Literature DB >> 24928033

Varicella zoster virus DNA does not accumulate in infected human neurons.

Nicholas L Baird1, Jacqueline L Bowlin1, Xiaoli Yu1, Stipan Jonjić2, Jürgen Haas3, Randall J Cohrs4, Don Gilden5.   

Abstract

Varicella zoster virus (VZV) is an exclusively human neurotropic alphaherpesvirus. It is unclear why human neurons infected in vitro with VZV at low multiplicity of infection do not exhibit a cytopathic effect (CPE) even though all VZV genes are transcribed, VZV proteins from all kinetic classes are translated and minimal infectious virus is produced. Here, we show that the lack of VZV-induced CPE correlates with the low abundance of viral DNA.
Copyright © 2014 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Human neurons; Tissue culture; VZV DNA

Mesh：

Substances：

Year:  2014        PMID： 24928033      PMCID： PMC4108071          DOI： 10.1016/j.virol.2014.04.014

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  11 in total

1.  Aberrant virion assembly and limited glycoprotein C production in varicella-zoster virus-infected neurons.

Authors:  Charles Grose; Xiaoli Yu; Randall J Cohrs; John E Carpenter; Jacqueline L Bowlin; Don Gilden
Journal:  J Virol       Date:  2013-06-26       Impact factor: 5.103

2.  Synthesis and decay of varicella zoster virus transcripts.

Authors:  Yevgeniy Azarkh; Lars Dölken; Maria Nagel; Don Gilden; Randall J Cohrs
Journal:  J Neurovirol       Date:  2011-04-12       Impact factor: 2.643

Review 3.  Review: The neurobiology of varicella zoster virus infection.

Authors:  D Gilden; R Mahalingam; M A Nagel; S Pugazhenthi; R J Cohrs
Journal:  Neuropathol Appl Neurobiol       Date:  2011-08       Impact factor: 8.090

4.  Differential susceptibility of human neural cell types in culture to infection with herpes simplex virus.

Authors:  P G Kennedy; G B Clements; S M Brown
Journal:  Brain       Date:  1983-03       Impact factor: 13.501

5.  Varicella-zoster virus (VZV) infection of neurons derived from human embryonic stem cells: direct demonstration of axonal infection, transport of VZV, and productive neuronal infection.

Authors:  Amos Markus; Sergei Grigoryan; Anna Sloutskin; Michael B Yee; Hua Zhu; In Hong Yang; Nitish V Thakor; Ronit Sarid; Paul R Kinchington; Ronald S Goldstein
Journal:  J Virol       Date:  2011-04-27       Impact factor: 5.103

6.  Varicella-zoster virus infection of differentiated human neural stem cells.

Authors:  Subbiah Pugazhenthi; Sreekala Nair; Kalpana Velmurugan; Qiaoling Liang; Ravi Mahalingam; Randall J Cohrs; Maria A Nagel; Don Gilden
Journal:  J Virol       Date:  2011-04-27       Impact factor: 5.103

7.  A self-excisable infectious bacterial artificial chromosome clone of varicella-zoster virus allows analysis of the essential tegument protein encoded by ORF9.

Authors:  B Karsten Tischer; Benedikt B Kaufer; Marvin Sommer; Felix Wussow; Ann M Arvin; Nikolaus Osterrieder
Journal:  J Virol       Date:  2007-10-03       Impact factor: 5.103

8.  Productive vs non-productive infection by cell-free varicella zoster virus of human neurons derived from embryonic stem cells is dependent upon infectious viral dose.

Authors:  Anna Sloutskin; Paul R Kinchington; Ronald S Goldstein
Journal:  Virology       Date:  2013-06-12       Impact factor: 3.616

9.  Complications of varicella zoster virus reactivation.

Authors:  Maria A Nagel; Don Gilden
Journal:  Curr Treat Options Neurol       Date:  2013-08       Impact factor: 3.972

10.  Varicella zoster virus infection of highly pure terminally differentiated human neurons.

Authors:  Xiaoli Yu; Scott Seitz; Tiffany Pointon; Jacqueline L Bowlin; Randall J Cohrs; Stipan Jonjić; Jürgen Haas; Mary Wellish; Don Gilden
Journal:  J Neurovirol       Date:  2012-12-12       Impact factor: 3.739
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  17 in total

1.  Simian Varicella Virus Is Present in Macrophages, Dendritic Cells, and T Cells in Lymph Nodes of Rhesus Macaques after Experimental Reactivation.

Authors:  Vicki Traina-Dorge; Lara A Doyle-Meyers; Robert Sanford; Jennifer Manfredo; Anna Blackmon; Mary Wellish; Stephanie James; Xavier Alvarez; Cecily Midkiff; Brent E Palmer; Eileen Deharo; Don Gilden; Ravi Mahalingam
Journal:  J Virol       Date:  2015-07-15       Impact factor: 5.103

2.  Interferon Gamma Prolongs Survival of Varicella-Zoster Virus-Infected Human Neurons In Vitro.

Authors:  Nicholas L Baird; Jacqueline L Bowlin; Taylor J Hotz; Randall J Cohrs; Don Gilden
Journal:  J Virol       Date:  2015-05-06       Impact factor: 5.103

3.  Human Embryonic Stem Cell-Derived Neurons Are Highly Permissive for Varicella-Zoster Virus Lytic Infection.

Authors:  Tomohiko Sadaoka; Cindi L Schwartz; Labchan Rajbhandari; Arun Venkatesan; Jeffrey I Cohen
Journal:  J Virol       Date:  2017-12-14       Impact factor: 5.103

4.  Interleukin-6 and type 1 interferons inhibit varicella zoster virus replication in human neurons.

Authors:  Christina N Como; Catherine M Pearce; Randall J Cohrs; Nicholas L Baird
Journal:  Virology       Date:  2018-07-04       Impact factor: 3.616

5.  Prevalence and distribution of VZV in temporal arteries of patients with giant cell arteritis.

Authors:  Don Gilden; Teresa White; Nelly Khmeleva; Anna Heintzman; Alexander Choe; Philip J Boyer; Charles Grose; John E Carpenter; April Rempel; Nathan Bos; Balasubramaniyam Kandasamy; Kelly Lear-Kaul; Dawn B Holmes; Jeffrey L Bennett; Randall J Cohrs; Ravi Mahalingam; Naresh Mandava; Charles G Eberhart; Brian Bockelman; Robert J Poppiti; Madhura A Tamhankar; Franz Fogt; Malena Amato; Edward Wood; Vikram Durairaj; Steve Rasmussen; Vigdis Petursdottir; Lea Pollak; Sonia Mendlovic; Denis Chatelain; Kathy Keyvani; Wolfgang Brueck; Maria A Nagel
Journal:  Neurology       Date:  2015-02-18       Impact factor: 9.910

6.  Varicella Zoster Virus in Temporal Arteries of Patients With Giant Cell Arteritis.

Authors:  Don Gilden; Maria Nagel
Journal:  J Infect Dis       Date:  2015-07-15       Impact factor: 5.226

Review 7.  A comparison of herpes simplex virus type 1 and varicella-zoster virus latency and reactivation.

Authors:  Peter G E Kennedy; Joel Rovnak; Hussain Badani; Randall J Cohrs
Journal:  J Gen Virol       Date:  2015-03-20       Impact factor: 3.891

8.  Targeted Genome Sequencing Reveals Varicella-Zoster Virus Open Reading Frame 12 Deletion.

Authors:  Randall J Cohrs; Katherine S Lee; Addilynn Beach; Bridget Sanford; Nicholas L Baird; Christina Como; Chiharu Graybill; Dallas Jones; Eden Tekeste; Mitchell Ballard; Xiaomi Chen; David Yalacki; Seth Frietze; Kenneth Jones; Tihana Lenac Rovis; Stipan Jonjić; Jürgen Haas; Don Gilden
Journal:  J Virol       Date:  2017-09-27       Impact factor: 5.103

9.  Inhibition of phosphorylated-STAT1 nuclear translocation and antiviral protein expression in human brain vascular adventitial fibroblasts infected with varicella-zoster virus.

Authors:  Maria A Nagel; Stephanie F James; Igor Traktinskiy; Ann Wyborny; Alexander Choe; April Rempel; Nicholas L Baird; Don Gilden
Journal:  J Virol       Date:  2014-07-23       Impact factor: 5.103

10.  Varicella Zoster Virus Infection in Granulomatous Arteritis of the Aorta.

Authors:  Don Gilden; Teresa White; Philip J Boyer; Kristin M Galetta; E Tessa Hedley-Whyte; Meredith Frank; Dawn Holmes; Maria A Nagel
Journal:  J Infect Dis       Date:  2016-03-31       Impact factor: 5.226
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