Laurie M Baker1, David H Laidlaw2, Thomas E Conturo2, Joseph Hogan2, Yi Zhao2, Xi Luo2, Stephen Correia2, Ryan Cabeen2, Elizabeth M Lane2, Jodi M Heaps2, Jacob Bolzenius2, Lauren E Salminen2, Erbil Akbudak2, Amanda R McMichael2, Christina Usher2, Ashley Behrman2, Robert H Paul2. 1. From the University of Missouri-St. Louis (L.M.B., J.M.H., J.B., L.E.S., C.U., A.B., R.H.P.); Computer Science Department (D.H.L., R.C.) and Department for Biostatistics and Center for Statistical Sciences (J.H., Y.Z., X.L.), Brown University, Providence, RI; Washington University School of Medicine (T.E.C., E.A., A.R.M.), Mallinckrodt Institute of Radiology, St. Louis, MO; Division of Biology and Medicine (S.C.), Brown Medical School, Providence, RI; and Vanderbilt University Medical Center (E.M.L.), Nashville, TN. lauriebaker@umsl.edu. 2. From the University of Missouri-St. Louis (L.M.B., J.M.H., J.B., L.E.S., C.U., A.B., R.H.P.); Computer Science Department (D.H.L., R.C.) and Department for Biostatistics and Center for Statistical Sciences (J.H., Y.Z., X.L.), Brown University, Providence, RI; Washington University School of Medicine (T.E.C., E.A., A.R.M.), Mallinckrodt Institute of Radiology, St. Louis, MO; Division of Biology and Medicine (S.C.), Brown Medical School, Providence, RI; and Vanderbilt University Medical Center (E.M.L.), Nashville, TN.
Abstract
OBJECTIVE: To investigate the relationship between older age and mean cerebral white matter fiber bundle lengths (FBLs) in specific white matter tracts in the brain using quantified diffusion MRI. METHODS: Sixty-three healthy adults older than 50 years underwent diffusion tensor imaging. Tractography tracings of cerebral white matter fiber bundles were derived from the diffusion tensor imaging data. RESULTS: Results revealed significantly shorter FBLs in the anterior thalamic radiation for every 1-year increase over the age of 50 years. CONCLUSIONS: We investigated the effects of age on FBL in specific white matter tracts in the brains of healthy older individuals utilizing quantified diffusion MRI. The results revealed a significant inverse relationship between age and FBL. Longitudinal studies of FBL across a lifespan are needed to examine the specific changes to the integrity of white matter.
OBJECTIVE: To investigate the relationship between older age and mean cerebral white matter fiber bundle lengths (FBLs) in specific white matter tracts in the brain using quantified diffusion MRI. METHODS: Sixty-three healthy adults older than 50 years underwent diffusion tensor imaging. Tractography tracings of cerebral white matter fiber bundles were derived from the diffusion tensor imaging data. RESULTS: Results revealed significantly shorter FBLs in the anterior thalamic radiation for every 1-year increase over the age of 50 years. CONCLUSIONS: We investigated the effects of age on FBL in specific white matter tracts in the brains of healthy older individuals utilizing quantified diffusion MRI. The results revealed a significant inverse relationship between age and FBL. Longitudinal studies of FBL across a lifespan are needed to examine the specific changes to the integrity of white matter.
Authors: Setsu Wakana; Hangyi Jiang; Lidia M Nagae-Poetscher; Peter C M van Zijl; Susumu Mori Journal: Radiology Date: 2003-11-26 Impact factor: 11.105
Authors: Paola M Garcia-Egan; Rebecca N Preston-Campbell; Lauren E Salminen; Jodi M Heaps-Woodruff; Lila Balla; Ryan P Cabeen; David H Laidlaw; Thomas E Conturo; Robert H Paul Journal: Brain Imaging Behav Date: 2019-12 Impact factor: 3.978
Authors: Laurie M Baker; David H Laidlaw; Ryan Cabeen; Erbil Akbudak; Thomas E Conturo; Stephen Correia; David F Tate; Jodi M Heaps-Woodruff; Matthew R Brier; Jacob Bolzenius; Lauren E Salminen; Elizabeth M Lane; Amanda R McMichael; Robert H Paul Journal: Brain Imaging Behav Date: 2017-06 Impact factor: 3.978
Authors: Ashley M Behrman-Lay; Christina Usher; Thomas E Conturo; Stephen Correia; David H Laidlaw; Elizabeth M Lane; Jacob Bolzenius; Jodi M Heaps; Lauren E Salminen; Laurie M Baker; Ryan Cabeen; Erbil Akbudak; Xi Luo; Peisi Yan; Robert H Paul Journal: Brain Imaging Behav Date: 2015-12 Impact factor: 3.978
Authors: Lauren E Salminen; Peter R Schofield; Kerrie D Pierce; Steven E Bruce; Michael G Griffin; David F Tate; Ryan P Cabeen; David H Laidlaw; Thomas E Conturo; Jacob D Bolzenius; Robert H Paul Journal: Behav Brain Res Date: 2017-04-27 Impact factor: 3.332
Authors: Jodi M Heaps-Woodruff; John Joska; Ryan Cabeen; Laurie M Baker; Lauren E Salminen; Jacqueline Hoare; David H Laidlaw; Rachel Wamser-Nanney; Chun-Zi Peng; Susan Engelbrecht; Soraya Seedat; Dan J Stein; Robert H Paul Journal: Brain Imaging Behav Date: 2018-10 Impact factor: 3.978
Authors: Adrian Tsang; Catherine A Lebel; Signe L Bray; Bradley G Goodyear; Moiz Hafeez; Roberto C Sotero; Cheryl R McCreary; Richard Frayne Journal: Front Aging Neurosci Date: 2017-05-18 Impact factor: 5.750