BACKGROUND: To evaluate the deposition efficiency of spray droplets in a nasal cavity produced from a spray device, it is important to determine droplet size distribution, velocity, and its dispersion during atomization. Due to the limiting geometric dimensions of the nasal cavity airway, the spray plume cannot develop to its full size inside the nasal vestibule to penetrate the nasal valve region for effective drug deposition. METHODS: Particle/droplet image analysis was used to determine local mean droplet sizes at eight regions within the spray plume under different actuation pressures that represent typical hand operation from pediatric to adult patients. RESULTS: The results showed that higher actuation pressure produces smaller droplets in the atomization. Stronger actuation pressure typical of adult users produces a longer period of the fully atomized spray stage, despite a shorter overall spray duration. This produces finer droplets when compared with the data obtained by weaker actuation pressure, typical of pediatric users. CONCLUSION: The experimental technique presented is able to capture a more complete representation of the droplet size distribution and the atomization process during an actuation. The measured droplet size distribution produced can be related to the empirically defined deposition efficiency curve of the nasal cavity, allowing a prediction of the likely deposition.
BACKGROUND: To evaluate the deposition efficiency of spray droplets in a nasal cavity produced from a spray device, it is important to determine droplet size distribution, velocity, and its dispersion during atomization. Due to the limiting geometric dimensions of the nasal cavity airway, the spray plume cannot develop to its full size inside the nasal vestibule to penetrate the nasal valve region for effective drug deposition. METHODS: Particle/droplet image analysis was used to determine local mean droplet sizes at eight regions within the spray plume under different actuation pressures that represent typical hand operation from pediatric to adult patients. RESULTS: The results showed that higher actuation pressure produces smaller droplets in the atomization. Stronger actuation pressure typical of adult users produces a longer period of the fully atomized spray stage, despite a shorter overall spray duration. This produces finer droplets when compared with the data obtained by weaker actuation pressure, typical of pediatric users. CONCLUSION: The experimental technique presented is able to capture a more complete representation of the droplet size distribution and the atomization process during an actuation. The measured droplet size distribution produced can be related to the empirically defined deposition efficiency curve of the nasal cavity, allowing a prediction of the likely deposition.
Authors: Saikat Basu; Landon T Holbrook; Kathryn Kudlaty; Olulade Fasanmade; Jihong Wu; Alyssa Burke; Benjamin W Langworthy; Zainab Farzal; Mohammed Mamdani; William D Bennett; Jason P Fine; Brent A Senior; Adam M Zanation; Charles S Ebert; Adam J Kimple; Brian D Thorp; Dennis O Frank-Ito; Guilherme J M Garcia; Julia S Kimbell Journal: Sci Rep Date: 2020-06-29 Impact factor: 4.379
Authors: Jasmina M Luczo; Tatiana Bousse; Scott K Johnson; Cheryl A Jones; Nicholas Pearce; Carlie A Neiswanger; Min-Xuan Wang; Erin A Miller; Nikolai Petrovsky; David E Wentworth; Victor Bronshtein; Mark Papania; Stephen M Tompkins Journal: NPJ Vaccines Date: 2021-04-21 Impact factor: 7.344