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Literature DB >> 24914986

Structure of the LCMV nucleoprotein provides a template for understanding arenavirus replication and immunosuppression.

Brandyn R West¹, Kathryn M Hastie¹, Erica Ollmann Saphire¹.

Abstract

The X-ray crystal structure of the Lymphocytic choriomeningitis virus nucleoprotein C-terminal immunosuppressive domain (LCMV NPΔ340) was determined to 2.0 Å resolution. The structure indicates that LCMV NPΔ340, like the other structurally characterized arenaviral nucleoproteins, adopts the fold of an exonuclease. This structure provides a crucial three-dimensional template for functional exploration of the replication and immunosuppression of this prototypic arenavirus.

Entities: Species

Keywords: Lymphocytic choriomeningitis virus; nucleoprotein

Mesh：

Substances：
Viral Proteins

Year: 2014 PMID： 24914986 PMCID： PMC4051510 DOI： 10.1107/S1399004714007883

Source DB: PubMed Journal: Acta Crystallogr D Biol Crystallogr ISSN： 0907-4449

31 in total

Review 1. Rare, unusual, and less common virus infections after organ transplantation.

Authors: Raymund R Razonable
Journal: Curr Opin Organ Transplant Date: 2011-12 Impact factor: 2.640

2. Inhibition of the type I interferon response by the nucleoprotein of the prototypic arenavirus lymphocytic choriomeningitis virus.

Authors: Luis Martínez-Sobrido; Elina I Zúñiga; Debralee Rosario; Adolfo García-Sastre; Juan Carlos de la Torre
Journal: J Virol Date: 2006-09 Impact factor: 5.103

3. Arenavirus nucleoprotein targets interferon regulatory factor-activating kinase IKKε.

Authors: Christelle Pythoud; W W Shanaka I Rodrigo; Giulia Pasqual; Sylvia Rothenberger; Luis Martínez-Sobrido; Juan Carlos de la Torre; Stefan Kunz
Journal: J Virol Date: 2012-04-24 Impact factor: 5.103

4. Structure of the Lassa virus nucleoprotein reveals a dsRNA-specific 3' to 5' exonuclease activity essential for immune suppression.

Authors: Kathryn M Hastie; Christopher R Kimberlin; Michelle A Zandonatti; Ian J MacRae; Erica Ollmann Saphire
Journal: Proc Natl Acad Sci U S A Date: 2011-01-24 Impact factor: 11.205

5. Arenavirus nucleoproteins prevent activation of nuclear factor kappa B.

Authors: W W Shanaka I Rodrigo; Emilio Ortiz-Riaño; Christelle Pythoud; Stefan Kunz; Juan C de la Torre; Luis Martínez-Sobrido
Journal: J Virol Date: 2012-05-23 Impact factor: 5.103

6. Lassa fever, a new virus disease of man from West Africa. I. Clinical description and pathological findings.

Authors: J D Frame; J M Baldwin; D J Gocke; J M Troup
Journal: Am J Trop Med Hyg Date: 1970-07 Impact factor: 2.345

Review 7. The role of dendritic cells in viral persistence.

Authors: Cherie T Ng; Brian M Sullivan; Michael B A Oldstone
Journal: Curr Opin Virol Date: 2011-09 Impact factor: 7.090

8. Role of the virus nucleoprotein in the regulation of lymphocytic choriomeningitis virus transcription and RNA replication.

Authors: Daniel D Pinschewer; Mar Perez; Juan Carlos de la Torre
Journal: J Virol Date: 2003-03 Impact factor: 5.103

Review 9. Lymphocytic choriomeningitis virus: an underrecognized cause of neurologic disease in the fetus, child, and adult.

Authors: Daniel J Bonthius
Journal: Semin Pediatr Neurol Date: 2012-09 Impact factor: 1.636

Review 10. Role of lymphocytic choriomeningitis virus (LCMV) in understanding viral immunology: past, present and future.

Authors: Xin Zhou; Srividya Ramachandran; Margaret Mann; Daniel L Popkin
Journal: Viruses Date: 2012-10-29 Impact factor: 5.048

9 in total

1. Lassa Virus, but Not Highly Pathogenic New World Arenaviruses, Restricts Immunostimulatory Double-Stranded RNA Accumulation during Infection.

Authors: Elizabeth J Mateer; Junki Maruyama; Galen E Card; Slobodan Paessler; Cheng Huang
Journal: J Virol Date: 2020-04-16 Impact factor: 5.103

9. The Antiviral Effect of the Chemical Compounds Targeting DED/EDh Motifs of the Viral Proteins on Lymphocytic Choriomeningitis Virus and SARS-CoV-2.

Authors: Mya Myat Ngwe Tun; Kouichi Morita; Takeshi Ishikawa; Shuzo Urata
Journal: Viruses Date: 2021-06-24 Impact factor: 5.048

9 in total

Structure of the LCMV nucleoprotein provides a template for understanding arenavirus replication and immunosuppression.

Review 1. Rare, unusual, and less common virus infections after organ transplantation.

2. Inhibition of the type I interferon response by the nucleoprotein of the prototypic arenavirus lymphocytic choriomeningitis virus.

3. Arenavirus nucleoprotein targets interferon regulatory factor-activating kinase IKKε.

4. Structure of the Lassa virus nucleoprotein reveals a dsRNA-specific 3' to 5' exonuclease activity essential for immune suppression.

5. Arenavirus nucleoproteins prevent activation of nuclear factor kappa B.

6. Lassa fever, a new virus disease of man from West Africa. I. Clinical description and pathological findings.

Review 7. The role of dendritic cells in viral persistence.

8. Role of the virus nucleoprotein in the regulation of lymphocytic choriomeningitis virus transcription and RNA replication.

Review 9. Lymphocytic choriomeningitis virus: an underrecognized cause of neurologic disease in the fetus, child, and adult.

Review 10. Role of lymphocytic choriomeningitis virus (LCMV) in understanding viral immunology: past, present and future.

1. Lassa Virus, but Not Highly Pathogenic New World Arenaviruses, Restricts Immunostimulatory Double-Stranded RNA Accumulation during Infection.

Review 2. Hemorrhagic Fever-Causing Arenaviruses: Lethal Pathogens and Potent Immune Suppressors.

Review 3. Transcription and replication mechanisms of Bunyaviridae and Arenaviridae L proteins.

Review 4. Distinct Molecular Mechanisms of Host Immune Response Modulation by Arenavirus NP and Z Proteins.

Review 5. Brothers in Arms: Structure, Assembly and Function of Arenaviridae Nucleoprotein.

6. Isolation of Reconstructed Functional Ribonucleoprotein Complexes of Machupo Virus.

7. Visualization of Double-Stranded RNA Colocalizing With Pattern Recognition Receptors in Arenavirus Infected Cells.

8. Viral nucleoprotein antibodies activate TRIM21 and induce T cell immunity.

9. The Antiviral Effect of the Chemical Compounds Targeting DED/EDh Motifs of the Viral Proteins on Lymphocytic Choriomeningitis Virus and SARS-CoV-2.