Keigo Komine1, Masahiro Inoue1, Kazunori Otsuka1, Koji Fukuda1, Hiroshi Nanjo2, Hiroyuki Shibata3. 1. Department of Clinical Oncology, Graduate School of Medicine, Akita University, Akita, Japan. 2. Department of Clinical Pathology, Akita University Hospital, Akita, Japan. 3. Department of Clinical Oncology, Graduate School of Medicine, Akita University, Akita, Japan hiroyuki@med.akita-u.ac.jp.
Abstract
BACKGROUND/AIM: Carcinomas of unknown primary origin (CUPs) account for 3%-5% of all malignancies. The majority of CUPs have unfavorable prognosis and are chemoresistant. Predictive biomarkers should be established to improve therapeutic outcomes. Metastatic ability of CUPs may be related to the existence of circulating tumor cells (CTCs). PATIENTS AND METHODS: Ten patients diagnosed with CUP visiting the Akita University Hospital participated in this study. CTCs were calculated by the CellSearch system. RESULTS: The present observational study indicates that CTCs were detected in 50% of CUPs, and in 80% chemotherapeutically-naïve cases. Furthermore, decrease in CTC count between the pre-treatment and post-treatment phases were observed in chemosensitive cases. CONCLUSION: Rapid assessment of the efficacy of chemotherapy by CTC count may become a useful predictive biomarker of CUPs. Copyright
BACKGROUND/AIM: Carcinomas of unknown primary origin (CUPs) account for 3%-5% of all malignancies. The majority of CUPs have unfavorable prognosis and are chemoresistant. Predictive biomarkers should be established to improve therapeutic outcomes. Metastatic ability of CUPs may be related to the existence of circulating tumor cells (CTCs). PATIENTS AND METHODS: Ten patients diagnosed with CUP visiting the Akita University Hospital participated in this study. CTCs were calculated by the CellSearch system. RESULTS: The present observational study indicates that CTCs were detected in 50% of CUPs, and in 80% chemotherapeutically-naïve cases. Furthermore, decrease in CTC count between the pre-treatment and post-treatment phases were observed in chemosensitive cases. CONCLUSION: Rapid assessment of the efficacy of chemotherapy by CTC count may become a useful predictive biomarker of CUPs. Copyright
Authors: Lukasz A Adamczyk; Hannah Williams; Aleksandra Frankow; Hayley Patricia Ellis; Harry R Haynes; Claire Perks; Jeff M P Holly; Kathreena M Kurian Journal: Front Neurol Date: 2015-08-10 Impact factor: 4.003