Kara M Hawkins1, Lauren E Sergio1. 1. School of Kinesiology and Health Science, Centre for Vision Research, Neuroscience Graduate Diploma Program, York University, Toronto, ON, Canada.
Abstract
BACKGROUND AND OBJECTIVE: Recent evidence suggests that visuomotor behaviors may be disrupted in the very early stages of Alzheimer's disease (AD). Here we propose that using kinematic measures under conditions that place demands on visual-spatial and cognitive-motor processing may provide an effective behavioral means to detect subtle changes associated with AD risk. METHODS: To this end, we have tested 22 young adults (mean age = 26.4 ± 4.1) and 22 older adults (mean age = 64.3 ± 10.1) at low AD, and 22 older adults (mean age = 67.7 ± 11.3) at high AD risk (i.e., strong family history or diagnosis of mild cognitive impairment). Kinematic measures were acquired on four visuomotor transformation tasks (standard, feedback reversal, plane dissociated, and plane dissociated + feedback reversal) using a dual-touchscreen tablet. RESULTS: Comparing participants at increased AD risk with both young and old healthy control groups revealed significant performance disruptions in at-risk individuals as task demands increased. Furthermore, we were able to discriminate between individuals at high and low AD risk with a classification accuracy of 86.4% (sensitivity: 81.8%, specificity: 90.9%). CONCLUSION: We suggest that the impairments observed in individuals at increased AD risk may reflect inherent brain alteration and/or early neuropathology disrupting the reciprocal communication between hippocampal, parietal, and frontal brain regions required to successfully prepare and update complex reaching movements. Such impairment has the potential to affect activities of daily living, and may serve as a sensitive measure of functional ability in at-risk adults.
BACKGROUND AND OBJECTIVE: Recent evidence suggests that visuomotor behaviors may be disrupted in the very early stages of Alzheimer's disease (AD). Here we propose that using kinematic measures under conditions that place demands on visual-spatial and cognitive-motor processing may provide an effective behavioral means to detect subtle changes associated with AD risk. METHODS: To this end, we have tested 22 young adults (mean age = 26.4 ± 4.1) and 22 older adults (mean age = 64.3 ± 10.1) at low AD, and 22 older adults (mean age = 67.7 ± 11.3) at high AD risk (i.e., strong family history or diagnosis of mild cognitive impairment). Kinematic measures were acquired on four visuomotor transformation tasks (standard, feedback reversal, plane dissociated, and plane dissociated + feedback reversal) using a dual-touchscreen tablet. RESULTS: Comparing participants at increased AD risk with both young and old healthy control groups revealed significant performance disruptions in at-risk individuals as task demands increased. Furthermore, we were able to discriminate between individuals at high and low AD risk with a classification accuracy of 86.4% (sensitivity: 81.8%, specificity: 90.9%). CONCLUSION: We suggest that the impairments observed in individuals at increased AD risk may reflect inherent brain alteration and/or early neuropathology disrupting the reciprocal communication between hippocampal, parietal, and frontal brain regions required to successfully prepare and update complex reaching movements. Such impairment has the potential to affect activities of daily living, and may serve as a sensitive measure of functional ability in at-risk adults.
Authors: Alexandra G Mitchell; Stephanie Rossit; Suvankar Pal; Michael Hornberger; Annie Warman; Elise Kenning; Laura Williamson; Rebecca Shapland; Robert D McIntosh Journal: Cortex Date: 2022-01-31 Impact factor: 4.027
Authors: Leif E R Simmatis; Spencer Early; Kimberly D Moore; Simone Appaqaq; Stephen H Scott Journal: J Neuroeng Rehabil Date: 2020-07-02 Impact factor: 4.262
Authors: Michael D Wood; Jasmine Khan; Kevin F H Lee; David M Maslove; John Muscedere; Miranda Hunt; Stephen H Scott; Andrew Day; Jill A Jacobson; Ian Ball; Marat Slessarev; Niamh O'Regan; Shane W English; Victoria McCredie; Michaël Chasse; Donald Griesdale; J Gordon Boyd Journal: BMJ Open Date: 2019-06-25 Impact factor: 2.692