Maria Tengström1, Arto Mannermaa2, Veli-Matti Kosma2, Ari Hirvonen3, Vesa Kataja4. 1. Cancer Center, Kuopio University Hospital, Kuopio, Finland Institute of Clinical Medicine, Pathology, University of Eastern Finland, Kuopio, Finland Biocenter Kuopio, University of Eastern Finland, Kuopio, Finland Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland maria.tengstrom@kuh.fi. 2. Institute of Clinical Medicine, Pathology, University of Eastern Finland, Kuopio, Finland Biocenter Kuopio, University of Eastern Finland, Kuopio, Finland Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland Imaging Center, Pathology, Kuopio University Hospital, Kuopio, Finland. 3. Finnish Institute of Occupational Health, Helsinki, Finland. 4. Cancer Center, Kuopio University Hospital, Kuopio, Finland Institute of Clinical Medicine, Pathology, University of Eastern Finland, Kuopio, Finland Biocenter Kuopio, University of Eastern Finland, Kuopio, Finland Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland.
Abstract
BACKGROUND: Single nucleotide polymorphisms (SNPs) in a DNA-repair gene, X-Ray repair cross complementing group 1 (XRCC1), have been associated with the survival of patients with breast cancer. We investigated the predictive value of XRCC1 SNP (rs25487) in patients with early breast cancer. PATIENTS AND METHODS: The XRCC1 rs25487 genotypes of 411 Finnish patients with breast cancer were analyzed by a polymerase chain reaction-restriction fragment length polymorphism-based method. Survival was assessed by Kaplan-Meier method and Cox regression analysis according to the XRCC1 genotypes in specified adjuvant treatment groups. RESULTS: The rs25487 variant AA genotype was associated with worse breast cancer-specific and overall survival in 238 patients receiving postoperative radiotherapy (p=0.031 and p=0.030, respectively). The AA genotype predicted worse breast cancer-specific survival among 75 patients treated with adjuvant chemotherapy (p=0.047). CONCLUSION: The XRCC1 rs25487 genotype may predict the outcome of postoperative radiotherapy and adjuvant chemotherapy in breast cancer. Copyright
BACKGROUND: Single nucleotide polymorphisms (SNPs) in a DNA-repair gene, X-Ray repair cross complementing group 1 (XRCC1), have been associated with the survival of patients with breast cancer. We investigated the predictive value of XRCC1 SNP (rs25487) in patients with early breast cancer. PATIENTS AND METHODS: The XRCC1rs25487 genotypes of 411 Finnish patients with breast cancer were analyzed by a polymerase chain reaction-restriction fragment length polymorphism-based method. Survival was assessed by Kaplan-Meier method and Cox regression analysis according to the XRCC1 genotypes in specified adjuvant treatment groups. RESULTS: The rs25487 variant AA genotype was associated with worse breast cancer-specific and overall survival in 238 patients receiving postoperative radiotherapy (p=0.031 and p=0.030, respectively). The AA genotype predicted worse breast cancer-specific survival among 75 patients treated with adjuvant chemotherapy (p=0.047). CONCLUSION: The XRCC1rs25487 genotype may predict the outcome of postoperative radiotherapy and adjuvant chemotherapy in breast cancer. Copyright
Authors: Petra Seibold; Peter Schmezer; Sabine Behrens; Kyriaki Michailidou; Manjeet K Bolla; Qin Wang; Dieter Flesch-Janys; Heli Nevanlinna; Rainer Fagerholm; Kristiina Aittomäki; Carl Blomqvist; Sara Margolin; Arto Mannermaa; Vesa Kataja; Veli-Matti Kosma; Jaana M Hartikainen; Diether Lambrechts; Hans Wildiers; Vessela Kristensen; Grethe Grenaker Alnæs; Silje Nord; Anne-Lise Borresen-Dale; Maartje J Hooning; Antoinette Hollestelle; Agnes Jager; Caroline Seynaeve; Jingmei Li; Jianjun Liu; Keith Humphreys; Alison M Dunning; Valerie Rhenius; Mitul Shah; Maria Kabisch; Diana Torres; Hans-Ulrich Ulmer; Ute Hamann; Joellen M Schildkraut; Kristen S Purrington; Fergus J Couch; Per Hall; Paul Pharoah; Doug F Easton; Marjanka K Schmidt; Jenny Chang-Claude; Odilia Popanda Journal: BMC Cancer Date: 2015-12-16 Impact factor: 4.430