Christiane Gocke1, Birte Holtfreter1, Peter Meisel1, Anne Grotevendt2, Lukasz Jablonowski1, Matthias Nauck2, Marcello Ricardo Paulista Markus3, Thomas Kocher4. 1. Unit of Periodontology, Department of Restorative Dentistry, Periodontology, and Endodontology, University Medicine Greifswald, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany. 2. Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany. 3. Department Study of Health in Pomerania/Clinical-Epidemiological Research, Institute for Community Medicine, University Medicine Greifswald, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany. 4. Unit of Periodontology, Department of Restorative Dentistry, Periodontology, and Endodontology, University Medicine Greifswald, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany. Electronic address: kocher@uni-greifswald.de.
Abstract
OBJECTIVE: Periodontitis is considered to promote atherosclerosis and cardiovascular diseases through increased low-grade systemic inflammation. However, there is no information on the long-term impact of periodontitis on systemic inflammation from cohort studies. Thus, this study aims to assess the impact of periodontitis on systemic inflammation (fibrinogen and white blood cells (WBC)) in a population-based longitudinal survey in north-eastern Germany. METHODS: The study sample comprised 2622 subjects from the Study of Health in Pomerania with complete 5- and 11-year follow-ups. Periodontitis was assessed by probing depth and clinical attachment level. Multilevel regression analyses were applied to evaluate associations between periodontitis measures and i) fibrinogen/WBC count using 11-year follow-up data and ii) respective z-scores of fibrinogen/WBC count using 5- and 11-year follow-up data. We adjusted for common cardiovascular risk factors and stratified analyses by abdominal obesity (P for interaction <0.10). RESULTS: In lean subjects, beta-coefficients of mean probing depth were B = 0.13 (0.08-0.019; P < 0.001) for fibrinogen and B = 0.50 (0.37-0.64; P < 0.001) for WBC count using 11-year follow-up data only. For lean subjects, models using z-scores confirmed that increased mean probing depths were associated with increased fibrinogen z-scores (B = 0.14 (0.09-0.18; P < 0.001)) and increased WBC z-scores (B = 0.16 (0.11-0.20; P < 0.001)). Consistent results were found for mean clinical attachment levels. For abdominally obese subjects, relations between periodontitis measures and levels of inflammation markers were less pronounced or non-significant. CONCLUSION: Modified by abdominal obesity, periodontitis affected systemic inflammation in a significant dose-dependent manner. Results contribute to the discussion on how periodontitis is linked to atherosclerosis and cardiovascular diseases.
OBJECTIVE:Periodontitis is considered to promote atherosclerosis and cardiovascular diseases through increased low-grade systemic inflammation. However, there is no information on the long-term impact of periodontitis on systemic inflammation from cohort studies. Thus, this study aims to assess the impact of periodontitis on systemic inflammation (fibrinogen and white blood cells (WBC)) in a population-based longitudinal survey in north-eastern Germany. METHODS: The study sample comprised 2622 subjects from the Study of Health in Pomerania with complete 5- and 11-year follow-ups. Periodontitis was assessed by probing depth and clinical attachment level. Multilevel regression analyses were applied to evaluate associations between periodontitis measures and i) fibrinogen/WBC count using 11-year follow-up data and ii) respective z-scores of fibrinogen/WBC count using 5- and 11-year follow-up data. We adjusted for common cardiovascular risk factors and stratified analyses by abdominal obesity (P for interaction <0.10). RESULTS: In lean subjects, beta-coefficients of mean probing depth were B = 0.13 (0.08-0.019; P < 0.001) for fibrinogen and B = 0.50 (0.37-0.64; P < 0.001) for WBC count using 11-year follow-up data only. For lean subjects, models using z-scores confirmed that increased mean probing depths were associated with increased fibrinogen z-scores (B = 0.14 (0.09-0.18; P < 0.001)) and increased WBC z-scores (B = 0.16 (0.11-0.20; P < 0.001)). Consistent results were found for mean clinical attachment levels. For abdominally obese subjects, relations between periodontitis measures and levels of inflammation markers were less pronounced or non-significant. CONCLUSION: Modified by abdominal obesity, periodontitis affected systemic inflammation in a significant dose-dependent manner. Results contribute to the discussion on how periodontitis is linked to atherosclerosis and cardiovascular diseases.
Authors: A A Akinkugbe; C L Avery; A S Barritt; S R Cole; M Lerch; J Mayerle; S Offenbacher; A Petersmann; M Nauck; H Völzke; G D Slade; G Heiss; T Kocher; B Holtfreter Journal: J Dent Res Date: 2017-07-21 Impact factor: 6.116
Authors: Ahmed A Alhassani; Frank B Hu; Bernard A Rosner; Fred K Tabung; Walter C Willett; Kaumudi J Joshipura Journal: Br J Nutr Date: 2021-01-08 Impact factor: 3.718
Authors: Mark Moeller; Christiane Pink; Nicole Endlich; Karlhans Endlich; Hans-Jörgen Grabe; Henry Völzke; Marcus Dörr; Matthias Nauck; Markus M Lerch; Rüdiger Köhling; Birte Holtfreter; Thomas Kocher; Georg Fuellen Journal: PLoS One Date: 2017-04-19 Impact factor: 3.240
Authors: Angela Pia Cazzolla; Michele Di Cosola; Andrea Ballini; Luigi Santacroce; Roberto Lovero; Nunzio Francesco Testa; Vitantonio Lacarbonara; Annarosa De Franco; Giuseppe Troiano; Stefania Cantore; Mariasevera Di Comite; Riccardo Nocini; Lorenzo Lo Muzio; Vito Crincoli; Mario Dioguardi Journal: Biomed Res Int Date: 2021-10-29 Impact factor: 3.411
Authors: Tasha M Santiago-Rodriguez; Mayuri Naidu; Shira R Abeles; Tobias K Boehm; Melissa Ly; David T Pride Journal: BMC Genomics Date: 2015-07-28 Impact factor: 3.969
Authors: Eileen Moritz; Gabriele Jedlitschky; Bernhard H Rauch; Birte Holtfreter; Josefine Negnal; Mladen V Tzvetkov; Günter Daum; Marcus Dörr; Stephan B Felix; Henry Völzke; Matthias Nauck; Edzard Schwedhelm; Peter Meisel; Thomas Kocher Journal: J Inflamm Res Date: 2021-06-30