OBJECTIVES: To determine the prevalence of potentially inappropriate medications (PIMs) and related factors through a comparative analysis of the Screening Tool of Older Person's Potentially Inappropriate Prescriptions (STOPP), the 2003 Beers criteria, and the 2012 AGS update of the Beers criteria. DESIGN: Cross-sectional. SETTING: Primary care. PARTICIPANTS: Community-dwelling persons aged 65 and older who live on the island of Lanzarote, Spain (N = 407). MEASUREMENTS: Sociodemographic characteristics; independence in activities of daily living; cognitive function; Geriatric Depression Scale; clinical diagnoses; and complete data on indication, dosage, and length of drug treatments. One thousand eight hundred seventh-two prescriptions were examined, and the rate of PIMs was assessed with the three criteria. The primary endpoint was the percentage of participants receiving at least one PIM. Multivariate logistic regression was used to examine the factors related to PIMs. RESULTS: Potentially inappropriate medications were present in 24.3%, 35.4%, and 44% of participants, according to the 2003 Beers criteria, STOPP, and 2012 Beers criteria, respectively. The profile of PIMs was also different (the most frequent being benzodiazepines in both Beers criteria lists and aspirin in the STOPP). The number of drugs was associated with risk of prescribing PIMs in all three models, as was the presence of a psychological disorder in the 2003 Beers criteria (odds ratio (OR) = 2.07, 95% confidence interval (CI) = 1.26-3.40) and the 2012 Beers criteria (OR = 2.91, 95% CI = 1.83-4.66). The kappa for degree of agreement between STOPP and the 2012 Beers criteria was 0.35 (95% CI = 0.25-0.44). CONCLUSION: The 2012 Beers criteria detected the highest number of PIMs, and given the scant overlapping with the STOPP criteria, the use of both tools may be seen as complementary.
OBJECTIVES: To determine the prevalence of potentially inappropriate medications (PIMs) and related factors through a comparative analysis of the Screening Tool of Older Person's Potentially Inappropriate Prescriptions (STOPP), the 2003 Beers criteria, and the 2012 AGS update of the Beers criteria. DESIGN: Cross-sectional. SETTING: Primary care. PARTICIPANTS: Community-dwelling persons aged 65 and older who live on the island of Lanzarote, Spain (N = 407). MEASUREMENTS: Sociodemographic characteristics; independence in activities of daily living; cognitive function; Geriatric Depression Scale; clinical diagnoses; and complete data on indication, dosage, and length of drug treatments. One thousand eight hundred seventh-two prescriptions were examined, and the rate of PIMs was assessed with the three criteria. The primary endpoint was the percentage of participants receiving at least one PIM. Multivariate logistic regression was used to examine the factors related to PIMs. RESULTS: Potentially inappropriate medications were present in 24.3%, 35.4%, and 44% of participants, according to the 2003 Beers criteria, STOPP, and 2012 Beers criteria, respectively. The profile of PIMs was also different (the most frequent being benzodiazepines in both Beers criteria lists and aspirin in the STOPP). The number of drugs was associated with risk of prescribing PIMs in all three models, as was the presence of a psychological disorder in the 2003 Beers criteria (odds ratio (OR) = 2.07, 95% confidence interval (CI) = 1.26-3.40) and the 2012 Beers criteria (OR = 2.91, 95% CI = 1.83-4.66). The kappa for degree of agreement between STOPP and the 2012 Beers criteria was 0.35 (95% CI = 0.25-0.44). CONCLUSION: The 2012 Beers criteria detected the highest number of PIMs, and given the scant overlapping with the STOPP criteria, the use of both tools may be seen as complementary.
Authors: Magali Gonzalez-Colaço Harmand; Ana María Aldea-Perona; Carlos Boada-Fernández Del Campo; Almudena Areosa-Sastre; Consuelo Rodríguez-Jiménez; Marcelino García Sánchez-Colomer; Eduardo Fernández Quintana; Mercedes Plasencia-Nuñez; Paula Masiero-Aparicio; Candelaria Grillo-Grillo; Andrés Orellana-Mobilli; Mar García Sáiz; Carmen Duarte Diéguez; Mercedes Hornillos Calvo; Juan Antonio Avellana Zaragoza; Nicolás Martínez Velilla; Domingo de Guzmán Pérez Hernández; Mario Ruiz González; Encarnación Blanco Reina; Carmen Asensio Ostos; Ana Peiró; Lourdes Cabrera García; Fuensanta Hortigüela Moro; Herlinda Pérez Alayón; Iriana Espárrago García; Javier Santana Quilez; Javier Alonso Ramírez; Carlos Fernández Oropesa; Mª José López Varona; Mª Teresa Acín Gerico; Emilio Sanz Alvarez; María Ángeles Martín de la Sierra; María José Peñalver; Teresa Falomir Gómez; Jesús Ruiz Salazar; Gabriela Elizondo Rivas; Edmundo Rey Rodríguez Journal: Eur J Clin Pharmacol Date: 2019-05-08 Impact factor: 2.953