Literature DB >> 24920241

Outstanding effects on antithrombin activity of modified TBA diastereomers containing an optically pure acyclic nucleotide analogue.

M Scuotto1, M Persico, M Bucci, V Vellecco, N Borbone, E Morelli, G Oliviero, E Novellino, G Piccialli, G Cirino, M Varra, C Fattorusso, L Mayol.   

Abstract

Herein, we report optically pure modified acyclic nucleosides as ideal probes for aptamer modification. These new monomers offer unique advantages in exploring the role played in thrombin inhibition by a single residue modification at key positions of the TBA structure.

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Year:  2014        PMID： 24920241     DOI： 10.1039/c4ob00149d

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  11 in total

Review 1.  In What Ways Do Synthetic Nucleotides and Natural Base Lesions Alter the Structural Stability of G-Quadruplex Nucleic Acids?

Authors:  Janos Sagi
Journal:  J Nucleic Acids       Date:  2017-10-18

2.  Crystal structures of thrombin in complex with chemically modified thrombin DNA aptamers reveal the origins of enhanced affinity.

Authors:  Rafal Dolot; Curtis H Lam; Malgorzata Sierant; Qiang Zhao; Feng-Wu Liu; Barbara Nawrot; Martin Egli; Xianbin Yang
Journal:  Nucleic Acids Res       Date:  2018-05-18       Impact factor: 16.971

Review 3.  Porous Silicon-Based Aptasensors: The Next Generation of Label-Free Devices for Health Monitoring.

Authors:  Monica Terracciano; Ilaria Rea; Nicola Borbone; Rosalba Moretta; Giorgia Oliviero; Gennaro Piccialli; Luca De Stefano
Journal:  Molecules       Date:  2019-06-13       Impact factor: 4.411

4.  Protein Binding of Benzofuran Derivatives: A CD Spectroscopic and In Silico Comparative Study of the Effects of 4-Nitrophenyl Functionalized Benzofurans and Benzodifurans on BSA Protein Structure.

Authors:  Pasqualina Liana Scognamiglio; Caterina Vicidomini; Francesco Fontanella; Claudio De Stefano; Rosanna Palumbo; Giovanni N Roviello
Journal:  Biomolecules       Date:  2022-02-05

5.  Site-specific replacement of the thymine methyl group by fluorine in thrombin binding aptamer significantly improves structural stability and anticoagulant activity.

Authors:  Antonella Virgilio; Luigi Petraccone; Valentina Vellecco; Mariarosaria Bucci; Michela Varra; Carlo Irace; Rita Santamaria; Antonietta Pepe; Luciano Mayol; Veronica Esposito; Aldo Galeone
Journal:  Nucleic Acids Res       Date:  2015-11-17       Impact factor: 16.971

6.  Bioactivity of 2'-deoxyinosine-incorporated aptamer AS1411.

Authors:  Xinmeng Fan; Lidan Sun; Yun Wu; Lihe Zhang; Zhenjun Yang
Journal:  Sci Rep       Date:  2016-05-19       Impact factor: 4.379

7.  Synthesis and Antioxidant Activity of 7-Thio Derivatives of 6,7-Dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione.

Authors:  Yuriy M Kononevich; Ludmila S Bobkova; Alexander S Smolski; Anatoly M Demchenko
Journal:  Sci Pharm       Date:  2014-10-29

8.  Site specific replacements of a single loop nucleoside with a dibenzyl linker may switch the activity of TBA from anticoagulant to antiproliferative.

Authors:  Maria Scuotto; Elisa Rivieccio; Alessia Varone; Daniela Corda; Mariarosaria Bucci; Valentina Vellecco; Giuseppe Cirino; Antonella Virgilio; Veronica Esposito; Aldo Galeone; Nicola Borbone; Michela Varra; Luciano Mayol
Journal:  Nucleic Acids Res       Date:  2015-08-06       Impact factor: 16.971

9.  The Bioactivity of D-/L-Isonucleoside- and 2'-Deoxyinosine-Incorporated Aptamer AS1411s Including DNA Replication/MicroRNA Expression.

Authors:  Xinmeng Fan; Lidan Sun; Kunfeng Li; Xiantao Yang; Baobin Cai; Yanfen Zhang; Yuejie Zhu; Yuan Ma; Zhu Guan; Yun Wu; Lihe Zhang; Zhenjun Yang
Journal:  Mol Ther Nucleic Acids       Date:  2017-09-30

10.  Spectroscopic Properties of Two 5'-(4-Dimethylamino)Azobenzene Conjugated G-Quadruplex Forming Oligonucleotides.

Authors:  Concetta Imperatore; Antonio Varriale; Elisa Rivieccio; Angela Pennacchio; Maria Staiano; Sabato D'Auria; Marcello Casertano; Carlo Altucci; Mohammadhassan Valadan; Manjot Singh; Marialuisa Menna; Michela Varra
Journal:  Int J Mol Sci       Date:  2020-09-26       Impact factor: 5.923
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