Literature DB >> 24927192

Non-invasive prenatal testing: ethics and policy considerations.

Meredith Vanstone1, Carol King2, Barbra de Vrijer2, Jeff Nisker3.   

Abstract

New technologies analyzing fetal DNA in maternal blood have led to the wide commercial availability of non-invasive prenatal testing (NIPT). We present here for clinicians the ethical and policy issues related to an emerging practice option. Although NIPT presents opportunities for pregnant women, particularly women who are at increased risk of having a baby with an abnormality or who are otherwise likely to access invasive prenatal testing, NIPT brings significant ethics and policy challenges. The ethical issues include multiple aspects of informed decision-making, such as access to counselling about the possible results of the test in advance of making a decision about participation in NIPT. Policy considerations include issues related to offering and promoting a privately available medical strategy in publicly funded institutions. Ethics and policy considerations merge in NIPT with regard to sex selection and support for persons living with disabilities.

Entities:  

Keywords:  cell free fetal DNA; ethics; non-invasive prenatal testing; policy; prenatal diagnosis; prenatal screening

Mesh:

Substances:

Year:  2014        PMID: 24927192     DOI: 10.1016/S1701-2163(15)30568-5

Source DB:  PubMed          Journal:  J Obstet Gynaecol Can        ISSN: 1701-2163


  13 in total

1.  Non-invasive Prenatal Testing (NIPT): Better Meet an Expert!: The Case of a Late Detected Trisomy 13 Reveals Structural Problems in NIPT Counselling and Highlights Substantial Risks for the Reproductive Autonomy.

Authors:  T Ohnhaeuser; D Schmitz
Journal:  Geburtshilfe Frauenheilkd       Date:  2016-03       Impact factor: 2.915

2.  Non-invasive prenatal testing (NIPT) and pregnant women's views on good motherhood: a qualitative study.

Authors:  Elisa Garcia; Lidewij Henneman; Janneke T Gitsels-van der Wal; Linda Martin; Isabel Koopmanschap; Mireille N Bekker; Danielle R M Timmermans
Journal:  Eur J Hum Genet       Date:  2021-08-17       Impact factor: 5.351

3.  "I think we've got too many tests!": Prenatal providers' reflections on ethical and clinical challenges in the practice integration of cell-free DNA screening.

Authors:  B L Gammon; S A Kraft; M Michie; M Allyse
Journal:  Ethics Med Public Health       Date:  2016 Jul-Sep

4.  Non-invasive prenatal testing for aneuploidy and beyond: challenges of responsible innovation in prenatal screening.

Authors:  Wybo Dondorp; Guido de Wert; Yvonne Bombard; Diana W Bianchi; Carsten Bergmann; Pascal Borry; Lyn S Chitty; Florence Fellmann; Francesca Forzano; Alison Hall; Lidewij Henneman; Heidi C Howard; Anneke Lucassen; Kelly Ormond; Borut Peterlin; Dragica Radojkovic; Wolf Rogowski; Maria Soller; Aad Tibben; Lisbeth Tranebjærg; Carla G van El; Martina C Cornel
Journal:  Eur J Hum Genet       Date:  2015-03-18       Impact factor: 4.246

Review 5.  Non-invasive prenatal testing for fetal chromosome abnormalities: review of clinical and ethical issues.

Authors:  Jean Gekas; Sylvie Langlois; Vardit Ravitsky; François Audibert; David Gradus van den Berg; Hazar Haidar; François Rousseau
Journal:  Appl Clin Genet       Date:  2016-02-04

6.  What do people want to know about NIPT? Content analysis of questions emailed to national NIPT information websites.

Authors:  Saskia Tamminga; Laura van Dussen; E J Joanne Verweij; Marjon A de Boer; Martina C Cornel; Lidewij Henneman
Journal:  Prenat Diagn       Date:  2017-02-28       Impact factor: 3.050

7.  Knowledge and Attitudes Regarding Non-Invasive Prenatal Testing (NIPT) and Preferences for Risk Information among High School Students in Sweden.

Authors:  Susanne Georgsson; Ellika Sahlin; Moa Iwarsson; Magnus Nordenskjöld; Peter Gustavsson; Erik Iwarsson
Journal:  J Genet Couns       Date:  2016-08-02       Impact factor: 2.537

8.  Women's perspectives on the ethical implications of non-invasive prenatal testing: a qualitative analysis to inform health policy decisions.

Authors:  Meredith Vanstone; Alexandra Cernat; Jeff Nisker; Lisa Schwartz
Journal:  BMC Med Ethics       Date:  2018-04-16       Impact factor: 2.652

9.  Offering non-invasive prenatal testing as part of routine clinical service. Can high levels of informed choice be maintained?

Authors:  Celine Lewis; Melissa Hill; Lyn S Chitty
Journal:  Prenat Diagn       Date:  2017-10-17       Impact factor: 3.050

10.  Limits to the scope of non-invasive prenatal testing (NIPT): an analysis of the international ethical framework for prenatal screening and an interview study with Dutch professionals.

Authors:  A Kater-Kuipers; E M Bunnik; I D de Beaufort; R J H Galjaard
Journal:  BMC Pregnancy Childbirth       Date:  2018-10-19       Impact factor: 3.007

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