J Liu1, L L Sun1, L P He2, W H Ling1, Z M Liu3, Y M Chen4. 1. Guangdong Provincial Key Laboratory of Food, Nutrition, and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, Guangdong, People's Republic of China. 2. Guangdong Provincial Key Laboratory of Food, Nutrition, and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, Guangdong, People's Republic of China; Guangzhou Panyu Central Hospital, People's Republic of China. 3. Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong Special Administrative Region. 4. Guangdong Provincial Key Laboratory of Food, Nutrition, and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, Guangdong, People's Republic of China. Electronic address: chenyum@mail.sysu.edu.cn.
Abstract
BACKGROUND AND AIM: The associations between soy food consumption, cardiometabolic disturbances and subclinical atherosclerosis remain controversial due to limited evidence. We examined the associations of habitual soy food consumption with cardiometabolic disturbances and carotid intima-media thickness (CIMT). METHODS AND RESULTS: We included 2939 subjects (2135 women and 804 men) aged 50-75 years in this community-based cross-sectional study. Dietary data and other covariates were collected using interviewer-administered questionnaires. We determined CIMT in relation to each subject's common carotid artery, internal carotid artery, carotid bifurcation, blood lipids, glucose and urine acid, blood pressure and waist circumference. A logistic regression model was applied to estimate the odd ratios (ORs) and 95% confidence intervals (CIs), and linear regression was used to estimate the regression coefficient and 95% CIs. After adjusting for potential confounders, we found that greater consumption of soy protein (6.1 vs. 0.5 g/d) was inverse associated with the presence of elevated total cholesterol (TC), dyslipidemia, abdominal obesity and hyperuricemia in women, and with abdominal obesity in men, although no significant sex-soy interactions were observed (P: 0.145-0.985). The consumption of soy protein and isoflavones was inversely associated with the number of cardiometabolic disturbances among women, but not men. There were no significant associations of soy protein and isoflavones with CIMT thickening and other cardiometabolic disturbances. CONCLUSION: Greater soy consumption was associated with a lower presence of elevated TC, dyslipidemia, hyperuricemia and less number of cardiometabolic disturbances components in women.
BACKGROUND AND AIM: The associations between soy food consumption, cardiometabolic disturbances and subclinical atherosclerosis remain controversial due to limited evidence. We examined the associations of habitual soy food consumption with cardiometabolic disturbances and carotid intima-media thickness (CIMT). METHODS AND RESULTS: We included 2939 subjects (2135 women and 804 men) aged 50-75 years in this community-based cross-sectional study. Dietary data and other covariates were collected using interviewer-administered questionnaires. We determined CIMT in relation to each subject's common carotid artery, internal carotid artery, carotid bifurcation, blood lipids, glucose and urine acid, blood pressure and waist circumference. A logistic regression model was applied to estimate the odd ratios (ORs) and 95% confidence intervals (CIs), and linear regression was used to estimate the regression coefficient and 95% CIs. After adjusting for potential confounders, we found that greater consumption of soy protein (6.1 vs. 0.5 g/d) was inverse associated with the presence of elevated total cholesterol (TC), dyslipidemia, abdominal obesity and hyperuricemia in women, and with abdominal obesity in men, although no significant sex-soy interactions were observed (P: 0.145-0.985). The consumption of soy protein and isoflavones was inversely associated with the number of cardiometabolic disturbances among women, but not men. There were no significant associations of soy protein and isoflavones with CIMT thickening and other cardiometabolic disturbances. CONCLUSION: Greater soy consumption was associated with a lower presence of elevated TC, dyslipidemia, hyperuricemia and less number of cardiometabolic disturbances components in women.
Authors: Maria Ferris; Keisha Gibson; Brett Plattner; Debbie S Gipson; Peter Kotanko; Daniele Marcelli; Cristina Marelli; Michael Etter; Paola Carioni; Gero von Gersdorff; Xiaoqi Xu; Jeroen P Kooman; Qingqing Xiao; Frank M van der Sande; Albert Power; Roberto Picoits-Filho; Lucimary Sylvestre; Katherine Westreich; Len Usvyat Journal: Clin Kidney J Date: 2016-03-05
Authors: Elena Giordano; Alberto Dávalos; Maria Carmen Crespo; Joao Tomé-Carneiro; Diego Gómez-Coronado; Francesco Visioli Journal: Molecules Date: 2015-01-30 Impact factor: 4.411
Authors: Thozhukat Sathyapalan; Alison J Dawson; Alan S Rigby; Natalie J Thatcher; Eric S Kilpatrick; Stephen L Atkin Journal: Front Endocrinol (Lausanne) Date: 2018-09-11 Impact factor: 5.555