Jaime H Noguez 1 , Corinne R Fantz 2 Show Affiliations »
Abstract
OBJECTIVES: To provide clarity on the pros and cons of using prostate-specific antigen (PSA) as a screening tool for prostate cancer. METHODS: Case scenarios and a literature review of recently published clinical trial data are presented to provide evidence of the controversy. RESULTS: PSA is a sensitive biomarker for detecting diseases of the prostate, but it is limited in its ability to distinguish cancerous from noncancerous conditions or aggressive from indolent cancers and has resulted in a considerable amount of overdiagnosis and overtreatment. CONCLUSIONS: The analytical methodology for total PSA testing is both reliable and cost-effective, but patients should be encouraged to talk to their providers to understand the benefits and harms associated with this testing. Copyright© by the American Society for Clinical Pathology.
OBJECTIVES: To provide clarity on the pros and cons of using prostate-specific antigen (PSA) as a screening tool for prostate cancer . METHODS: Case scenarios and a literature review of recently published clinical trial data are presented to provide evidence of the controversy. RESULTS: PSA is a sensitive biomarker for detecting diseases of the prostate, but it is limited in its ability to distinguish cancerous from noncancerous conditions or aggressive from indolent cancers and has resulted in a considerable amount of overdiagnosis and overtreatment. CONCLUSIONS: The analytical methodology for total PSA testing is both reliable and cost-effective, but patients should be encouraged to talk to their providers to understand the benefits and harms associated with this testing. Copyright© by the American Society for Clinical Pathology.
Entities: Disease
Gene
Species
Keywords:
Prostate cancer; Prostate-specific antigen; Screening
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Year: 2014
PMID： 24926079 DOI： 10.1309/AJCPU6OOKL9JHEUR
Source DB: PubMed Journal: Am J Clin Pathol ISSN： 0002-9173 Impact factor: 2.493