Literature DB >> 24918837

Contemporary treatment options for relapsing-remitting multiple sclerosis.

S Salhofer-Polanyi1, F Leutmezer2.   

Abstract

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system, encompassing both neuroinflammatory as well as prominent neurodegenerative aspects. A significant proportion of MS patients will develop neurological disability over time and up until recently licensed drugs could not satisfactorily halt this process. However, in the last years MS treatment has raised a stage of rapid progress. Several new drugs with significantly improved efficacy have entered the therapeutic field and several others are currently undergoing phase III clinical trials. In this review, we will summarize efficacy data as well as safety and tolerability issues of currently licensed drugs for relapsing-remitting MS and will give a short update on new drugs currently undergoing late-stage clinical trials. Copyright 2014 Prous Science, S.A.U. or its licensors. All rights reserved.

Entities:  

Keywords:  Alemtuzumab; Dimethyl fumarate; Fingolimod; Multiple sclerosis; Relapsing-remitting multiple sclerosis; Teriflunomide

Mesh:

Substances:

Year:  2014        PMID: 24918837     DOI: 10.1358/dot.2014.50.5.2132741

Source DB:  PubMed          Journal:  Drugs Today (Barc)        ISSN: 1699-3993            Impact factor:   2.245


  3 in total

1.  Adrenocorticotropic hormone versus methylprednisolone added to interferon β in patients with multiple sclerosis experiencing breakthrough disease: a randomized, rater-blinded trial.

Authors:  Regina Berkovich; Rohit Bakshi; Lilyana Amezcua; Robert C Axtell; Steven Y Cen; Shahamat Tauhid; Mohit Neema; Lawrence Steinman
Journal:  Ther Adv Neurol Disord       Date:  2016-10-19       Impact factor: 6.570

Review 2.  Consensus opinion of US neurologists on practice patterns in RIS, CIS, and RRMS: Evolution of treatment practices.

Authors:  Carlo Tornatore; J Theodore Phillips; Omar Khan; Aaron E Miller; Mark Hughes
Journal:  Neurol Clin Pract       Date:  2016-08

3.  Fludarabine add-on therapy in interferon-beta-treated patients with multiple sclerosis experiencing breakthrough disease.

Authors:  Steven J Greenberg; Robert Zivadinov; Peterkin Lee-Kwen; Jitendra Sharma; Margaret Planter; Margaret Umhauer; Norman Glenister; Rohit Bakshi
Journal:  Ther Adv Neurol Disord       Date:  2016-01-21       Impact factor: 6.570

  3 in total

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