| Literature DB >> 24914508 |
Jérémy Ruiz1, Sonia Mallet-Ladeira, Marjorie Maynadier, Henri Vial, Christiane André-Barrès.
Abstract
Diastereoselective autoxidation allowed preparation of new tricyclic endoperoxides. These compounds and their methylated analogs were evaluated against the in vitro growth of Plasmodium falciparum, the malaria-causing parasite, showing moderate activities. However, hybrid molecules composed of the tricyclic peroxide moiety and 7-chloro-4-aminoquinoline were synthesized and displayed a marked increase in antiplasmodial activity.Entities:
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Year: 2014 PMID： 24914508 DOI： 10.1039/c4ob00787e
Source DB: PubMed Journal: Org Biomol Chem ISSN： 1477-0520 Impact factor: 3.876