| Literature DB >> 24927697 |
Zheng Ruan1, Yuhui Yang, Yan Zhou, Yanmei Wen, Sheng Ding, Gang Liu, Xin Wu, Peng Liao, Zeyuan Deng, Houssein Assaad, Guoyao Wu, Yulong Yin.
Abstract
This study was conducted to investigate effects of chlorogenic acid (CGA) supplementation on serum and hepatic metabolomes in rats. Rats received daily intragastric administration of either CGA (60 mg/kg body weight) or distilled water (control) for 4 weeks. Growth performance, serum biochemical profiles, and hepatic morphology were measured. Additionally, serum and liver tissue extracts were analyzed for metabolomes by high-resolution (1)H nuclear magnetic resonance-based metabolomics and multivariate statistics. CGA did not affect rat growth performance, serum biochemical profiles, or hepatic morphology. However, supplementation with CGA decreased serum concentrations of lactate, pyruvate, succinate, citrate, β-hydroxybutyrate and acetoacetate, while increasing serum concentrations of glycine and hepatic concentrations of glutathione. These results suggest that CGA supplementation results in perturbation of energy and amino acid metabolism in rats. We suggest that glycine and glutathione in serum may be useful biomarkers for biological properties of CGA on nitrogen metabolism in vivo.Entities:
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Year: 2014 PMID： 24927697 PMCID： PMC5013734 DOI： 10.1007/s00726-014-1762-7
Source DB: PubMed Journal: Amino Acids ISSN： 0939-4451 Impact factor: 3.520