Shih-Chi Wu1, Chih-Yuan Fu2, Chih-Hsin Muo3, Yen-Jung Chang4. 1. Trauma and Emergency Center, China Medical University Hospital, Taichung, Taiwan; College of Medicine, China Medical University, Taichung, Taiwan. 2. Department of Trauma and Emergency Surgery, Chang-Gung Memorial Hospital, Linkou, Taiwan. 3. Management Office for Health Data, China Medical University and Hospital, Taichung, Taiwan; College of Medicine, China Medical University, Taichung, Taiwan. 4. Department of Health Promotion and Health Education, National Taiwan Normal University, Taipei, Taiwan. Electronic address: yjchang2012@gmail.com.
Abstract
BACKGROUND: Animal studies indicate that splenocytes may act as precursors of β-islet secretory cells in the pancreas. This study aimed to assess the risk of postoperative type II diabetes after splenectomy in trauma patients. METHODS: We used data from the Taiwan National Health Insurance hospitalized claims. Study 1 included 3,723 patients receiving splenectomy and 3,723 matched patients receiving other types of abdominal surgery. Study 2 included 5,996 patients with spleen injury and 5,996 matched patients with other types of abdominal injury. The hazard ratio for diabetes was estimated using the matched Cox proportional hazard regression model. RESULTS: In trauma patients after surgery, those who received splenectomy had a 2-fold higher risk of diabetes compared with patients without splenectomy after a 3-year follow-up period. In the nonoperative group, there was no difference in diabetes risk between patients with splenic injury and those with other types of injury. CONCLUSIONS: Splenectomy was associated with an increased risk of postoperative type II diabetes in trauma patients. Thus, there may be a role for the spleen in the development of diabetes.
BACKGROUND: Animal studies indicate that splenocytes may act as precursors of β-islet secretory cells in the pancreas. This study aimed to assess the risk of postoperative type II diabetes after splenectomy in traumapatients. METHODS: We used data from the Taiwan National Health Insurance hospitalized claims. Study 1 included 3,723 patients receiving splenectomy and 3,723 matched patients receiving other types of abdominal surgery. Study 2 included 5,996 patients with spleen injury and 5,996 matched patients with other types of abdominal injury. The hazard ratio for diabetes was estimated using the matched Cox proportional hazard regression model. RESULTS: In traumapatients after surgery, those who received splenectomy had a 2-fold higher risk of diabetes compared with patients without splenectomy after a 3-year follow-up period. In the nonoperative group, there was no difference in diabetes risk between patients with splenic injury and those with other types of injury. CONCLUSIONS: Splenectomy was associated with an increased risk of postoperative type II diabetes in traumapatients. Thus, there may be a role for the spleen in the development of diabetes.
Authors: Menghua Dai; Cheng Xing; Ning Shi; Shunda Wang; Guangdong Wu; Quan Liao; Taiping Zhang; Ge Chen; Wenming Wu; Junchao Guo; Ziwen Liu Journal: BMJ Open Diabetes Res Care Date: 2020-10