeler; John McPherson; Traci Bourquin; Lora Lewis; Donna Villasana; Margaret Morgan; Donna Muzny; Richard Gibbs; Jeffrey Noebels
Journal:  Cell       Date:  2011-06-24       Impact factor: 41.582

7.  Hyperexcitability and epilepsy associated with disruption of the mouse neuronal-specific K-Cl cotransporter gene.

Authors:  Nam-Sik Woo; Jianming Lu; Roger England; Robert McClellan; Samuel Dufour; David B Mount; Ariel Y Deutch; David M Lovinger; Eric Delpire
Journal:  Hippocampus       Date:  2002       Impact factor: 3.899

Review 8.  GABA: a pioneer transmitter that excites immature neurons and generates primitive oscillations.

Authors:  Yehezkel Ben-Ari; Jean-Luc Gaiarsa; Roman Tyzio; Rustem Khazipov
Journal:  Physiol Rev       Date:  2007-10       Impact factor: 37.312

9.  Exome sequencing followed by large-scale genotyping fails to identify single rare variants of large effect in idiopathic generalized epilepsy.

Authors:  Erin L Heinzen; Chantal Depondt; Gianpiero L Cavalleri; Elizabeth K Ruzzo; Nicole M Walley; Anna C Need; Dongliang Ge; Min He; Elizabeth T Cirulli; Qian Zhao; Kenneth D Cronin; Curtis E Gumbs; C Ryan Campbell; Linda K Hong; Jessica M Maia; Kevin V Shianna; Mark McCormack; Rodney A Radtke; Gerard D O'Conner; Mohamad A Mikati; William B Gallentine; Aatif M Husain; Saurabh R Sinha; Krishna Chinthapalli; Ram S Puranam; James O McNamara; Ruth Ottman; Sanjay M Sisodiya; Norman Delanty; David B Goldstein
Journal:  Am J Hum Genet       Date:  2012-08-02       Impact factor: 11.025

10.  A variant of KCC2 from patients with febrile seizures impairs neuronal Cl- extrusion and dendritic spine formation.

Authors:  Martin Puskarjov; Patricia Seja; Sarah E Heron; Tristiana C Williams; Faraz Ahmad; Xenia Iona; Karen L Oliver; Bronwyn E Grinton; Laszlo Vutskits; Ingrid E Scheffer; Steven Petrou; Peter Blaesse; Leanne M Dibbens; Samuel F Berkovic; Kai Kaila
Journal:  EMBO Rep       Date:  2014-03-24       Impact factor: 8.807
  10 in total
  8 in total

Review 1.  Regulation of neuronal chloride homeostasis by neuromodulators.

Authors:  Vivek Mahadevan; Melanie A Woodin
Journal:  J Physiol       Date:  2016-03-31       Impact factor: 5.182

2.  Molecular cloning and biochemical characterization of two cation chloride cotransporter subfamily members of Hydra vulgaris.

Authors:  Anna-Maria Hartmann; Lucie I Pisella; Igor Medina; Hans Gerd Nothwang
Journal:  PLoS One       Date:  2017-06-29       Impact factor: 3.240

3.  Loss of MicroRNA-137 Impairs the Homeostasis of Potassium in Neurons via KCC2.

Authors:  Ting-Wei Mi; Xiao-Wen Sun; Zhi-Meng Wang; Ying-Ying Wang; Xuan-Cheng He; Cong Liu; Shuang-Feng Zhang; Hong-Zhen Du; Chang-Mei Liu; Zhao-Qian Teng
Journal:  Exp Neurobiol       Date:  2020-04-30       Impact factor: 3.261

4.  Disruption of KCC2 in Parvalbumin-Positive Interneurons Is Associated With a Decreased Seizure Threshold and a Progressive Loss of Parvalbumin-Positive Interneurons.

Authors:  Tanja Herrmann; Melanie Gerth; Ralf Dittmann; Daniel Pensold; Martin Ungelenk; Lutz Liebmann; Christian A Hübner
Journal:  Front Mol Neurosci       Date:  2022-02-03       Impact factor: 5.639

5.  Neto2-null mice have impaired GABAergic inhibition and are susceptible to seizures.

Authors:  Vivek Mahadevan; Zahra Dargaei; Evgueni A Ivakine; Anna-Maria Hartmann; David Ng; Jonah Chevrier; Jake Ormond; Hans Gerd Nothwang; Roderick R McInnes; Melanie A Woodin
Journal:  Front Cell Neurosci       Date:  2015-09-23       Impact factor: 5.505

6.  Reduced tonic inhibition after stroke promotes motor performance and epileptic seizures.

Authors:  Nadine Jaenisch; Lutz Liebmann; Madlen Guenther; Christian A Hübner; Christiane Frahm; Otto W Witte
Journal:  Sci Rep       Date:  2016-05-18       Impact factor: 4.379

7.  M-Calpain Activation Facilitates Seizure Induced KCC2 Down Regulation.

Authors:  Li Wan; Liang Ren; Lulan Chen; Guoxiang Wang; Xu Liu; Benjamin H Wang; Yun Wang
Journal:  Front Mol Neurosci       Date:  2018-08-21       Impact factor: 5.639

8.  Mutations in SLC12A5 in epilepsy of infancy with migrating focal seizures.

Authors:  Tommy Stödberg; Amy McTague; Arnaud J Ruiz; Hiromi Hirata; Juan Zhen; Philip Long; Irene Farabella; Esther Meyer; Atsuo Kawahara; Grace Vassallo; Stavros M Stivaros; Magnus K Bjursell; Henrik Stranneheim; Stephanie Tigerschiöld; Bengt Persson; Iftikhar Bangash; Krishna Das; Deborah Hughes; Nicole Lesko; Joakim Lundeberg; Rod C Scott; Annapurna Poduri; Ingrid E Scheffer; Holly Smith; Paul Gissen; Stephanie Schorge; Maarten E A Reith; Maya Topf; Dimitri M Kullmann; Robert J Harvey; Anna Wedell; Manju A Kurian
Journal:  Nat Commun       Date:  2015-09-03       Impact factor: 14.919
  8 in total

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