Saima Batool1, Martin O'Donnell1, Mukul Sharma1, Shofiqul Islam1, Gilles R Dagenais1, Paul Poirier1, Scott A Lear1, Andreas Wielgosz1, Koon Teo1, Grant Stotts1, Cheryl R McCreary1, Richard Frayne1, Jane DeJesus1, Sumathy Rangarajan1, Salim Yusuf1, Eric E Smith2. 1. From the Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada (S.B., R.F., E.E.S.); Department of Medicine, Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada (M.O., M.S., S.I., K.T., J.D., S.R., S.Y.); Quebec Heart and Lung Institute, Laval University, Quebec, Canada (G.R.D., P.P.); Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada (S.A.L.); Division of Cardiology, Providence Health Care, Vancouver, British Columbia, Canada (S.A.L.); The Ottawa Hospital and University of Ottawa, Ottawa, Ontario, Canada (A.W., G.S.); Department of Radiology, University of Calgary, Calgary, Alberta, Canada (C.R.M., R.F., E.E.S.); Seaman Family MR Research Centre, Alberta Health Services, Alberta, Canada (C.R.M., R.F., E.E.S.); and Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada (R.F., E.E.S.). 2. From the Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada (S.B., R.F., E.E.S.); Department of Medicine, Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada (M.O., M.S., S.I., K.T., J.D., S.R., S.Y.); Quebec Heart and Lung Institute, Laval University, Quebec, Canada (G.R.D., P.P.); Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada (S.A.L.); Division of Cardiology, Providence Health Care, Vancouver, British Columbia, Canada (S.A.L.); The Ottawa Hospital and University of Ottawa, Ottawa, Ontario, Canada (A.W., G.S.); Department of Radiology, University of Calgary, Calgary, Alberta, Canada (C.R.M., R.F., E.E.S.); Seaman Family MR Research Centre, Alberta Health Services, Alberta, Canada (C.R.M., R.F., E.E.S.); and Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada (R.F., E.E.S.). eesmith@ucalgary.ca.
Abstract
BACKGROUND AND PURPOSE: Incidental magnetic resonance diffusion-weighted imaging (DWI)-positive lesions, considered to represent small acute infarcts, have been detected in patients with cerebral small vessel diseases or cognitive impairment, but the prevalence in the community population is unknown. METHODS: DWI sequences collected in 793 participants in the Prospective Urban Rural Epidemiological (PURE) study were reviewed for DWI lesions consistent with small acute infarcts. RESULTS: No DWI-positive lesions were detected (0%, 95% confidence interval, 0-0.5). CONCLUSIONS: DWI-positive lesions are rare in an asymptomatic community population. The prevalence of DWI-positive lesions in the community seems to be lower than in patients with cerebral amyloid angiopathy, intracerebral hemorrhage, or cognitive impairment.
BACKGROUND AND PURPOSE: Incidental magnetic resonance diffusion-weighted imaging (DWI)-positive lesions, considered to represent small acute infarcts, have been detected in patients with cerebral small vessel diseases or cognitive impairment, but the prevalence in the community population is unknown. METHODS: DWI sequences collected in 793 participants in the Prospective Urban Rural Epidemiological (PURE) study were reviewed for DWI lesions consistent with small acute infarcts. RESULTS: No DWI-positive lesions were detected (0%, 95% confidence interval, 0-0.5). CONCLUSIONS: DWI-positive lesions are rare in an asymptomatic community population. The prevalence of DWI-positive lesions in the community seems to be lower than in patients with cerebral amyloid angiopathy, intracerebral hemorrhage, or cognitive impairment.
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