Literature DB >> 24920812

Hepatitis A virus 3C protease cleaves NEMO to impair induction of beta interferon.

Dang Wang1, Liurong Fang1, Dahai Wei2, Huan Zhang1, Rui Luo1, Huanchun Chen1, Kui Li3, Shaobo Xiao4.   

Abstract

NEMO (NF-κB essential modulator) is a bridging adaptor indispensable for viral activation of interferon (IFN) antiviral response. Herein, we show that hepatitis A virus (HAV) 3C protease (3Cpro) cleaves NEMO at the Q304 residue, negating its signaling adaptor function and abrogating viral induction of IFN-β synthesis via the retinoic acid-inducible gene I/melanoma differentiation-associated protein 5 (RIG-I/MDA5) and Toll-like receptor 3 (TLR3) pathways. NEMO cleavage and IFN antagonism, however, were lost upon ablation of the catalytic activity of 3Cpro. These data describe a novel immune evasion mechanism of HAV.
Copyright © 2014, American Society for Microbiology. All Rights Reserved.

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Year:  2014        PMID： 24920812      PMCID： PMC4136334          DOI： 10.1128/JVI.00869-14

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  22 in total

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Journal:  Nature       Date:  2006-04-09       Impact factor: 49.962

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Journal:  Nat Immunol       Date:  2007-04-29       Impact factor: 25.606

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