Literature DB >> 24916696

Twisting and ironing: doxorubicin cardiotoxicity by mitochondrial DNA damage.

Karin C Nitiss1, John L Nitiss2.   

Abstract

Anthracyclines are active clinical agents that have multiple mechanisms of cytotoxicity. Cardiotoxicity by anthracyclines limits the therapeutic potential of these agents, but mechanisms leading to cardiotoxicity remain controversial. Transgenic mice that lack mitochondrial topoisomerase I are hypersensitive to doxorubicin cardiotoxicity, providing support for cardiotoxicity arising from damage of mitochondrial DNA. ©2014 American Association for Cancer Research.

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Year:  2014        PMID： 24916696      PMCID： PMC4204112          DOI： 10.1158/1078-0432.CCR-14-0821

Source DB:  PubMed          Journal:  Clin Cancer Res        ISSN： 1078-0432            Impact factor:   12.531


  12 in total

1.  Human mitochondrial topoisomerase I.

Authors:  H Zhang; J M Barceló; B Lee; G Kohlhagen; D B Zimonjic; N C Popescu; Y Pommier
Journal:  Proc Natl Acad Sci U S A       Date:  2001-08-28       Impact factor: 11.205

2.  Mitochondrial topoisomerase I (top1mt) is a novel limiting factor of doxorubicin cardiotoxicity.

Authors:  Salim Khiati; Ilaria Dalla Rosa; Carole Sourbier; Xuefei Ma; V Ashutosh Rao; Leonard M Neckers; Hongliang Zhang; Yves Pommier
Journal:  Clin Cancer Res       Date:  2014-04-08       Impact factor: 12.531

Review 3.  Dexrazoxane for the prevention of cardiac toxicity and treatment of extravasation injury from the anthracycline antibiotics.

Authors:  James H Doroshow
Journal:  Curr Pharm Biotechnol       Date:  2012-08       Impact factor: 2.837

4.  Identification of the molecular basis of doxorubicin-induced cardiotoxicity.

Authors:  Sui Zhang; Xiaobing Liu; Tasneem Bawa-Khalfe; Long-Sheng Lu; Yi Lisa Lyu; Leroy F Liu; Edward T H Yeh
Journal:  Nat Med       Date:  2012-10-28       Impact factor: 53.440

Review 5.  Adriamycin-induced interference with cardiac mitochondrial calcium homeostasis.

Authors:  Kendall B Wallace
Journal:  Cardiovasc Toxicol       Date:  2007       Impact factor: 3.231

Review 6.  Oxidative stress, redox signaling, and metal chelation in anthracycline cardiotoxicity and pharmacological cardioprotection.

Authors:  Martin Stěrba; Olga Popelová; Anna Vávrová; Eduard Jirkovský; Petra Kovaříková; Vladimír Geršl; Tomáš Simůnek
Journal:  Antioxid Redox Signal       Date:  2012-10-12       Impact factor: 8.401

Review 7.  The role of iron in anthracycline cardiotoxicity.

Authors:  Elena Gammella; Federica Maccarinelli; Paolo Buratti; Stefania Recalcati; Gaetano Cairo
Journal:  Front Pharmacol       Date:  2014-02-26       Impact factor: 5.810

8.  Mitochondrial topoisomerase I is critical for mitochondrial integrity and cellular energy metabolism.

Authors:  Céline Douarre; Carole Sourbier; Ilaria Dalla Rosa; Benu Brata Das; Christophe E Redon; Hongliang Zhang; Len Neckers; Yves Pommier
Journal:  PLoS One       Date:  2012-07-20       Impact factor: 3.240

9.  Negative regulation of mitochondrial transcription by mitochondrial topoisomerase I.

Authors:  Stefan Sobek; Ilaria Dalla Rosa; Yves Pommier; Beatrice Bornholz; Faiza Kalfalah; Hongliang Zhang; Rudolf J Wiesner; Jürgen-Christoph von Kleist-Retzow; Frank Hillebrand; Heiner Schaal; Christian Mielke; Morten O Christensen; Fritz Boege
Journal:  Nucleic Acids Res       Date:  2013-08-27       Impact factor: 16.971

10.  Mice lacking mitochondrial ferritin are more sensitive to doxorubicin-mediated cardiotoxicity.

Authors:  Federica Maccarinelli; Elena Gammella; Michela Asperti; Maria Regoni; Giorgio Biasiotto; Emilia Turco; Fiorella Altruda; Silvia Lonardi; Laura Cornaghi; Elena Donetti; Stefania Recalcati; Maura Poli; Dario Finazzi; Paolo Arosio; Gaetano Cairo
Journal:  J Mol Med (Berl)       Date:  2014-04-13       Impact factor: 4.599
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  14 in total

Review 1.  Curing Cancer, Saving the Heart: A Challenge That Cardioncology Should Not Miss.

Authors:  Daniela Cardinale; Gina Biasillo; Carlo Maria Cipolla
Journal:  Curr Cardiol Rep       Date:  2016-06       Impact factor: 2.931

2.  A porous polyaniline nanotube sorbent for solid-phase extraction of the fluorescent reaction product of reactive oxygen species in cells, and its determination by HPLC.

Authors:  Panhong Niu; Feifei Li; Xiaojing Liang; Xiudan Hou; Xiaofeng Lu; Xusheng Wang; Qiang Li; Yong Guo
Journal:  Mikrochim Acta       Date:  2018-09-19       Impact factor: 5.833

3.  VEGF-B gene therapy inhibits doxorubicin-induced cardiotoxicity by endothelial protection.

Authors:  Markus Räsänen; Joni Degerman; Tuuli A Nissinen; Ilkka Miinalainen; Risto Kerkelä; Antti Siltanen; Janne T Backman; Eero Mervaala; Juha J Hulmi; Riikka Kivelä; Kari Alitalo
Journal:  Proc Natl Acad Sci U S A       Date:  2016-10-31       Impact factor: 11.205

Review 4.  A "Double-Edged" Scaffold: Antitumor Power within the Antibacterial Quinolone.

Authors:  Gregory S Bisacchi; Michael R Hale
Journal:  Curr Med Chem       Date:  2016       Impact factor: 4.530

5.  Pharmacokinetic-pharmacodynamic modelling of acute N-terminal pro B-type natriuretic peptide after doxorubicin infusion in breast cancer.

Authors:  Shuang Liang; Richard C Brundage; Pamala A Jacobson; Anne Blaes; Mark N Kirstein
Journal:  Br J Clin Pharmacol       Date:  2016-06-03       Impact factor: 4.335

6.  Astragalus polysaccharide suppresses doxorubicin-induced cardiotoxicity by regulating the PI3k/Akt and p38MAPK pathways.

Authors:  Yuan Cao; Yang Ruan; Tao Shen; Xiuqing Huang; Meng Li; Weiwei Yu; Yuping Zhu; Yong Man; Shu Wang; Jian Li
Journal:  Oxid Med Cell Longev       Date:  2014-10-16       Impact factor: 6.543

Review 7.  Protective Effects of ω-3 PUFA in Anthracycline-Induced Cardiotoxicity: A Critical Review.

Authors:  Simona Serini; Renata Ottes Vasconcelos; Renata Nascimento Gomes; Gabriella Calviello
Journal:  Int J Mol Sci       Date:  2017-12-12       Impact factor: 5.923

8.  Astragalus polysaccharide restores autophagic flux and improves cardiomyocyte function in doxorubicin-induced cardiotoxicity.

Authors:  Yuan Cao; Tao Shen; Xiuqing Huang; Yajun Lin; Beidong Chen; Jing Pang; Guoping Li; Que Wang; Sylvia Zohrabian; Chao Duan; Yang Ruan; Yong Man; Shu Wang; Jian Li
Journal:  Oncotarget       Date:  2017-01-17

9.  MicroRNA-140-5p aggravates doxorubicin-induced cardiotoxicity by promoting myocardial oxidative stress via targeting Nrf2 and Sirt2.

Authors:  Lisha Zhao; Yan Qi; Lina Xu; Xufeng Tao; Xu Han; Lianhong Yin; Jinyong Peng
Journal:  Redox Biol       Date:  2017-12-29       Impact factor: 11.799

Review 10.  High Density Lipoprotein and Its Precursor Protein Apolipoprotein A1 as Potential Therapeutics to Prevent Anthracycline Associated Cardiotoxicity.

Authors:  George E G Kluck; Kristina K Durham; Jeong-Ah Yoo; Bernardo L Trigatti
Journal:  Front Cardiovasc Med       Date:  2020-04-28
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