Literature DB >> 24914804

A small-molecule targeting the microRNA binding domain of argonaute 2 improves the retinoic acid differentiation response of the acute promyelocytic leukemia cell line NB4.

Silvia Masciarelli1, Roberto Quaranta, Ilaria Iosue, Gianni Colotti, Fabrizio Padula, Greta Varchi, Francesco Fazi, Alberto Del Rio.   

Abstract

Argonaute proteins are pivotal regulators of gene expression mediating miRNAs function. Modulating their activity would be extremely useful to elucidate the processes governing small-RNAs-guided gene silencing. We report the identification of a chemical compound able to compete with Argonaute 2 miRNAs binding, and we demonstrate that this functional inhibition determines effects similar to Argonaute 2 shRNA-mediated down-regulation, favoring granulocytic differentiation of the acute promyelocytic leukemia cell line NB4 in response to retinoic acid.

Entities:  

Mesh：

Substances：

Year:  2014        PMID： 24914804     DOI： 10.1021/cb500286b

Source DB:  PubMed          Journal:  ACS Chem Biol        ISSN： 1554-8929            Impact factor:   5.100


  11 in total

1.  Fyn and argonaute 2 participate in maternal-mRNA degradation during mouse oocyte maturation.

Authors:  Natalie Gindi; Hadas Grossman; Hadas Bar-Joseph; Irit Miller; Luba Nemerovsky; Ron Hadas; Nava Nevo; Dalia Galiani; Nava Dekel; Ruth Shalgi
Journal:  Cell Cycle       Date:  2022-02-01       Impact factor: 5.173

Review 2.  Computer-aided Molecular Design of Compounds Targeting Histone Modifying Enzymes.

Authors:  Federico Andreoli; Alberto Del Rio
Journal:  Comput Struct Biotechnol J       Date:  2015-05-07       Impact factor: 7.271

3.  Tetrandrine induces autophagy and differentiation by activating ROS and Notch1 signaling in leukemia cells.

Authors:  Ting Liu; Qiuxu Men; Guixian Wu; Chunrong Yu; Zan Huang; Xin Liu; Wenhua Li
Journal:  Oncotarget       Date:  2015-04-10

Review 4.  From the Argonauts Mythological Sailors to the Argonautes RNA-Silencing Navigators: Their Emerging Roles in Human-Cell Pathologies.

Authors:  Vasiliki I Pantazopoulou; Stella Georgiou; Panos Kakoulidis; Stavroula N Giannakopoulou; Sofia Tseleni; Dimitrios J Stravopodis; Ema Anastasiadou
Journal:  Int J Mol Sci       Date:  2020-06-03       Impact factor: 5.923

Review 5.  RNAs and RNA-Binding Proteins in Immuno-Metabolic Homeostasis and Diseases.

Authors:  Esam S B Salem; Andrew D Vonberg; Vishnupriya J Borra; Rupinder K Gill; Takahisa Nakamura
Journal:  Front Cardiovasc Med       Date:  2019-08-20

6.  No evidence for Ago2 translocation from the host erythrocyte into the Plasmodium parasite.

Authors:  Franziska Hentzschel; Klara Obrova; Matthias Marti
Journal:  Wellcome Open Res       Date:  2020-11-20

7.  Self-assembling ferritin-dendrimer nanoparticles for targeted delivery of nucleic acids to myeloid leukemia cells.

Authors:  Federica Palombarini; Silvia Masciarelli; Alessio Incocciati; Francesca Liccardo; Elisa Di Fabio; Antonia Iazzetti; Giancarlo Fabrizi; Francesco Fazi; Alberto Macone; Alessandra Bonamore; Alberto Boffi
Journal:  J Nanobiotechnology       Date:  2021-06-09       Impact factor: 10.435

8.  High-efficiency unassisted transfection of platelets with naked double-stranded miRNAs modulates signal-activated translation and platelet function.

Authors:  Sophia Lazar; Jeremy G T Wurtzel; Xi Chen; Peisong Ma; Lawrence E Goldfinger
Journal:  Platelets       Date:  2020-08-25       Impact factor: 4.236

9.  Structure-guided screening strategy combining surface plasmon resonance with nuclear magnetic resonance for identification of small-molecule Argonaute 2 inhibitors.

Authors:  Toshimasa Harumoto; Atsuko Sato; Yuki Takayama; Hikaru Miyagi; Jun-Ichi Saito; Fumikazu Shinohara
Journal:  PLoS One       Date:  2020-07-31       Impact factor: 3.240

Review 10.  RNA packaging into extracellular vesicles: An orchestra of RNA-binding proteins?

Authors:  Fabrizio Fabbiano; Jessica Corsi; Elena Gurrieri; Caterina Trevisan; Michela Notarangelo; Vito G D'Agostino
Journal:  J Extracell Vesicles       Date:  2020-12-28
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.