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Literature DB >> 2492231

Enclomiphene induces luteolysis in the nonpregnant guinea pig.

Abstract

The effect of two antiestrogens, enclomiphene and tamoxifen, on luteal function in the guinea pig was compared to that of estradiol, a known luteolysin. Enclomiphene caused premature luteolysis when administered during the early or mid-luteal phase of the cycle, but was not as potent as estradiol. Tamoxifen had no effect. The luteolytic effect of enclomiphene was mediated by the uterus, as has been shown for estradiol.

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Year: 1989 PMID： 2492231 DOI： 10.1007/bf01990463

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

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References

15 in total

1. Nonsteroidal antiestrogens: their biological effects and potential mechanisms of action.

Authors: V C Jordan; C J Dix; K E Naylor; G Prestwich; L Rowsby
Journal: J Toxicol Environ Health Date: 1978 Mar-May

2. Sensitisation of pituitary cells to luteinising hormone releasing hormone by clomiphene citrate in vitro.

Authors: A J Hsueh; G F Erickson; S S Yen
Journal: Nature Date: 1978-05-04 Impact factor: 49.962

3. The effect of oestrogen and progesterone on the release of prostaglandins from the uterus of the ovariectomized guinea-pig.

Authors: F R Blatchley; N L Poyser
Journal: J Reprod Fertil Date: 1974-09

10. Estrogenic and antiestrogenic effects of enclomiphene and zuclomiphene on gonadotropin secretion by ovine pituitary cells in culture.

Authors: E S Huang; W L Miller
Journal: Endocrinology Date: 1983-02 Impact factor: 4.736

Enclomiphene induces luteolysis in the nonpregnant guinea pig.

1. Nonsteroidal antiestrogens: their biological effects and potential mechanisms of action.

2. Sensitisation of pituitary cells to luteinising hormone releasing hormone by clomiphene citrate in vitro.

3. The effect of oestrogen and progesterone on the release of prostaglandins from the uterus of the ovariectomized guinea-pig.

4. The onset of first oestrus in the guinea-pig and the effects of gonadotrophins and oestradiol in the immature animal.

5. Oestrogen and progesterone and the function of the corpora lutea in the guinea-pig.

Review 6. Prostaglandin F2alpha is the uterine luteolytic hormone in the guinea pig: the evidence reviewed.

7. Evidence for the metabolic activation of non-steroidal antioestrogens: a study of structure-activity relationships.

8. Relationship of estradiol to luteal function in the cycling baboon.

9. The effect of tamoxifen on the in vitro production of prostaglandins F by the guinea pig uterine tissue.

10. Estrogenic and antiestrogenic effects of enclomiphene and zuclomiphene on gonadotropin secretion by ovine pituitary cells in culture.