Linwei Wu1, Ngalei Tam2, Ronghai Deng1, Chenglin Wu1, Philip Chen3, Dongping Wang1, Xiaoshun He4. 1. Department of Organ Transplantation Center of the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China. 2. Department of Organ Transplantation Center of the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China; Hepatobiliary Surgery Department, the University of Hong Kong, Shenzhen Hospital, Shenzhen, Guangdong, China. 3. Nephrology Department, University of Texas, Southwestern Medical Center, Dallas, TX, USA. 4. Department of Organ Transplantation Center of the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China. Electronic address: gdtrcl@163.com.
Abstract
BACKGROUND AND OBJECTIVES: Steroid-resistant acute rejection (SRAR) is an infrequent event under current immunosuppressant but still a risk factor leading to graft loss and patients' death after liver transplantation. There are several strategies for managing this complication according to current literatures, but none of the treatment seems convincing and widely accepted. Here we retrospectively analyzed the clinical data of a cohort of patients to gain an insight into this complication. MATERIALS AND METHODS: A total of 962 adult patients receiving whole liver grafts at a single center between January 2004 and December 2012 were studied. One hundred and forty-two recipients experienced 158 episodes of acute rejection after the operation, 14 recipients had no response to steroid bolus treatment. The clinical data was analyzed retrospectively. RESULTS: Incidence rate of acute rejection after liver transplant in our single center was 14.7% (142/962), among them 8.8% (14/158) were steroid-resistant. These episodes occurred on 19days (6-72days) after the operation, 3 were controlled by anti-T3-receptor antibody (OKT3) treatment, 4 were reversed by IL-2 receptor inhibitors combining with MMF treatment, 2 were reversed by antithymocyte globulin (ATG) treatment. Five did not recover and 2 received retransplantation. Mortality associated with SRAR was 28.6% (4/14, 1 died from acute liver failure, 1 from chronic liver failure, 1 from renal failure after retransplantation and 1 from pulmonary infection after OKT3 treatment). CONCLUSION: SRAR is a severe complication with high mortality after liver transplantation; ATG might serve as a potential treatment.
BACKGROUND AND OBJECTIVES:Steroid-resistant acute rejection (SRAR) is an infrequent event under current immunosuppressant but still a risk factor leading to graft loss and patients' death after liver transplantation. There are several strategies for managing this complication according to current literatures, but none of the treatment seems convincing and widely accepted. Here we retrospectively analyzed the clinical data of a cohort of patients to gain an insight into this complication. MATERIALS AND METHODS: A total of 962 adult patients receiving whole liver grafts at a single center between January 2004 and December 2012 were studied. One hundred and forty-two recipients experienced 158 episodes of acute rejection after the operation, 14 recipients had no response to steroid bolus treatment. The clinical data was analyzed retrospectively. RESULTS: Incidence rate of acute rejection after liver transplant in our single center was 14.7% (142/962), among them 8.8% (14/158) were steroid-resistant. These episodes occurred on 19days (6-72days) after the operation, 3 were controlled by anti-T3-receptor antibody (OKT3) treatment, 4 were reversed by IL-2 receptor inhibitors combining with MMF treatment, 2 were reversed by antithymocyte globulin (ATG) treatment. Five did not recover and 2 received retransplantation. Mortality associated with SRAR was 28.6% (4/14, 1 died from acute liver failure, 1 from chronic liver failure, 1 from renal failure after retransplantation and 1 from pulmonary infection after OKT3 treatment). CONCLUSION: SRAR is a severe complication with high mortality after liver transplantation; ATG might serve as a potential treatment.
Authors: Jae Geun Lee; Juhan Lee; Jung Jun Lee; Seung Hwan Song; Man Ki Ju; Gi Hong Choi; Myoung Soo Kim; Jin Sub Choi; Soon Il Kim; Dong Jin Joo Journal: Medicine (Baltimore) Date: 2016-06 Impact factor: 1.889